scholarly journals High Throughput Phenotypic Selection of Mycobacterium tuberculosis Mutants with Impaired Resistance to Reactive Oxygen Species Identifies Genes Important for Intracellular Growth

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53486 ◽  
Author(s):  
Olga Mestre ◽  
Raquel Hurtado-Ortiz ◽  
Tiago Dos Vultos ◽  
Amine Namouchi ◽  
Mena Cimino ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mycobacterium Tuberculosis ◽  
High Throughput ◽  
Reactive Oxygen ◽  
Phenotypic Selection ◽  
Oxygen Species ◽  
Intracellular Growth ◽  
Selection Of

High-throughput spectrophotometric assay of reactive oxygen species in serum

2007 ◽  
Vol 631 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Ikue Hayashi ◽  
Yukari Morishita ◽  
Kazue Imai ◽  
Masakazu Nakamura ◽  
Kei Nakachi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
High Throughput ◽  
Reactive Oxygen ◽  
Spectrophotometric Assay ◽  
Oxygen Species

Reactive Oxygen Species (ROS)-Responsive Nanoprobe For Bioimaging And Targeted Therapy of Osteoarthritis

2021 ◽  
Author(s):  
Chong Shen ◽  
Ming Gao ◽  
Haimin Chen ◽  
Yanting Zhan ◽  
Qiumei Lan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cartilage Damage ◽  
Reactive Oxygen ◽  
Disease Classification ◽  
Oxygen Species ◽  
Stimulus Responsive ◽  
Targeting Peptide ◽  
Physiological Markers ◽  
Different Doses ◽  
Selection Of

Abstract Stimulus-responsive therapy that allows precise imaging-guided therapy is limited for osteoarthritis (OA) therapy due to the selection of proper physiological markers as stimulus. Based on that the over-production of Reactive Oxygen Species (ROS) is one of the leading causes of OA, we selected ROS as markers and designed a cartilage-targeting and ROS-responsive theranostic nanoprobe that is highly specific for effective bioimaging and therapy of OA. This nanoprobe was fabricated by using PEG micelles modified with ROS-sensitive thioketal linkers (TK) and cartilage-targeting peptide, termed TKC, which was then encapsulated with Dexamethasone (DEX) to form TKC@DEX nanoparticles. Results showed that the nanoprobe can smartly “turn on” in response to excessive ROS and “turn off” in the normal joint. By applying different doses of ROS inducer and ROS inhibitor, this nanoprobe can emit ROS-dependent fluorescence according to the degree of OA severity, helpful to precise disease classification in clinic. Specifically targeting cartilage, TKC@DEX could effectively respond to ROS and sustained release DEX to remarkably reduce cartilage damage in the OA joints. This smart, sensitive and endogenously activated ROS-responsive nanoprobe is promising for OA theranostics.

scholarly journals Selection of Functional Human Sperm with Higher DNA Integrity and Fewer Reactive Oxygen Species

2014 ◽  
Vol 3 (10) ◽  
pp. 1671-1679 ◽  
Author(s):  
Waseem Asghar ◽  
Vanessa Velasco ◽  
James L. Kingsley ◽  
Muhammad S. Shoukat ◽  
Hadi Shafiee ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Human Sperm ◽  
Dna Integrity ◽  
Oxygen Species ◽  
Selection Of

Roles of Reactive Oxygen Species in CXCL8 and CCL2 Expression in Response to the 30-kDa Antigen of Mycobacterium tuberculosis

2008 ◽  
Vol 29 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Hye-Mi Lee ◽  
Dong-Min Shin ◽  
Kwang-Kyu Kim ◽  
Ji-Sook Lee ◽  
Tae-Hyun Paik ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mycobacterium Tuberculosis ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ccl2 Expression

scholarly journals Recombinant Rv0753c Protein of Mycobacterium tuberculosis Induces Apoptosis Through Reactive Oxygen Species-JNK Pathway in Macrophages

2020 ◽  
Vol 50 (4) ◽  
pp. 246-256
Author(s):  
Kang-In Lee ◽  
Seunga Choi ◽  
Han-Gyu Choi ◽  
Sintayehu Gurmessa Kebede ◽  
Thi Binh Dang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mycobacterium Tuberculosis ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Jnk Pathway

scholarly journals Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death

ACS Omega ◽  
2017 ◽  
Vol 2 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Heather A. Howell Wescott ◽  
David M. Roberts ◽  
Christian L. Allebach ◽  
Rachel Kokoczka ◽  
Tanya Parish
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Mycobacterium Tuberculosis ◽  
Reactive Oxygen ◽  
Oxygen Species
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