scholarly journals Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case–Cohort Study

2018 ◽  
Vol 64 (8) ◽  
pp. 1211-1220 ◽  
Author(s):  
Edward Yu ◽  
Christopher Papandreou ◽  
Miguel Ruiz-Canela ◽  
Marta Guasch-Ferre ◽  
Clary B Clish ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Quinolinic Acid ◽  
Kynurenic Acid ◽  
Hazard Ratio ◽  
Model Assessment ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Tryptophan Metabolites ◽  
Incident Cases

Abstract BACKGROUND Metabolites of the tryptophan–kynurenine pathway (i.e., tryptophan, kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic) may be associated with diabetes development. Using a case–cohort design nested in the Prevención con Dieta Mediterránea (PREDIMED) study, we studied the associations of baseline and 1-year changes of these metabolites with incident type 2 diabetes (T2D). METHODS Plasma metabolite concentrations were quantified via LC-MS for n = 641 in a randomly selected subcohort and 251 incident cases diagnosed during 3.8 years of median follow-up. Weighted Cox models adjusted for age, sex, body mass index, and other T2D risk factors were used. RESULTS Baseline tryptophan was associated with higher risk of incident T2D (hazard ratio = 1.29; 95% CI, 1.04–1.61 per SD). Positive changes in quinolinic acid from baseline to 1 year were associated with a higher risk of T2D (hazard ratio = 1.39; 95% CI, 1.09–1.77 per SD). Baseline tryptophan and kynurenic acid were directly associated with changes in homeostatic model assessment for insulin resistance (HOMA-IR) from baseline to 1 year. Concurrent changes in kynurenine, quinolinic acid, 3-hydroxyanthranilic acid, and kynurenine/tryptophan ratio were associated with baseline-to-1-year changes in HOMA-IR. CONCLUSIONS Baseline tryptophan and 1-year increases in quinolinic acid were positively associated with incident T2D. Baseline and 1-year changes in tryptophan metabolites predicted changes in HOMA-IR. Tryptophan levels may initially increase and then deplete as diabetes progresses in severity.

scholarly journals Association of Oily and Nonoily Fish Consumption and Fish Oil Supplements With Incident Type 2 Diabetes: A Large Population-Based Prospective Study

2021 ◽  
Author(s):  
Guo-Chong Chen ◽  
Rhonda Arthur ◽  
Li-Qiang Qin ◽  
Li-Hua Chen ◽  
Zhendong Mei ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fish Oil ◽  
Fish Consumption ◽  
Lower Risk ◽  
Large Population ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Oily Fish ◽  
Incident Cases

<b>OBJECTIVE </b> <p>To evaluate associations of oily and non-oily fish consumption and fish oil supplements with incident type 2 diabetes (T2D).</p> <p><b>RESEARCH DESIGN AND METHODS </b></p> <p>We included<a> 392,287 middle-aged and older participants </a>(55.0% women) in the UK Biobank who were free of diabetes, major cardiovascular disease, and cancer, and had information on habitual intake of major food groups and use of fish oil supplements at baseline (<a>2006-2010</a>). Of these, <a>163,706</a> participated in 1-5 rounds of 24-h dietary recalls during 2009-2012. </p> <p><b>RESULTS</b></p> <p>During a median 10.1 years of follow-up, <a>7,262</a> incident cases of T2D were identified. As compared with participants who reported never consumption of oily fish, the multivariable-adjusted hazard ratios (95% CI) of T2D were 0.84 (0.78-0.91), 0.78 (0.72-0.85), and 0.78 (0.71-0.86) for those who reported <1 serving/week, weekly, and ≥2 servings/week of oily fish consumption, respectively (P-trend <0.001). Consumption of non-oily fish was not associated with risk of T2D (P-trend = 0.45). Participants who reported regular fish oil use at baseline had a 9% (95% CI: 4%-14%) lower risk of T2D as compared with non-users. Baseline regular users of fish oil who also reported fish oil use during at least one of the 24-h dietary recalls had an 18% (95% CI: 8%-27%) lower risk of T2D when compared with constant non-users.</p> <p><b>CONCLUSIONS</b></p> Our findings suggest that consumption of oily fish, but not non-oily fish, was associated with a lower risk of T2D. Use of fish oil supplements, especially constant use over time, was also associated with a lower risk of T2D.

scholarly journals Proinsulin to insulin ratio is associated with incident type 2 diabetes but not with vascular complications in the KORA F4/FF4 study

2020 ◽  
Vol 8 (1) ◽  
pp. e001425
Author(s):  
Cornelia Then ◽  
Christina Gar ◽  
Barbara Thorand ◽  
Cornelia Huth ◽  
Holger Then ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Vascular Complications ◽  
Model Assessment ◽  
Incident Type ◽  
The Metabolic Syndrome ◽  
Incident Type 2 Diabetes

IntroductionWe investigated the association of the proinsulin to insulin ratio (PIR) with prevalent and incident type 2 diabetes (T2D), components of the metabolic syndrome, and renal and cardiovascular outcomes in the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study (2006–2008)/FF4 study (2013–2014).Research design and methodsThe analyses included 1514 participants of the KORA F4 study at baseline and 1132 participants of the KORA FF4 study after a median follow-up time of 6.6 years. All-cause and cardiovascular mortality as well as cardiovascular events were analyzed after a median time of 9.1 and 8.6 years, respectively. The association of PIR with T2D, renal and cardiovascular characteristics and mortality were assessed using logistic regression models. Linear regression analyses were used to assess the association of PIR with components of the metabolic syndrome.ResultsAfter adjustment for sex, age, body mass index (BMI), and physical activity, PIR was associated with prevalent (OR: 2.24; 95% CI 1.81 to 2.77; p<0.001) and incident T2D (OR: 1.66; 95% CI 1.26 to 2.17; p<0.001). PIR was associated with fasting glucose (β per SD: 0.11±0.02; p<0.001) and HbA1c (β: 0.21±0.02; p<0.001). However, PIR was not positively associated with other components of the metabolic syndrome and was even inversely associated with waist circumference (β: −0.22±0.03; p<0.001), BMI (β: −0.11±0.03; p<0.001) and homeostatic model assessment of insulin resistance (β: −0.22±0.02; p<0.001). PIR was not significantly associated with the intima-media thickness (IMT), decline of kidney function, incident albuminuria, myocardial infarction, stroke, cardiovascular or all-cause mortality.ConclusionsIn the KORA F4/FF4 cohort, PIR was positively associated with prevalent and incident T2D, but inversely associated with waist circumference, BMI and insulin resistance, suggesting that PIR might serve as a biomarker for T2D risk independently of the metabolic syndrome, but not for microvascular or macrovascular complications.

scholarly journals Role of HDL Cholesterol and Estimates of HDL Particle Composition in Future Development of Type 2 Diabetes in the General Population: The PREVEND Study

2013 ◽  
Vol 98 (8) ◽  
pp. E1352-E1359 ◽  
Author(s):  
Ali Abbasi ◽  
Eva Corpeleijn ◽  
Ron T. Gansevoort ◽  
Rijk O. B. Gans ◽  
Hans L. Hillege ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
High Density ◽  
High Density Lipoproteins ◽  
Particle Composition ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Incident Cases

Background and Aims: High-density lipoproteins (HDLs) may directly stimulate β-cell function and glucose metabolism. We determined the relationships of fasting high-density lipoprotein cholesterol (HDL-C), plasma apolipoprotein (apo) A-I and apoA-II, and HDL-C–to–apoA-I and HDL-C–to–apoA-II ratios, as estimates of HDL particle composition, with incident type 2 diabetes mellitus. Methods: A prospective study was carried out in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort after exclusion of subjects with diabetes at baseline (n = 6820; age, 28–75 years). The association of HDL-related variables with incident type 2 diabetes was determined by multivariate logistic regression analyses. Results: After a median follow-up of 7.7 years, 394 incident cases of type 2 diabetes mellitus were ascertained (5.8%). After adjustment for age, sex, family history of diabetes, body mass index, hypertension, alcohol, and smoking, odd ratios (ORs) for diabetes were 0.55 (95% confidence interval [CI], 0.47–0.64; P &lt; .001), 0.81 (0.71–0.93; P = .002), 0.02 (0.01–0.06; P &lt; .001), and 0.03 (0.01–0.060; P &lt; .001) per 1-SD increase in HDL-C and apoA-I and in the HDL-C–to–apoA-I and the HDL-C–to–apoA-II ratios, respectively. In contrast, apoA-II was not related to incident diabetes (OR = 1.02; 95% CI, 0.90–1.16; P=0.71). The relationships of HDL-C and the ratios of HDL-C to apoA-I and HDL-C to apoA-II remained significant after further adjustment for baseline glucose and triglycerides (ORHDL = 0.74 [95% CI, 0.61–0.88], ORHDL/APO A-I = 0.14 [0.04–0.44], and ORHDL/APOA-II = 0.12 [0.04–0.36]; all P ≤ .001). Conclusions: Higher HDL-C, as well as higher HDL-C–to–apoA-I and HDL-C–to–apoA-II ratios are strongly and independently related to a lower risk of future type 2 diabetes.

scholarly journals Association of Oily and Nonoily Fish Consumption and Fish Oil Supplements With Incident Type 2 Diabetes: A Large Population-Based Prospective Study

2021 ◽  
Author(s):  
Guo-Chong Chen ◽  
Rhonda Arthur ◽  
Li-Qiang Qin ◽  
Li-Hua Chen ◽  
Zhendong Mei ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fish Oil ◽  
Fish Consumption ◽  
Lower Risk ◽  
Large Population ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Oily Fish ◽  
Incident Cases

<b>OBJECTIVE </b> <p>To evaluate associations of oily and non-oily fish consumption and fish oil supplements with incident type 2 diabetes (T2D).</p> <p><b>RESEARCH DESIGN AND METHODS </b></p> <p>We included<a> 392,287 middle-aged and older participants </a>(55.0% women) in the UK Biobank who were free of diabetes, major cardiovascular disease, and cancer, and had information on habitual intake of major food groups and use of fish oil supplements at baseline (<a>2006-2010</a>). Of these, <a>163,706</a> participated in 1-5 rounds of 24-h dietary recalls during 2009-2012. </p> <p><b>RESULTS</b></p> <p>During a median 10.1 years of follow-up, <a>7,262</a> incident cases of T2D were identified. As compared with participants who reported never consumption of oily fish, the multivariable-adjusted hazard ratios (95% CI) of T2D were 0.84 (0.78-0.91), 0.78 (0.72-0.85), and 0.78 (0.71-0.86) for those who reported <1 serving/week, weekly, and ≥2 servings/week of oily fish consumption, respectively (P-trend <0.001). Consumption of non-oily fish was not associated with risk of T2D (P-trend = 0.45). Participants who reported regular fish oil use at baseline had a 9% (95% CI: 4%-14%) lower risk of T2D as compared with non-users. Baseline regular users of fish oil who also reported fish oil use during at least one of the 24-h dietary recalls had an 18% (95% CI: 8%-27%) lower risk of T2D when compared with constant non-users.</p> <p><b>CONCLUSIONS</b></p> Our findings suggest that consumption of oily fish, but not non-oily fish, was associated with a lower risk of T2D. Use of fish oil supplements, especially constant use over time, was also associated with a lower risk of T2D.

scholarly journals Opposing associations of NT-proBNP with risks of diabetes and diabetes-related complications

2020 ◽  
Author(s):  
Anna Birukov ◽  
Fabian Eichelmann ◽  
Olga Kuxhaus ◽  
Elli Polemiti ◽  
Andreas Fritsche ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Diabetes Risk ◽  
Macrovascular Complications ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Design And Methods ◽  
Incident Cases ◽  
Healthy Participants

<b>Objective:</b> Circulating N-terminal pro b-type natriuretic peptide (NT-proBNP) is a classic diagnostic and prognostic marker for heart failure. However, it is inversely associated with diabetes risk. We aimed to investigate relationships of NT-proBNP with risk of diabetes-related complications in initially healthy individuals. <p><b>Research Design and Methods:</b> <a>We performed a case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort including a random subcohort (n=1294) and incident cases of type 2 diabetes (n=649) and cardiovascular diseases (CVD, n=478). Incident cases of type 2 diabetes (n=545) were followed up for micro- (n=133) and macrovascular (n=50) complications. Plasma NT-proBNP was measured at baseline in initially healthy participants.</a></p> <p><b>Results: </b><a></a><a>In multivariable models, NT-proBNP was linearly inversely associated with incident type 2 diabetes, HR (95% CI) per doubling in NT-proBNP: 0.91 (0.86; 0.98). The association was only observable in women, HR (95%CI): 0.80 (0.72; 0.90), compared to 0.98 (0.91; 1.07) in men. Among persons with incident diabetes, NT-proBNP was positively associated with diabetes complications, HR (95% CI): 1.31 (1.13; 1.53) for overall, 1.20 (1.01; 1.43) for micro- and 1.37 (1.03; 1.83) for macrovascular complications. </a></p> <b>Conclusions: </b><a>Although higher NT-proBNP levels are associated with lower diabetes risk, in persons who develop diabetes NT-proBNP is a biomarker for vascular complications independent of potential confounders. </a><a>Thus, NT-proBNP might be informative to monitor risk for diabetes-related micro- and macrovascular complications, which should be further explored in future prospective studies.</a>

P2493Change in cardiovascular health and incident type 2 diabetes and prediabetes: The Whitehall II Study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
R Climie ◽  
T T Van Sloten ◽  
M C Perier ◽  
M Tafflet ◽  
A Fayosse ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Health ◽  
Heart Association ◽  
Single Measure ◽  
Incident Type ◽  
Ideal Metrics ◽  
Incident Type 2 Diabetes ◽  
Fasting Glycaemia ◽  
Incident Cases

Abstract Background Most previous studies on cardiovascular health (CVH) and incident type 2 diabetes (T2D) used a single measure of CVH and none investigated the association with incident prediabetes. This study aimed to examine whether changes in CVH are associated with incident T2D and prediabetes. Methods Within the prospective Whitehall II study, CVH was examined serially every 5 years from 1991/93 until 2015/16. Subjects with 0–2, 3–4 and 5–6 ideal metrics of CVH from the American Heart Association (non-smoking, and ideal levels of body mass index, physical activity, diet, blood pressure, and total cholesterol, fasting glycaemia was not considered),were categorized as having low, moderate or high CVH. Results There were 6234 participants without prior cardiovascular disease and T2D (mean age 49.8±6.0 years, 70% male) including 5015 who were additionally free of prediabetes (49.6±6.0 years, 67% male) at baseline. Over a median follow-up of 24.8 (IQR 24.0 to 25.2) years, 895 and 1703 incident cases of T2D and prediabetes occurred respectively. Change in CVH between 1991/93 and 2002/04 was calculated among 4470 participants without CVD and T2D in the interval, and among 2798 participants additionally free of prediabetes. In multivariate analysis, compared to those with stable low CVH, risk of T2D was lower in those with initially high CVH (HR=0.23; 0.09, 0.56), those who had persistently moderate CVH or changed from moderate to high CVH (moderate-moderate/high; HR=0.42; 0.33, 0.54), low-moderate/high (HR=0.50; 0.36, 0.69) and moderate-low (HR=0.63; 0.48, 0.83). Results were similar for prediabetes, but effect sizes were smaller. Conclusions Among participants without previous CVD, T2D or prediabetes, change in CVH was related to the risk of incident T2D and prediabetes.

scholarly journals Opposing associations of NT-proBNP with risks of diabetes and diabetes-related complications

2020 ◽  
Author(s):  
Anna Birukov ◽  
Fabian Eichelmann ◽  
Olga Kuxhaus ◽  
Elli Polemiti ◽  
Andreas Fritsche ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Diabetes Risk ◽  
Macrovascular Complications ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Design And Methods ◽  
Incident Cases ◽  
Healthy Participants

<b>Objective:</b> Circulating N-terminal pro b-type natriuretic peptide (NT-proBNP) is a classic diagnostic and prognostic marker for heart failure. However, it is inversely associated with diabetes risk. We aimed to investigate relationships of NT-proBNP with risk of diabetes-related complications in initially healthy individuals. <p><b>Research Design and Methods:</b> <a>We performed a case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort including a random subcohort (n=1294) and incident cases of type 2 diabetes (n=649) and cardiovascular diseases (CVD, n=478). Incident cases of type 2 diabetes (n=545) were followed up for micro- (n=133) and macrovascular (n=50) complications. Plasma NT-proBNP was measured at baseline in initially healthy participants.</a></p> <p><b>Results: </b><a></a><a>In multivariable models, NT-proBNP was linearly inversely associated with incident type 2 diabetes, HR (95% CI) per doubling in NT-proBNP: 0.91 (0.86; 0.98). The association was only observable in women, HR (95%CI): 0.80 (0.72; 0.90), compared to 0.98 (0.91; 1.07) in men. Among persons with incident diabetes, NT-proBNP was positively associated with diabetes complications, HR (95% CI): 1.31 (1.13; 1.53) for overall, 1.20 (1.01; 1.43) for micro- and 1.37 (1.03; 1.83) for macrovascular complications. </a></p> <b>Conclusions: </b><a>Although higher NT-proBNP levels are associated with lower diabetes risk, in persons who develop diabetes NT-proBNP is a biomarker for vascular complications independent of potential confounders. </a><a>Thus, NT-proBNP might be informative to monitor risk for diabetes-related micro- and macrovascular complications, which should be further explored in future prospective studies.</a>

[beta]eta-hydroxybutyrate and risk for incident type 2 diabetes: results from the prevend prospective cohort study

2019 ◽  
Author(s):  
Jose L Flores-Guerrero ◽  
Margery A Connelly ◽  
Dion Groothof ◽  
Eke G Gruppen ◽  
Stephan JL Bakker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes
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