scholarly journals Correction: Edesign: Primer and Enhanced Internal Probe Design Tool for Quantitative PCR Experiments and Genotyping Assays

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152713
Author(s):  
PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0146950 ◽  
Author(s):  
Yasumasa Kimura ◽  
Takahiro Soma ◽  
Naoko Kasahara ◽  
Diane Delobel ◽  
Takeshi Hanami ◽  
...  

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51675 ◽  
Author(s):  
Jakub Nedbal ◽  
Philip S. Hobson ◽  
David J. Fear ◽  
Rainer Heintzmann ◽  
Hannah J Gould

2020 ◽  
Vol 29 (3) ◽  
pp. 1283-1300
Author(s):  
Xigrid T. Soto ◽  
Andres Crucet-Choi ◽  
Howard Goldstein

Purpose Preschoolers' phonological awareness (PA) and alphabet knowledge (AK) skills are two of the strongest predictors of future reading. Despite evidence that providing at-risk preschoolers with timely emergent literacy interventions can prevent academic difficulties, there is a scarcity of research focusing on Latinx preschoolers who are dual language learners. Despite evidence of benefits of providing Latinxs with Spanish emergent literacy instruction, few studies include preschoolers. This study examined the effects of a supplemental Spanish PA and AK intervention on the dual emergent literacy skills of at-risk Latinx preschoolers. Method A multiple probe design across four units of instruction evaluated the effects of a Spanish supplemental emergent literacy intervention that explicitly facilitated generalizations to English. Four Latinx preschoolers with limited emergent literacy skills in Spanish and English participated in this study. Bilingual researchers delivered scripted lessons targeting PA and AK skills in individual or small groups for 12–17 weeks. Results Children made large gains as each PA skill was introduced into intervention and generalized the PA skills they learned from Spanish to English. They also improved their English initial sound identification skills, a phonemic awareness task, when instruction was delivered in Spanish but with English words. Children made small to moderate gains in their Spanish letter naming and letter–sound correspondence skills and in generalizing this knowledge to English. Conclusion These findings provide preliminary evidence Latinx preschoolers who are dual language learners benefit from emergent literacy instruction that promotes their bilingual and biliterate development.


2010 ◽  
Vol 01 (03) ◽  
pp. 144-144
Author(s):  
Alexander Kretzschmar

Der Vorteil einer Konsolidierungstherapie mit 90Yttrium-Ibritumomab-Tiuxetan (Zevalin®) beim follikulären Lymphom (FL) wurde in der FIT-Studie anhand der Verbesserung des progressionsfreien Überlebens belegt. Eine quantitative PCR-Analyse (qPCR) der Studie zeigt nun einen weiteren Vorteil der Konsolidierung mit 90Yttrium- Ibritumomab-Tiuxetan: Der Antikörper führt bei 90% der initial bcl-2- positiven Patienten zur bcl-2- Negativität und parallel zu einer Verlängerung des progressionsfreien Überlebens auf über 40 Monate.


PCI Journal ◽  
2020 ◽  
Vol 65 (6) ◽  
pp. 35-61
Author(s):  
Chungwook Sim ◽  
Maher Tadros ◽  
David Gee ◽  
Micheal Asaad

Ultra-high-performance concrete (UHPC) is a special concrete mixture with outstanding mechanical and durability characteristics. It is a mixture of portland cement, supplementary cementitious materials, sand, and high-strength, high-aspect-ratio microfibers. In this paper, the authors propose flexural design guidelines for precast, prestressed concrete members made with concrete mixtures developed by precasters to meet minimum specific characteristics qualifying it to be called PCI-UHPC. Minimum specified cylinder strength is 10 ksi (69 MPa) at prestress release and 18 ksi (124 MPa) at the time the member is placed in service, typically 28 days. Minimum flexural cracking and tensile strengths of 1.5 and 2 ksi (10 and 14 MPa), respectively, according to ASTM C1609 testing specifications are required. In addition, strain-hardening and ductility requirements are specified. Tensile properties are shown to be more important for structural optimization than cylinder strength. Both building and bridge products are considered because the paper is focused on capacity rather than demand. Both service limit state and strength limit state are covered. When the contribution of fibers to capacity should be included and when they may be ignored is shown. It is further shown that the traditional equivalent rectangular stress block in compression can still be used to produce satisfactory results in prestressed concrete members. A spreadsheet workbook is offered online as a design tool. It is valid for multilayers of concrete of different strengths, rows of reinforcing bars of different grades, and prestressing strands. It produces moment-curvature diagrams and flexural capacity at ultimate strain. A fully worked-out example of a 250 ft (76.2 m) span decked I-beam of optimized shape is given.


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