Vascular endothelial growth factor (VEGF) −2578C/A and −460C/T gene polymorphisms and lung cancer risk: a meta-analysis involving 11 case–control studies

Tumor Biology ◽  
2013 ◽  
Vol 35 (1) ◽  
pp. 859-870 ◽  
Author(s):  
Ning Song ◽  
Bao Liu ◽  
Jianling Wu ◽  
Rufang Zhang ◽  
Lin Duan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Gene Polymorphisms ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Vascular Endothelial ◽  
Case Control Studies ◽  
Endothelial Growth Factor

Vascular Endothelial Growth Factor (Vegf) +936 C/T Gene Polymorphisms and Gastric Cancer Risk: A Meta-Analysis Involving 4,138 Subjects

2010 ◽  
Vol 25 (4) ◽  
pp. 213-218 ◽  
Author(s):  
Yong Zhou ◽  
Wen Hu ◽  
Wen Zhuang ◽  
Guan-Jian Liu ◽  
Tai-Xiang Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Vascular Endothelial ◽  
Gastric Cancer Risk ◽  
Case Control Studies ◽  
Endothelial Growth Factor

The association between vascular endothelial growth factor (VEGF) +936 C/T gene polymorphisms and gastric cancer risk is still controversial and ambiguous. The objective of our study was to investigate this association. The Medline and Embase databases were searched by two investigators. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to test the association between VEGF +936 C/T polymorphisms and gastric cancer risk. Our meta-analysis comprised seven case-control studies, which included 1,893 gastric cancer cases and 2,245 controls. The combined results showed that there was no relationship between VEGF +936 C/T gene polymorphisms and gastric cancer risk (cc: OR 0.97, 95% CI 0.85, 1.11; CT: OR 1.01, 95% CI 0.88, 1.16; TT: OR 1.10, 95% CI 0.79, 1.55). Subgroup analysis by ethnicity and stage, location, and Lauren classification of gastric cancer did not change the results. This meta-analysis suggests that there is no association between VEGF +936 C/T polymorphisms and gastric cancer risk. Further studies should pay attention to other potentially functional SNPs.

scholarly journals A meta-analysis of the vascular endothelial growth factor polymorphisms associated with the risk of pre-eclampsia

2020 ◽  
Vol 40 (5) ◽  
Author(s):  
Weicheng Duan ◽  
Chenlu Xia ◽  
Kang Wang ◽  
Yijie Duan ◽  
Ping Cheng ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Vascular Endothelial ◽  
Vegf Gene ◽  
Case Control Studies ◽  
Increased Risk ◽  
Subgroup Analyses ◽  
Endothelial Growth Factor

Abstract Backgroud: Pre-eclampsia (PE) is a common pregnancy-induced hypertension disease. Some case–control studies reported the association between vascular endothelial growth factor (VEGF) gene polymorphisms (rs3025039, rs2010963) and PE risk. However, these associations were inconsistent in several studies. Therefore, we conducted this meta-analysis to assess the role of VEGF gene polymorphisms in PE more precisely. Methods: Eligible studies were searched in PubMed, Embase, Web of Science and Chinese (Chinese National Knowledge Infrastructure (CNKI) and WanFang) databases. Statistical analyses were performed by Stata 12.0 software. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. In addition, subgroup analyses, sensitive analyses and publication bias analyses were performed to further assess this meta-analysis. Results: In total, 21 studies were included in the meta-analysis covering 2018 cases and 2632 controls. There were significant associations between VEGF polymorphisms (rs3025039, rs2010963) and PE risk in the overall populations. In the subgroup analyses, we found that rs3025039 polymorphism was associated with the increased risk of PE among Chinese. As for rs2010963 polymorphism, a significant association was observed in subgroup of Caucasian. Conclusion: The present study suggested that the two VEGF gene polymorphisms (rs3025039, rs2010963) are associated with increased risk of PE in different ethnic groups, which means that the targets may be useful genetic markers for early prediction of PE.

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