scholarly journals Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice

2019 ◽  
Vol 15 (4) ◽  
pp. e1007689 ◽  
Author(s):  
Vuong B. Lê ◽  
Julia Dubois ◽  
Christian Couture ◽  
Marie-Hélène Cavanagh ◽  
Olus Uyar ◽  
...  
Keyword(s):  
Human Metapneumovirus ◽  
Receptor Protein ◽  
Hydrophobic Protein ◽  
Small Hydrophobic Protein ◽  
Small Hydrophobic

scholarly journals Small Hydrophobic Protein of Human Metapneumovirus Does Not Affect Virus Replication and Host Gene Expression In Vitro

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58572 ◽  
Author(s):  
Miranda de Graaf ◽  
Sander Herfst ◽  
Jamil Aarbiou ◽  
Peter C. Burgers ◽  
Fatiha Zaaraoui-Boutahar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Virus Replication ◽  
Human Metapneumovirus ◽  
Host Gene ◽  
Host Gene Expression ◽  
Hydrophobic Protein ◽  
Small Hydrophobic Protein ◽  
Small Hydrophobic

scholarly journals Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells

Viruses ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 278 ◽  
Author(s):  
Xiaoyong Bao ◽  
Deepthi Kolli ◽  
Dana Esham ◽  
Thangam Velayutham ◽  
Antonella Casola
Keyword(s):  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Human Metapneumovirus ◽  
Hydrophobic Protein ◽  
Interferon Induction ◽  
Small Hydrophobic Protein ◽  
Small Hydrophobic

Topology and cellular localization of the small hydrophobic protein of avian metapneumovirus

2011 ◽  
Vol 160 (1-2) ◽  
pp. 102-107 ◽  
Author(s):  
Qiji Deng ◽  
Yuejin Weng ◽  
Wuxun Lu ◽  
Andrew Demers ◽  
Minxun Song ◽  
...  
Keyword(s):  
Cellular Localization ◽  
Avian Metapneumovirus ◽  
Hydrophobic Protein ◽  
Small Hydrophobic Protein ◽  
Small Hydrophobic

scholarly journals Mumps virus small hydrophobic protein targets ataxin-1 ubiquitin-like interacting protein (ubiquilin 4)

2010 ◽  
Vol 91 (11) ◽  
pp. 2773-2781 ◽  
Author(s):  
M. Woznik ◽  
C. Rodner ◽  
K. Lemon ◽  
B. Rima ◽  
A. Mankertz ◽  
...  
Keyword(s):  
Mumps Virus ◽  
Interacting Protein ◽  
Protein Targets ◽  
Hydrophobic Protein ◽  
Small Hydrophobic Protein ◽  
Small Hydrophobic

scholarly journals Human Metapneumovirus Small Hydrophobic Protein Inhibits NF-κB Transcriptional Activity

2008 ◽  
Vol 82 (16) ◽  
pp. 8224-8229 ◽  
Author(s):  
Xiaoyong Bao ◽  
Deepthi Kolli ◽  
Tianshuang Liu ◽  
Yichu Shan ◽  
Roberto P. Garofalo ◽  
...  
Keyword(s):  
Respiratory Tract Infections ◽  
Nuclear Translocation ◽  
Airway Epithelial Cells ◽  
Human Metapneumovirus ◽  
Airway Epithelial ◽  
Proinflammatory Mediators ◽  
Enhanced Secretion ◽  
Small Hydrophobic Protein ◽  
Tract Infections ◽  
Small Hydrophobic

ABSTRACT Human metapneumovirus, a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. In this study, we showed that infection of airway epithelial cells or mice with recombinant human metapneumovirus lacking SH expression (rhMPV-ΔSH) enhanced secretion of proinflammatory mediators, including interleukin 6 (IL-6) and IL-8, encoded by two NF-kB-dependent genes, compared to infection with wild-type rhMPV. RhMPV-ΔSH infection resulted in enhanced NF-kB-dependent gene transcription and in increased levels of phosphorylated and acetylated NF-kB without affecting its nuclear translocation, identifying a possible novel mechanism by which paramyxovirus SH proteins modulate NF-kB activation.

scholarly journals Characterization of three co-circulating genotypes of the small hydrophobic protein gene of mumps virus.

1998 ◽  
Vol 79 (12) ◽  
pp. 2929-2937 ◽  
Author(s):  
T Tecle ◽  
B Johansson ◽  
C Orvell ◽  
M Forsgren ◽  
A Jejcic
Keyword(s):  
Protein Gene ◽  
Mumps Virus ◽  
Hydrophobic Protein ◽  
Small Hydrophobic Protein ◽  
Small Hydrophobic
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