scholarly journals Effect of pegbovigrastim on clinical mastitis and uterine disease during a full lactation in grazing dairy cows

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252418
Author(s):  
Joaquín Barca ◽  
Ana Meikle ◽  
Mette Bouman ◽  
Giovanni Gnemmi ◽  
Rodrigo Ruiz ◽  
...  
Keyword(s):  
Body Condition ◽  
Treatment Effects ◽  
Body Condition Score ◽  
Controlled Trial ◽  
Healing Process ◽  
Clinical Mastitis ◽  
Uterine Disease ◽  
First Case ◽  
Condition Score ◽  
Peg Treatment

In this randomized controlled trial on four commercial grazing dairy farms, we investigated whether pegbovigrastim (PEG) treatment affects clinical mastitis (CM) and uterine disease (i.e. retained placenta (RP), metritis and endometritis) occurrence during a full lactation. The association of prepartum body condition score and prepartum non-esterified fatty acid (NEFA) concentration with disease occurrence was also evaluated. Holstein cows were randomly assigned to one of two treatments: first PEG dose approximately 7 d before the expected calving date and a second dose within 24 h after calving (PEG) compared to untreated controls (Control). In total, 2,153 animals were included in the study: 733 primiparous cows (Control = 391, PEG = 342) and 1420 multiparous cows (Control = 723, PEG = 697). Treatment effects were evaluated with generalized linear mixed models and Cox’s proportional hazard models. Treatment with PEG reduced the occurrence of a first case of CM during the first 30 days in milk (DIM) by 24.6% and reduced the hazard of a first case and the rate of total cases of CM during the full lactation. All PEG treatment effects were independent of parity. Prepartum body condition score interacted with PEG treatment: in over-conditioned cows, PEG reduced the occurrence of a first case of CM during the first 30 DIM by 49.5%. The hazard analysis of a first case of CM during the full lactation suggested that the preventive effect of PEG disappeared with increasing DIM. Treatment with PEG did not affect the occurrence of RP or metritis. Pegbovigrastim treated cows with metritis subsequently showed a reduced occurrence of endometritis compared to control cows with metritis. Pegbovigrastim reduces the occurrence of CM particularly in cows at risk of elevated lipid mobilization, and PEG ameliorates the uterine healing process in cows that experienced metritis.

scholarly journals ASSESSMENT OF SUBCLINICAL MASTITIS EFFECTS ON LIVE WEIGHT, BODY CONDITION SCORE (BCS) AND EXTERNAL UDDER MEASUREMENTS OF DORPER SHEEP

2021 ◽  
Vol 83 (2) ◽  
pp. 135-142
Author(s):  
Amirah Wan-Azemin ◽  
Asmad Kari ◽  
Nadiawati Alias
Keyword(s):  
Body Condition ◽  
Body Condition Score ◽  
Clinical Signs ◽  
Live Weight ◽  
Subclinical Mastitis ◽  
Clinical Mastitis ◽  
Condition Score ◽  
Dorper Sheep ◽  
Quality Of Milk

Mastitis is an inflammation of the mammary gland that can be classified as clinical and subclinical mastitis. The clinical mastitis can be diagnosed based on clinical signs, whilst subclinical mastitis mostly through somatic cell count (SCC). This study was carried out to determine the subclinical mastitis effects on live weight, body condition score (BCS) and external udder traits of Dorper sheep. A total 16 Dorper ewes were selected and screened for mastitis using the Californian mastitis test (CMT). The live weight, BCS and external udder traits (i.e. udder length (UL), udder width (UW), rear udder depth (RUD), cistern depth (CD) and teat length (TL) of the ewes were measured. The subclinical mastitis did not affect the live weight and BCS of Dorper ewes. Whilst for external udder measurements; the highest average of udder length, udder width, rear udder depth and cistern depth were indicated in CMT score as strong positive which shows that the measurement values of external ewes’ udder are increased when the strength detection of CMT scores increased and vice versa. However, all of the external udder parameters measured were not statistically (P>0.05) affected by the mastitis infection scores. The present results indicate that live weight, BCS and all external udder parameters did not influence the subclinical mastitis detected in the milk’s samples of the ewes. This study suggests that subclinical mastitis does not directly affected by morphology alteration of external udder traits, live weight or BCS, however it is likely affect the quality of milk produced.

scholarly journals Increase in white blood cell counts by pegbovigrastim in primiparous and multiparous grazing dairy cows and the interaction with prepartum body condition score and non-esterified fatty acids concentration

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245149
Author(s):  
Joaquín Barca ◽  
Ynte H. Schukken ◽  
Ana Meikle
Keyword(s):  
Blood Cell ◽  
Dairy Cows ◽  
Body Condition ◽  
White Blood Cell ◽  
Body Condition Score ◽  
Negative Association ◽  
Nefa Concentration ◽  
Condition Score ◽  
Peg Treatment ◽  
Grazing Dairy Cows

The objective of this study was to determine if parity affected the effect of pegbovigrastim (PEG) treatment on white blood cell (WBC) counts in grazing dairy cows. Additionally, the association of prepartum body condition score (BCS) and non-esterified fatty acid (Pre-NEFA) concentration with WBC counts was investigated. The effect of early-lactation disease was included in the statistical analysis. A randomized controlled trial on four commercial grazing dairy farms was performed. Holstein primiparous (Control = 87, PEG = 89) and multiparous (Control = 181, PEG = 184) cows were randomly assigned to one of two treatments: first PEG dose 8 ± 5 (mean ± SD) days before the expected calving date and a second dose within 24 h after calving (PEG) compared to untreated controls (Control). Treatment effects were evaluated with mixed linear regression models. Treatment with PEG increased WBC, neutrophil, lymphocyte and monocyte counts at 6 ± 1 (mean ± SD) days in milk. Parity, BCS and their interactions with treatment were not associated with WBC counts. In control cows, Pre-NEFA concentration was associated with reduced WBC, neutrophil and lymphocyte counts and tended to be associated with reduced monocyte counts. Pegbovigrastim treatment reversed the negative association of Pre-NEFA concentration with neutrophil and monocyte counts and tended to reverse the negative association of Pre-NEFA concentration with WBC counts. In the PEG treated group, cows diagnosed with retained placenta or metritis showed lower neutrophil counts when compared to PEG treated cows without these clinical diseases. These data confirm that PEG treatment increases WBC, neutrophil, lymphocyte and monocyte counts in grazing dairy cows and that this effect is independent of parity. Pegbovigrastim treatment reversed the negative association of Pre-NEFA concentration with neutrophil and monocyte counts, and tended to reverse the negative association of Pre-NEFA concentration with WBC counts.

17 THE EFFECT OF EXOGENOUS PROGESTERONE ON CONCEPTION RATE OF COOLED COWS DURING THE SUMMER AND AUTUMN

2009 ◽  
Vol 21 (1) ◽  
pp. 108 ◽  
Author(s):  
D. Wolfenson ◽  
E. Friedman ◽  
Y. Lavon ◽  
Z. Roth
Keyword(s):  
Body Condition ◽  
Body Condition Score ◽  
Visual Observation ◽  
Conception Rate ◽  
Uterine Disease ◽  
Variable Effect ◽  
Lactating Cows ◽  
Condition Score ◽  
Commercial Farms ◽  
Exogenous Progesterone

Dairy cows exhibit low concentrations of plasma progesterone during the summer. The effect of exogenous progesterone supplementation postinsemination (AI) in the summer on conception is equivocal. Moreover, the variability among studies in thermal stress severity contributes to the variable effect of exogenous progesterone on summer fertility. This study examined the effect of supplementing exogenous progesterone post-AI during the summer and autumn on conception rate of lactating cows that were efficiently cooled during the hot season. The study was conducted in Israel on 2 commercial farms of high-milk-producing cows, yielding, on average, 41.3 kg of milk day–1 around AI (124 days postpartum). These farms were equipped with efficient cooling systems along the feeding line and in the holding area. Mean body temperatures during the afternoon and evening hours in summer (air temperature and relative humidity of 30 to 32°C and 41 to 57%) were 39.1 ± 0.1°C, with a peak value of 39.5°C. Cows at first, second, or third AI that were inseminated after estrus (Day 0; detected by visual observation and computerized pedometric system; Afimilk, Israel) from July to August (summer) or September to October (fall) were included in the study (n = 377 cows). Treated cows (n = 181 cows) were fitted with an intravaginal device containing progesterone (CIDR) on Day 5 ± 1 after AI for 12 days; the device was removed on Day 17. Administration of the CIDR increased progesterone concentration by 2.3 ng mL–1 (P < 0.05). Conception rates were analyzed by a logistic regression procedure. Overall, the CIDR treatment increased conception rate by 6% compared with controls (39 v. 33%; NS). Day of CIDR insertion tended to affect conception rate (43, 39, and 34% for Days 4, 5, and 6, respectively; NS). The CIDR treatment significantly increased, compared with the control (+23%, P < 0.05), the conception rate of cows with a low body condition score at peak lactation (49.3 v. 26.6%). Similarly, the CIDR significantly increased (+22%, P < 0.05) the conception rate of cows that exhibited a uterine disorder at parturition (46.3 v. 24.6% in untreated control cows). The CIDR treatment also increased conception rate (NS) in the fall (+13%) in mature cows (+8%) and in the first AI (+12%). Similarly, cows treated with a CIDR before Day 120 postpartum, or cows yielding less than 40 kg of milk day–1 exhibited a numerically higher (+8%; NS) conception rate. Results indicated that exogenous progesterone administered post-AI increases conception during the summer and autumn in efficiently cooled cows during the hot months. The most beneficial effect was documented in cows that had been diagnosed as having a uterine disease postpartum, and in those that exhibited a low body condition score.

Energieaufnahme und Körpermasseentwicklung von Warmblutfohlen, die beim Absetzen den Betrieb wechseln

2014 ◽  
Vol 42 (04) ◽  
pp. 220-224
Author(s):  
J. K. Mack ◽  
H. P. Remler ◽  
E. Senckenberg ◽  
E. Kienzle
Keyword(s):  
Body Condition ◽  
Body Condition Score ◽  
Klinische Relevanz ◽  
Condition Score

Zusammenfassung Ziel der Studie war, den Energiebedarf von Warmblutfohlen zu überprüfen, die durch einen Betriebswechsel beim Absetzen erhöhtem Stress ausgesetzt sind. Material und Methoden: Neun Hengstfohlen, die als Absetzer von verschiedenen Züchtern gekauft und gemeinsam aufgestallt wurden, nahmen an der Studie vom Absetzen im Alter von etwa 6 Monaten bis zu einem Alter von etwa 1 Jahr teil. Das Absetzen erfolgte im heimischen Betrieb oder nach gemeinsamem Transport von Stute und Fohlen bei Ankunft im neuen Bestand. Die Fohlen erhielten Heulage (später erster Schnitt), Hafer und Fohlenaufzuchtfutter. Um eine individuelle Kraftfutterzuteilung zu ermöglichen, wurden die Fohlen zweimal täglich separat angebunden. Erhoben wurden die Gesamtaufnahme der Heulage aller Fohlen gemeinsam pro Tag, die tägliche individuelle Kraftfutteraufnahme sowie in 4-wöchigen Abständen Körpermasse und Body Condition Score (BCS). Ergebnisse: Die tägliche Energieaufnahme der Fohlen betrug 74 MJ verdauliche Energie (68 MJ umsetzbare Energie) pro Tier. Die Fohlen wurden mit vergleichsweise niedrigem BCS von 4,2 ± 0,4 (Skala von 1 bis 9) und einer durchschnittlichen Körpermasse von 285 ± 30 kg aufgestallt. Sie erreichten am Ende der Studie im Alter von 319 ± 22 Tagen eine Körpermasse von 326 ± 24 kg und einen BCS von 4,2 ± 0,4. Die Energieaufnahme der Fohlen war höher und ihre Gewichtsentwicklung langsamer als in einer parallel laufenden Studie mit Fohlen, die im Gestüt geboren und aufgewachsen und dementsprechend beim Absetzen weniger Stress ausgesetzt waren. Schlussfolgerung und klinische Relevanz: Fohlen mit relativ niedriger Körpermasse und BCS und erheblichem Stress zum Zeitpunkt des Absetzens benötigen deutlich mehr Energie als Fohlen, die beim Absetzen in ihrer gewohnten Umgebung verbleiben und dadurch weniger Stressoren unterliegen.

Fütterung von Hunden und Katzen in Deutschland

2012 ◽  
Vol 40 (06) ◽  
pp. 391-397 ◽  
Author(s):  
N. Dillitzer ◽  
C. Sauter-Louis ◽  
E. Kienzle ◽  
N. Becker
Keyword(s):  
Body Condition ◽  
Body Condition Score ◽  
Klinische Relevanz ◽  
Condition Score

Zusammenfassung Gegenstand und Ziel: Gewinn epidemiologischer Daten zur Fütterung von Hunden und Katzen in Deutschland. Material und Methoden: 865 Hundeund 243 Katzenbesitzer wurden anhand standardisierter Fragebögen zu ihrem Tier (Alter, Geschlecht, Gewicht, Ernährungszustand, Gesundheit), dessen Fütterung inklusive Belohnungen und Zusätzen, den Gründen für eine Futterumstellung und zur eigenen Person (Alter, Geschlecht, Schulbildung, Beruf) befragt. Die Befragungen fanden in Tierarztpraxen, Hundeschulen, Tierheimen, Parkanlagen und via Internet statt. Zudem wurde der Body Condition Score (BCS) der Tiere durch ihre Besitzer sowie die Interviewerin beurteilt. Ergebnisse: Das Durchschnittsalter der Hunde lag bei 4,8 Jahren, das der Katzen bei 6,8 Jahren. Das Gewicht reichte beim Hund von 2,2 bis 95 kg, bei der Katze von 2 bis 11 kg. Rund 52% der Hunde und Katzen waren übergewichtig (BCS 6–9). Zwischen der Beurteilung der Besitzer bzw. der Interviewerin gab es Differenzen. Viele Besitzer unterschätzten den BCS und erkannten vor allem beginnendes Übergewicht (BCS 6–7) nicht. 58% der Hundeund 90% der Katzenbesitzer verwendeten ausschließlich handelsübliche Fertigfutter, 35% bzw. knapp 10% kombinierten diese mit zusätzlichen Futtermitteln. Knapp 8% der Hundeund < 1% der Katzenbesitzer verfütterten selbst zubereitete Rationen. Ältere (> 7 Jahre) und kranke Hunde erhielten häufiger selbst hergestellte Rationen. Ältere Besitzer (≥ 46 Jahre) tendierten vermehrt dazu, das Futter selbst zuzubereiten, während die Schulbildung und die Berufstätigkeit keinen Einfluss auf die Fütterung hatten. Ein Zusammenhang zwischen Art der Fütterung und BCS bestand nicht. Besitzer mit geringerer Schulbildung sowie Hausfrauen und Rentner hatten häufiger übergewichtige Tiere. Futterbelohnungen erhielten 95% der Hunde und 65% der Katzen. Ältere und berufstätige Besitzer gaben prozentual seltener Belohnungen. Schlussfolgerungen: Übergewicht ist das größte ernährungsbedingte Problem. Im Vergleich zu früheren Studien hat sich die Zahl übergewichtiger Tiere erhöht. Klinische Relevanz: Tierbesitzer sollten frühzeitig auf Übergewicht hingewiesen werden, da sie den Beginn der Adipositas häufig nicht wahrnehmen. Die meisten Tierbesitzer verabreichen Belohnungen, was bei Diäten berücksichtigt werden muss.

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