The risk of laryngitis with herpes zoster infection: A nested case-control study using data from the Korean National Sample Cohort

Background Whether herpes zoster infection (HZI) affects laryngitis incidence remains unknown. Objective The purpose of this population-based retrospective study was to analyze the relationship between laryngitis and HZI using data from the Korean Health Insurance Review and Assessment Service—National Sample Cohort. Methods This study analyzed 1,197,093 medical claim codes from 2018. Patients with HZI (ICD-10: B02) were retrospectively identified. Laryngeal diseases were defined by ICD-10 codes for five subgroups: 1) malignant disease, 2) benign disease, 3) vocal cord palsy, 4) inflammatory disease, and 5) reflux disease. Results Among the Korean population older than 20 years, 12,809 experienced HZI. Subjects with HZI were more likely to be older (mean age: 51.54 years vs. 48.06 years, p <0.0001). The proportion of subjects with laryngeal disease was higher in those with HZI than in those without HZI (55.55% vs. 41.37%, p <0.0001). Laryngeal disease was significantly associated with HZI in multiple regression analysis (odds ratio (OR) = 1.77, 95% confidence interval: 1.71–1.84) after adjusting for age, sex, hypertension, diabetes, dyslipidemia, ischemic heart disease, cerebral stroke, and depression. Among laryngeal disease subgroups, inflammatory disease (OR = 1.05; 95% CI: 1.01–1.09) and reflux (OR = 1.20; 95% CI: 1.15–1.25) were associated with HZI. Conclusions HZI is independently associated with laryngitis. Results of this study have implications for etiological investigations and prevention strategies for laryngitis.

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Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study

American Journal of Alzheimer s Disease & Other Dementias® ◽

10.1177/15333175211006504 ◽

2021 ◽

Vol 36 ◽

pp. 153331752110065

Author(s):

Hyo Geun Choi ◽

Bum Jung Park ◽

Jae Sung Lim ◽

Song Yong Sim ◽

Yoon Jung Jung ◽

...

Keyword(s):

Herpes Zoster ◽

Case Control Study ◽

Matched Control ◽

National Sample ◽

Case Control ◽

Herpes Zoster Infection ◽

Neurodegenerative Dementia ◽

National Cohort ◽

Korean National Health Insurance ◽

Control Study

Objective: This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort. Methods: From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI. Results: The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84-0.97) in the dementia group. According to the subgroup analysis, the adjusted OR for HZI was 0.91 (95% confidence interval [CI] = 0.83 -1.00) in the < 80 years old group, 0.88 (95% CI = 0.78 -1.00) in the ≥ 80 years old group, 0.77 (95% CI = 0.66-0.89) in men and 0.96 (95% CI = 0.88 -1.05) in women. Conclusions: We concluded that HZI does not increase the risk of neurodegenerative dementia in individuals of any age or of either sex.

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Association between Herpes Zoster and Osteoporosis: A Nested Case-Control Study Using a National Sample Cohort

BioMed Research International ◽

10.1155/2019/4789679 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7

Author(s):

Chanyang Min ◽

Woo Jin Bang ◽

Dong Jun Oh ◽

Songyong Sim ◽

Hyo Geun Choi

Keyword(s):

Herpes Zoster ◽

Conditional Logistic Regression ◽

National Sample ◽

Chronic Inflammatory Disease ◽

Control Group ◽

Subgroup Analyses ◽

Region Of Residence ◽

Icd 10 ◽

Nested Case Control ◽

Age And Sex

Objectives. Chronic inflammatory disease might affect osteoporosis; however, few studies have reported the association between herpes zoster and osteoporosis. The goal of this study was to estimate the association between herpes zoster and osteoporosis in Korean residents. Methods. The Korean National Health Insurance Service-National Sample Cohort, which includes individuals aged ≥ 50 years, was assessed from 2002 to 2013. In total, 68,492 osteoporosis participants were matched with 68,492 control participants at a ratio of 1:1 by age, sex, income, and region of residence. We assayed the prior histories of herpes zoster in the osteoporosis and control groups. The diagnoses of herpes zoster and osteoporosis were based on ICD-10 codes and claim codes. Crude and adjusted models of odds ratios (ORs) were explored using conditional logistic regression analyses, and the 95% confidence intervals (CIs) were computed. The participants were stratified according to age, sex, income, and region of residence. Subgroup analyses were performed to investigate the role of age and sex. Results. The rate of herpes zoster in the osteoporosis group (5.1% [3,487/68,492]) was higher than that in the control group (4.0% [2,738/68,492]). The adjusted OR of herpes zoster in the osteoporosis group was 1.17 (95% CI = 1.11-1.24). In the subgroup analyses, the adjusted OR was 1.34 (95% CI = 1.01-1.78) among males aged < 65 years, 1.20 (95% CI = 1.12-1.29) among females aged < 65 years, and 1.19 (95% CI = 1.04-1.36) among males aged ≥ 65 years. Conclusion. The ORs of herpes zoster were increased among the osteoporosis patients. This correlation was reliable in all subgroups by age and sex except group of women ≥ 65 years old.

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