scholarly journals Transcriptional Program of Ciliated Epithelial Cells Reveals New Cilium and Centrosome Components and Links to Human Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52166 ◽  
Author(s):  
Ramona A. Hoh ◽  
Timothy R. Stowe ◽  
Erin Turk ◽  
Tim Stearns
Keyword(s):  
Epithelial Cells ◽  
Human Disease ◽  
Transcriptional Program ◽  
Ciliated Epithelial Cells

Shedding of Infected Ciliated Epithelial Cells in Rhinovirus Colds

1982 ◽  
Vol 145 (6) ◽  
pp. 849-853 ◽  
Author(s):  
R. B. Turner ◽  
J. O. Hendley ◽  
J. M. Gwaltney
Keyword(s):  
Epithelial Cells ◽  
Ciliated Epithelial Cells

scholarly journals Development of microtubule capping structures in ciliated epithelial cells

1987 ◽  
Vol 87 (1) ◽  
pp. 85-94
Author(s):  
R.W. Portman ◽  
E.L. LeCluyse ◽  
W.L. Dentler
Keyword(s):  
Epithelial Cells ◽  
Microtubule Assembly ◽  
Ciliated Epithelial Cells

Although capping structures are present at the tips of microtubules in both growing cilia and mature cilia, previous work has not determined the time of cap formation. The results reported here reveal that the large caps of mature palate cilia appear in cilia with lengths as short as 1.75 micron. In the growing palate cilium, a disk-shaped plate is formed at the tip during the first micron of growth. As the cilium elongates to 1.5-2.0 microns, a small plate forms underneath the disk-shaped plate that gives an asymmetrical appearance to the whole cap structure. The structure of the cap is complete in cilia longer than 2.0 microns. The hair-like structures that form the extraciliary crown appear on the membrane at the ciliary tip at the same time as the mature cap is forming. The formation of a cap structure is discussed in relation to microtubule assembly during ciliogenesis.

scholarly journals HNF-3/Forkhead Homologue-4 (HFH-4) Is Expressed in Ciliated Epithelial Cells in the Developing Mouse Lung

1999 ◽  
Vol 47 (6) ◽  
pp. 823-831 ◽  
Author(s):  
Jay W. Tichelaar ◽  
Susan E. Wert ◽  
Robert H. Costa ◽  
Shioko Kimura ◽  
Jeffrey A. Whitsett
Keyword(s):  
Epithelial Cells ◽  
Mouse Lung ◽  
Ciliated Epithelial Cells

scholarly journals Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jennifer E. Cowan ◽  
Justin Malin ◽  
Yongge Zhao ◽  
Mina O. Seedhom ◽  
Christelle Harly ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
T Cell Development ◽  
Thymic Epithelial Cells ◽  
Fetal Life ◽  
Ribosomal Biogenesis ◽  
Transcriptional Program ◽  
Fetal Thymus ◽  
Thymus Development ◽  
And Function ◽  
Thymus Size

AbstractInteractions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that account for their age-specific properties, including proliferation rates, engraftability and function. Further analyses identify Myc as a regulator of fetal thymus development to support the rapid increase of thymus size during fetal life. Enforced Myc expression in TEC induces the prolonged maintenance of a fetal-specific transcriptional program, which in turn extends the growth phase of the thymus and enhances thymic output; meanwhile, inducible expression of Myc in adult TEC similarly promotes thymic growth. Mechanistically, this Myc function is associated with enhanced ribosomal biogenesis in TEC. Our study thus identifies age-specific transcriptional programs in TEC, and establishes that Myc controls thymus size.

scholarly journals STUDIES ON INFLUENZA INFECTION IN FERRETS BY MEANS OF FLUORESCEIN-LABELLED ANTIBODY

1955 ◽  
Vol 101 (6) ◽  
pp. 665-676 ◽  
Author(s):  
Ch'ien Liu
Keyword(s):  
Epithelial Cells ◽  
Influenza Infection ◽  
Bronchial Epithelium ◽  
Mediastinal Lymph Nodes ◽  
Viral Antigens ◽  
Antibody Staining ◽  
Hematoxylin And Eosin ◽  
Hematoxylin And Eosin Staining ◽  
Ciliated Epithelial Cells ◽  
Infectivity Titer

By means of fluorescein-labelled antibody staining, specific influenza viral antigens were seen in both the cytoplasm and the nucleus of infected ciliated epithelial cells covering the nasal turbinates of infected ferrets. Initially, only a small portion of the nasal epithelium showed fluorescence, and no appreciable abnormality of the cells could be detected by hematoxylin and eosin staining. The fluorescence soon spread to involve the entire epithelium, followed by desquamation coinciding with the onset of manifest illness. Pneumonia was seen in some of the infected ferrets, and in them, viral antigens were found in the bronchial epithelium and in the mediastinal lymph nodes. A rise of viral infectivity titer paralleled the observed spread of viral antigens. Many desquamated nasal epithelial cells and macrophages containing antigen were present in nasal smears. The finding would seem to offer a method for the rapid specific diagnosis of influenza infection.

scholarly journals Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells

2009 ◽  
Vol 331 (2) ◽  
pp. 486
Author(s):  
Philip B. Abitua ◽  
Tae Joo Park ◽  
Brian J. Mitchell ◽  
Chris Kintner ◽  
John B. Wallingford
Keyword(s):  
Epithelial Cells ◽  
Basal Bodies ◽  
Ciliated Epithelial Cells

scholarly journals Neurenteric Cysts Found on the Outer Membrane of a Subdural Haematoma

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Satoshi Takahashi ◽  
Yoshio Tanizaki ◽  
Kazunori Akaji ◽  
Tadashige Kano ◽  
Ban Mihara ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Outer Membrane ◽  
Subdural Haematoma ◽  
Chronic Subdural Haematoma ◽  
Burr Hole ◽  
Pathologic Examination ◽  
First Report ◽  
Underlying Causes ◽  
Ciliated Epithelial Cells

We report on a patient initially diagnosed with a chronic subdural haematoma that was resistant to treatment. After the second burr hole craniostomy within a half month failed to resolve the subdural haematoma (SDH), we performed a craniotomy to identify the point of bleeding. Macroscopic evaluation showed that most of the outer membrane of the SDH was transparent; however, further examination revealed the presence of multiple white regions. Pathologic examination showed that the white regions were fluid filled and surrounded by columnar ciliated epithelial cells. These lesions were pathologically diagnosed as neurenteric cysts. To our knowledge, this is the first report on a patient with neurenteric cysts found on the outer membrane of a CSDH. We agree that a craniotomy is a treatment of last resort for recurrent CSDHs; however, sometimes this procedure can be very useful for identifying underlying causes of obstinate SDHs as well as for their treatment.

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