scholarly journals Postantifungal Effect of Micafungin against the Species Complexes of Candida albicans and Candida parapsilosis

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132730 ◽  
Author(s):  
Sandra Gil-Alonso ◽  
Nerea Jauregizar ◽  
Elena Eraso ◽  
Guillermo Quindós
Keyword(s):  
Candida Albicans ◽  
Candida Parapsilosis ◽  
Species Complexes ◽  
Postantifungal Effect

Postantifungal effect of caspofungin against the Candida albicans and Candida parapsilosis clades

2016 ◽  
Vol 86 (2) ◽  
pp. 172-177 ◽  
Author(s):  
Sandra Gil-Alonso ◽  
Nerea Jauregizar ◽  
Elena Eraso ◽  
Guillermo Quindós
Keyword(s):  
Candida Albicans ◽  
Candida Parapsilosis ◽  
Postantifungal Effect

scholarly journals Characterizing the Effects of Caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

2006 ◽  
Vol 50 (7) ◽  
pp. 2569-2572 ◽  
Author(s):  
Cornelius J. Clancy ◽  
Hong Huang ◽  
Shaoji Cheng ◽  
Hartmut Derendorf ◽  
M. Hong Nguyen
Keyword(s):  
Candida Albicans ◽  
Candida Glabrata ◽  
Candida Parapsilosis ◽  
Measured Time ◽  
Time Kill ◽  
Postantifungal Effect

ABSTRACT We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.

scholarly journals Measurement of Voriconazole Activity against Candida albicans, C. glabrata, and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography

2007 ◽  
Vol 51 (8) ◽  
pp. 2985-2987 ◽  
Author(s):  
Yanjun Li ◽  
M. Hong Nguyen ◽  
Hartmut Derendorf ◽  
Shaoji Cheng ◽  
Cornelius J. Clancy
Keyword(s):  
High Performance Liquid Chromatography ◽  
Candida Albicans ◽  
Liquid Chromatography ◽  
High Performance ◽  
Candida Parapsilosis ◽  
Hplc Assay ◽  
Fungistatic Activity ◽  
Human Sera ◽  
Time Kill ◽  
Postantifungal Effect

ABSTRACT We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achievable in human sera. HPLC confirmed that experiments were conducted at the desired steady-state voriconazole concentrations.

scholarly journals Infecções oportunistas por leveduras e perfil enzimático dos agentes etiológicos

2009 ◽  
Vol 42 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Danielle Patrícia Cerqueira Macêdo ◽  
Aline Mary de Almeida Farias ◽  
Reginaldo Gonçalves de Lima Neto ◽  
Vanessa Karina Alves da Silva ◽  
André Ferraz Goiana Leal ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Candida Tropicalis ◽  
Candida Parapsilosis ◽  
Candida Guilliermondii ◽  
Candida Krusei

Infecções por leveduras são freqüentes em imunocomprometidos, contudo espécies emergentes têm alterado o perfil epidemiológico. A habilidade de secretar proteases tem sido associada à patogenicidade do gênero Candida. Esta pesquisa teve como objetivos diagnosticar leveduroses em pacientes imunocomprometidos e avaliar a virulência dos agentes etiológicos baseado em teste de secreção de protease utilizando soro de albumina bovina como substrato. Do total de 104 pacientes estudados, 19 apresentaram episódios de leveduroses. O trato respiratório (63,2%), seguido pelo trato urinário (10,5%) foram os locais mais comuns de infecção. Candida albicans, Candida parapsilosis, Candida tropicalis e espécies emergentes como Candida krusei e Candida guilliermondii foram isoladas. Cinco isolados de Candida parapsilosis e um de Candida albicans e Candida guilliermondii exibiram alta atividade enzimática. Concluímos que a caracterização enzimática de isolados de Candida pode ser um útil marcador prognóstico, especialmente em imunocomprometidos, uma vez que leveduroses nestes pacientes são geralmente graves.

scholarly journals Differential Activities of Newer Antifungal Agents against Candida albicans and Candida parapsilosis Biofilms

2007 ◽  
Vol 52 (1) ◽  
pp. 357-360 ◽  
Author(s):  
Αspasia Katragkou ◽  
Athanasios Chatzimoschou ◽  
Maria Simitsopoulou ◽  
Maria Dalakiouridou ◽  
Eudoxia Diza-Mataftsi ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Agents ◽  
Candida Parapsilosis ◽  
Planktonic Cells

ABSTRACT The activities of voriconazole, posaconazole, caspofungin, and anidulafungin against Candida albicans and Candida parapsilosis biofilms were evaluated. In contrast to planktonic cells, the MICs for voriconazole and posaconazole for the biofilms of the two species were high (≥256 and >64 mg/liter, respectively) but relatively low for the echinocandins caspofungin and anidulafungin (≤1 and ≤2 mg/liter, respectively).

scholarly journals Conserved and Divergent Roles of Bcr1 and CFEM Proteins in Candida parapsilosis and Candida albicans

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28151 ◽  
Author(s):  
Chen Ding ◽  
Genevieve M. Vidanes ◽  
Sarah L. Maguire ◽  
Alessandro Guida ◽  
John M. Synnott ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Candida Parapsilosis

scholarly journals INCIDENCES OF CANDIDA ALBICANS AND NON-ALBICANS AMONG CATHETER-ASSOCIATED URINARY TRACT INFECTION PATIENTS OF AKOLA CITY

2017 ◽  
Vol 10 (11) ◽  
pp. 115
Author(s):  
Khandare Ln ◽  
Barate Dl
Keyword(s):  
Urinary Tract Infection ◽  
Candida Albicans ◽  
Urinary Tract ◽  
Tract Infection ◽  
Candida Parapsilosis ◽  
Opportunistic Infections ◽  
Urine Samples ◽  
Age Group ◽  
Candida Spp ◽  
Catheter Urine

Objective: Candida spp. is the third leading cause of catheter-related infections. Candida species is a part of human microflora and it becomes pathogenic when certain conditions are present and cause an opportunistic infections. The present study was undertaken to determine incidences of Candida albicans and non-albicans among catheterized urinary tract infection (UTI) patients of Akola city.Methods: A total 60 catheter urine samples were collected from patient of all the age group and both sex who had indwelling urinary catheter. The collected catheterized urine samples of patients from various hospitals of Akola city were used for isolation using HiCrome Candida differential agar.Results: It was found that highest frequency of isolation of Candida spp. was from age group 61-70 years. The predominance of male candidate was more than female having Candida spp. in catheter-associated UTI (C-UTI). Among the Candida spp. C. albicans (64.81%) was predominant over non-albicans spp. while in non-albicans Candida krusei and Candida glabrata were predominant showing 11.11% incidences. It was followed by Candida tropicalis (9.2%) and Candida parapsilosis (3.7%).Conclusion: The incidences of C. albicans and non-albicans were high among catheter-associated UTI patients.

Extracellular Aspartic Proteinases from Candida albicans, Candida tropicalis, and Candida parapsilosis Yeasts Differ Substantially in Their Specificities

Biochemistry ◽  
1994 ◽  
Vol 33 (32) ◽  
pp. 9791-9799 ◽  
Author(s):  
Martin Fusek ◽  
Elizabeth A. Smith ◽  
Michael Monod ◽  
Ben M. Dunn ◽  
Stephen I. Foundling
Keyword(s):  
Candida Albicans ◽  
Candida Tropicalis ◽  
Candida Parapsilosis ◽  
Aspartic Proteinases
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