scholarly journals The MPO−463G>A Polymorphism and Lung Cancer Risk: A Meta-Analysis Based on 22 Case–Control Studies

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65778 ◽  
Author(s):  
Jun-Ping Yang ◽  
Wen-Bo Wang ◽  
Xiao-Xi Yang ◽  
Lei Yang ◽  
Li Ren ◽  
...  
2010 ◽  
Vol 5 (9) ◽  
pp. 1337-1345 ◽  
Author(s):  
Ping Zhan ◽  
Qin Wang ◽  
Shu-Zhen Wei ◽  
Jing Wang ◽  
Qian Qian ◽  
...  

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Junjian Chen ◽  
Mao Sun ◽  
Min Zhou ◽  
Renfu Lu

Abstract Background We evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by performing a meta-analysis. Methods The heterogeneity in the study was tested using the Cochran χ2-based Q statistic test and I2 test, and then the random ratio or fixed effect was utilized to merge the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. Sensitivity analysis was also performed. Using funnel plot and Begg’s rank test, we investigated the publication bias. All statistical analyses were performed using Stata 12.0 and RevMan 5.3. Results A total of 4307 participants (2181 patients; 2126 controls) were included in the 12 case–control studies. No significant association was found between the ACE I/D polymorphism and lung cancer risk (II vs. ID + DD: OR = 1.22, 95% CI = 0.89–1.68; II + ID vs. DD: OR = 1.21, 95% CI = 0.90–1.63; I vs. D: OR = 1.15, 95% CI = 0.95–1.39). In the subgroup analysis by ethnicity, no significant association between the ACE I/D polymorphism and lung cancer risk was found among Asian and Caucasian populations for the comparisons of II vs. ID + DD, II + ID vs. DD, and I vs. D genetic models. Conclusion The ACE I/D polymorphism is not associated with the risk of lung cancer.


2015 ◽  
Vol 73 (2) ◽  
pp. 381-387 ◽  
Author(s):  
Dan Li ◽  
Ruoran Li ◽  
Jinghao Zhang ◽  
Ke Li ◽  
Yanmin Wu

2017 ◽  
Vol 6 (S5) ◽  
pp. S934-S943 ◽  
Author(s):  
Carmine Garzillo ◽  
Mariagabriella Pugliese ◽  
Filomena Loffredo ◽  
Maria Quarto

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e68457 ◽  
Author(s):  
Guohua Huang ◽  
Shaoxi Cai ◽  
Wei Wang ◽  
Qing Zhang ◽  
Aihua Liu

2012 ◽  
Vol 13 (6) ◽  
pp. 2459-2465 ◽  
Author(s):  
Zeng-Li Zhang ◽  
Jing Sun ◽  
Jia-Yi Dong ◽  
Hai-Lin Tian ◽  
Lian Xue ◽  
...  

2014 ◽  
Vol 136 (2) ◽  
pp. 360-371 ◽  
Author(s):  
Dario Consonni ◽  
Sara De Matteis ◽  
Angela C. Pesatori ◽  
Pier Alberto Bertazzi ◽  
Ann C. Olsson ◽  
...  

2017 ◽  
Vol 26 (9) ◽  
pp. 1367-1375 ◽  
Author(s):  
Beata Krusińska ◽  
Iwona Hawrysz ◽  
Małgorzata Słowińska ◽  
Lidia Wądołowska ◽  
Maciej Biernacki ◽  
...  

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