scholarly journals Associations between low body mass index and mortality in patients with sepsis: A retrospective analysis of a cohort study in Japan

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252955
Author(s):  
Tetsuya Sato ◽  
Daisuke Kudo ◽  
Shigeki Kushimoto ◽  
Masatsugu Hasegawa ◽  
Fumihito Ito ◽  
...  

Background The distribution of body mass in populations of Western countries differs from that of populations of East Asian countries. In East Asian countries, fewer people have a high body mass index than those in Western countries. In Japan, the country with the highest number of older adults worldwide, many people have a low body mass index. Therefore, this study aimed to determine the association between a low body mass index and mortality in patients with sepsis in Japan. Methods We conducted this retrospective analysis of 548 patients with severe sepsis from a multicenter prospective observational study. Multivariate logistic regression analyses determined the association between body mass index and 28-day mortality adjusted for age, sex, pre-existing conditions, the occurrence of septic shock, Acute Physiology and Chronic Health Evaluation II scores, and Sequential Organ Failure Assessment scores. Furthermore, the association between a low body mass index and 28-day mortality was analyzed. Results The low body mass index group represented 18.8% of the study population (103/548); the normal body mass index group, 57.3% (314/548); and the high body mass index group, 23.9% (131/548), with the 28-day mortality rates being 21.4% (22/103), 11.2% (35/314), and 14.5% (19/131), respectively. In the low body mass index group, the crude and adjusted odds ratios (95% confidence intervals) for 28-day mortality relative to the non-low body mass index (normal and high body mass index groups combined) group were 2.0 (1.1–3.4) and 2.3 (1.2–4.2), respectively. Conclusion A low body mass index was found to be associated with a higher 28-day mortality than the non-low body mass index in patients with sepsis in Japan. Given that older adults often have a low body mass index, these patients should be monitored closely to reduce the occurrence of negative outcomes.

2010 ◽  
Author(s):  
Delaney Davis Downer ◽  
Aaron Jacobson ◽  
Erin Green ◽  
Claire Murphy

Author(s):  
Trisaptono Trisaptono ◽  
Sumintarsih Sumintarsih

and low body mass index. 2) differences in the effect of the circuit training method and interval training on increasing the VO2 Max Ability of Volleyball Players. 3) the difference in the VO2 Max ability of Volleyball Players between the circuit training method for high body mass index and the interval training method for high body mass index. 4) the difference in the VO2 Max Ability of Volleyball Players between the low body mass index circuit training method and the low body mass index training interval training method. 5) the effect of the interaction between body mass index and training methods on increasing the VO2 Max Ability of Volleyball Players. This study used a 2x2 factorial design experimental method. Population of Volleyball Club players Balangan Student Association, Sleman Yogyakarta. Total sample was 24 athletes. Data analysis techniques using ANAVA. The results: 1) There is a difference in effect between the circuit training method with a mean of 2.716666667, interval training with a mean of 3.655833333, on the increase in the VO2 Max ability of the mean difference of 0.939166666. 2) There is a difference in the effect between low body mass index with a mean of 3.844166667, high body mass index with a mean of 2.528333333 on the increase in the ability of VO2 max selisish by a mean of 1.315833334. 3) There is a difference in the effect of circuit training on average low Body Mass Index 3.001666667, interval training for low Body Mass Index with a mean of 4.686666667 on the increase in VO2 Max ability, a mean difference of 1.685. 4) there is a difference in the effect of circuit training on high Body Mass Index with a mean of 2.431666667, interval training for Body Mass Index with a mean height of 2.626 on the increase in VO2 max, a mean difference of 0.193333333 5) Interaction between Body Mass Index and exercise methods 1.45530676.


Author(s):  
Shanshan Ma ◽  
Yanchun Zhao ◽  
Danlei Lu ◽  
Xiujin Ye ◽  
Wanzhuo Xie

Abstract Objective Obesity increases the risk for many diseases, including some malignancies. We found that in diffuse large B-cell lymphoma, the most common form of non-Hodgkin’s lymphoma, patients with higher body mass index had significantly longer overall survival. Patients with peripheral T-cell lymphoma usually have worse outcomes than those with diffuse large B-cell lymphoma. Nonetheless, the association between body mass index at diagnosis and survival in patients with peripheral T-cell lymphoma remains unclear. Methods This retrospective study included 411 peripheral T-cell lymphoma patients from January 2010 to July 2017. Patients were stratified by body mass index into low body mass index (<24.0 kg/m2) and high body mass index (≥24.0 kg/m2) groups. We mainly used Cox modelling and the Kaplan–Meier method to evaluate survival and other variables. Results Multivariate analysis demonstrated that body mass index, international prognostic index and triglyceride level were independent prognostic factors of overall survival. Interestingly, patients with high body mass index had significantly longer overall survival (P < 0.01), with 69% of patients alive at 3 years versus 43% in the low body mass index group. Cox analysis showed reduced mortality in the high body mass index group compared with the low body mass index group (hazard ratio = 0.511, 95% CI, 0.309–0.846, P = 0.009). In addition, patients with high body mass index and low international prognostic index had the longest overall survival (P < 0.001). Conclusions High body mass index at the time of diagnosis was associated with improved overall survival in Chinese peripheral T-cell lymphoma patients.


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