scholarly journals Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies

PLoS ONE ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. e0225146
Author(s):  
Michele B. Daly ◽  
April M. Clayton ◽  
Susan Ruone ◽  
James Mitchell ◽  
Chuong Dinh ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Prevention ◽  
Rhesus Macaques ◽  
Treatment Strategies ◽  
Preclinical Evaluation ◽  
Prevention And Treatment

scholarly journals Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir

2021 ◽  
Vol 17 (6) ◽  
pp. e1009686
Author(s):  
Taina T. Immonen ◽  
Christine M. Fennessey ◽  
Leslie Lipkey ◽  
Abigail Thorpe ◽  
Gregory Q. Del Prete ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Viral Replication ◽  
Rhesus Macaques ◽  
Treatment Strategies ◽  
Viral Reservoir ◽  
Virus Population ◽  
Analytical Treatment ◽  
Treatment Interruptions ◽  
The Impact ◽  
Hiv 1

Analytical treatment interruptions (ATIs) of antiretroviral therapy (ART) play a central role in evaluating the efficacy of HIV-1 treatment strategies targeting virus that persists despite ART. However, it remains unclear if ATIs alter the rebound-competent viral reservoir (RCVR), the virus population that persists during ART and from which viral recrudescence originates after ART discontinuation. To assess the impact of ATIs on the RCVR, we used a barcode sequence tagged SIV to track individual viral lineages through a series of ATIs in Rhesus macaques. We demonstrate that transient replication of individual rebounding lineages during an ATI can lead to their enrichment in the RCVR, increasing their probability of reactivating again after treatment discontinuation. These data establish that the RCVR can be altered by uncontrolled replication during ATI.

scholarly journals Geospatial mapping to identify feasible HIV prevention and treatment strategies that target specific settings

2018 ◽  
Vol 6 (3) ◽  
pp. 59-59
Author(s):  
Paula M. Frew ◽  
Chelsea S. Lutz ◽  
Ighovwerha Ofotokun ◽  
Vincent C. Marconi ◽  
Carlos del Rio
Keyword(s):  
Hiv Prevention ◽  
Treatment Strategies ◽  
Prevention And Treatment ◽  
Geospatial Mapping

Evidence-Based Structural Interventions for HIV Prevention

2018 ◽  
pp. 179-190 ◽  
Author(s):  
S Sherman ◽  
K Hunter
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Prevention ◽  
Case Studies ◽  
Vulnerable Populations ◽  
Low Income ◽  
Sex Workers ◽  
Evidence Based ◽  
Image Study ◽  
Prevention And Treatment ◽  
Future Policy

Microenterprise approaches have been used in the context of both HIV prevention and treatment (e.g., adherence to antiretroviral therapy) with several highly vulnerable populations including women, female sex workers, and low-income HIV-positive individuals. This chapter defines and describes different approaches to microenterprise in the context of HIV prevention. The chapter also includes several case studies with vulnerable populations to evaluate the effectiveness of structural approaches to HIV prevention, including the IMAGE study, the Undarga study, the JEWEL study, and the Chennai study. The chapter concludes by outlining directions for future policy and research, including gaps and principles in research on HIV prevention.

Shifting the Paradigm in HIV Prevention and Treatment Service Delivery Toward Differentiated Care for Youth

2019 ◽  
Author(s):  
Vincent Guilamo-Ramos ◽  
Marco Thimm-Kaiser ◽  
Adam Benzekri ◽  
Donna Futterman
Keyword(s):  
United States ◽  
Hiv Prevention ◽  
Service Delivery ◽  
The United States ◽  
Hiv Care ◽  
Health Concern ◽  
Service Needs ◽  
Minority Adolescents ◽  
Prevention And Treatment ◽  
Differentiated Care

Despite significant progress in the fight against HIV/AIDS in the United States, HIV prevention and treatment disparities among key populations remain a national public health concern. While new HIV diagnoses are increasing among people under age 30—in particular among racial, ethnic, and sexual minority adolescents and young adults (AYA)—dominant prevention and treatment paradigms too often inadequately consider the unique HIV service needs of AYA. To address this gap, we characterize persistent and largely overlooked AYA disparities across the HIV prevention and treatment continuum, identify AYA-specific limitations in extant resources for improving HIV service delivery in the United States, and propose a novel AYA-centered differentiated care framework adapted to the unique ecological and developmental factors shaping engagement, adherence, and retention in HIV services among AYA. Shifting the paradigm for AYA to differentiated HIV care is a promising approach that warrants implementation and evaluation as part of reinforced national efforts to end the HIV epidemic in the United States by 2030.

Gender and Impulse Control Disorders

2012 ◽  
Author(s):  
Alexea Takacs ◽  
Sonia Madrid ◽  
Marc N. Potenza
Keyword(s):  
Impulse Control ◽  
Treatment Strategies ◽  
Impulse Control Disorders ◽  
Treatment Interventions ◽  
Prevention And Treatment

Although women and men (and girls and boys) share similarities, they also exhibit differences that may contribute to the etiology and development of impulse control disorders. Such differences may hold significant implications for the generation of optimal prevention and treatment strategies. In this chapter, we review data on gender-related differences in impulse control disorders, considering epidemiological, clinical, biological, and therapeutic perspectives. Implications for improving prevention and treatment interventions are discussed.

scholarly journals BK Virus Associated Haemorrhagic Cystitis. A systematic review of current prevention and treatment strategies

2019 ◽  
Vol 63 ◽  
pp. 34-42 ◽  
Author(s):  
M. Aldiwani ◽  
T. Tharakan ◽  
A. Al-Hassani ◽  
N. Gibbons ◽  
J. Pavlu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Treatment Strategies ◽  
Bk Virus ◽  
Haemorrhagic Cystitis ◽  
Prevention And Treatment
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