scholarly journals The Danish Twin Registry: 127 Birth Cohorts of Twins

Twin Research ◽  
2002 ◽  
Vol 5 (5) ◽  
pp. 352-357 ◽  
Author(s):  
Axel Skytthe ◽  
Kirsten Kyvik ◽  
Niels V. Holm ◽  
James W. Vaupel ◽  
Kaare Christensen
Keyword(s):  
Birth Cohorts ◽  
Twin Registry ◽  
Danish Twin

scholarly journals The Danish Twin Registry: An Updated Overview

2019 ◽  
Vol 22 (6) ◽  
pp. 499-507 ◽  
Author(s):  
Dorthe Almind Pedersen ◽  
Lisbeth Aagaard Larsen ◽  
Marianne Nygaard ◽  
Jonas Mengel-From ◽  
Matt McGue ◽  
...  
Keyword(s):  
Biological Samples ◽  
Twin Studies ◽  
Molecular Data ◽  
Short Description ◽  
Repeated Measurements ◽  
Birth Cohorts ◽  
Twin Registry ◽  
Wide Range ◽  
The World ◽  
Danish Twin

AbstractThe Danish Twin Registry (DTR) was established in the 1950s, when twins born from 1870 to 1910 were ascertained, and has since been extended to include twins from birth cohorts until 2009. The DTR currently comprises of more than 175,000 twins from the 140 birth cohorts. This makes the DTR the oldest nationwide twin register and among the largest in the world. The combination of data from several surveys, including biological samples and repeated measurements on the same individuals, and data from Danish national registers provides a unique resource for a wide range of twin studies. This article provides an updated overview of the data in the DTR: First, we provide a summary of the establishment of the register, the different ascertainment methods and the twins included; then follows an overview of major surveys conducted in the DTR since 1994 and a description of the DTR biobank, including a description of the molecular data created so far; finally, a short description is given of the linkage to Danish national registers at Statistics Denmark and some recent examples of studies using the various data resources in the DTR are highlighted.

scholarly journals The Danish Twin Registry: Linking Surveys, National Registers, and Biological Information

2012 ◽  
Vol 16 (1) ◽  
pp. 104-111 ◽  
Author(s):  
Axel Skytthe ◽  
Lene Christiansen ◽  
Kirsten Ohm Kyvik ◽  
Frans L. Bødker ◽  
Lars Hvidberg ◽  
...  
Keyword(s):  
First Century ◽  
Biological Information ◽  
Research Directions ◽  
Ongoing Research ◽  
New Developments ◽  
Twin Registry ◽  
New Research ◽  
Health Registers ◽  
Data Collection Effort ◽  
Danish Twin

Over the last 60 years, the resources and the research in the Danish Twin Registry (DTR) have periodically been summarized. Here, we give a short overview of the DTR and a more comprehensive description of new developments in the twenty-first century. First, we outline our experience over the last decade of combining questionnaire and survey data with national demographic, social, and health registers in Statistics Denmark. Second, we describe our most recent data collection effort, which was conducted during the period 2008–2011 and included both in-person assessments of 14,000+ twins born 1931–1969 and sampling of biological material, hereby expanding and consolidating the DTR biobank. Third, two examples of intensively studied twin cohorts are given. The new developments in the DTR in the last decade have facilitated the ongoing research and laid the groundwork for new research directions.

scholarly journals The Danish Twin Registry in the New Millennium

2006 ◽  
Vol 9 (6) ◽  
pp. 763-771 ◽  
Author(s):  
Axel Skytthe ◽  
Kirsten Kyvik ◽  
Lise Bathum ◽  
Niels Holm ◽  
James W. Vaupel ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Normal Variation ◽  
New Developments ◽  
The Metabolic Syndrome ◽  
Twin Registry ◽  
Age Related ◽  
The World ◽  
Health Related ◽  
Danish Twin

AbstractThe Danish Twin Registry is the oldest national twin register in the world, initiated in 1954, and, by the end of 2005, contained more than 75,000 twin pairs born in the between 1870 and 2004. The Danish Twin Registry is used as a source for studies on the genetic influence on normal variation in clinical parameters associated with the metabolic syndrome and cardiovascular diseases, clinical studies of specific diseases, and aging and age-related health problems. The combination of survey data, clinical data and linkage to national health-related registers enables follow-up studies of both the general twin population and twins from clinical studies. This paper summarizes the newest extension of the register and gives examples of new developments and phenotypes studied.

Genetics Play a Role in Diverticular Disease: Results From the Danish Twin Registry

2011 ◽  
Vol 140 (5) ◽  
pp. S-90
Author(s):  
Lisa L. Strate ◽  
Rune Erichsen ◽  
John A. Baron ◽  
Jakob Mortensen ◽  
Jacob K. Pedersen ◽  
...  
Keyword(s):  
Diverticular Disease ◽  
Twin Registry ◽  
Danish Twin

scholarly journals Twins and Their Health Cost: Consequences of Multiple Births on Parental Health and Mortality in Denmark and England and Wales

2006 ◽  
Vol 9 (3) ◽  
pp. 444-449 ◽  
Author(s):  
Cecilia Tomassini ◽  
Emily Grundy ◽  
Axel Skytthe ◽  
Kaare Christensen
Keyword(s):  
Excess Mortality ◽  
Developed Countries ◽  
Population Register ◽  
Danish Population ◽  
England And Wales ◽  
Slight Excess ◽  
Twin Registry ◽  
Health And Mortality ◽  
Danish Twin

AbstractThe rapid increase in twinning rates in developed countries has increased interest in the question as to whether twin mothers have higher mortality and more health problems than mothers of singletons. Here we use a national survey, the Office for National Statistics Longitudinal Study of England & Wales, and a linkage between the Danish Twin Registry and the Danish population register to examine mortality patterns after age 45 (50 for fathers) for twin parents and the whole population born from 1911 to 1950. For England and Wales, presence of limiting long-term illnesses and self-rated health status was also investigated. Overall similar health and mortality was found for twin parents and the whole population although both life table methods and survival analysis suggested a slight excess mortality among older cohorts of twin mothers in England and Wales.

scholarly journals The Danish Twin Registry

2011 ◽  
Vol 39 (7_suppl) ◽  
pp. 75-78 ◽  
Author(s):  
Axel Skytthe ◽  
Kirsten Ohm Kyvik ◽  
Niels Vilstrup Holm ◽  
Kaare Christensen
Keyword(s):  
Twin Registry ◽  
Danish Twin

scholarly journals Chromosomal Aberrations in Monozygotic and Dizygotic Twins Versus Singletons in Denmark During 1968–2009

2017 ◽  
Vol 20 (3) ◽  
pp. 216-225
Author(s):  
Lone Kroeldrup ◽  
Lisbeth A. Larsen ◽  
Christina Fagerberg ◽  
Jens M. Hertz ◽  
Kaare Christensen
Keyword(s):  
Chromosomal Aberrations ◽  
Monozygotic Twinning ◽  
Twin Registry ◽  
Central Register ◽  
Increased Risk ◽  
Embryologic Development ◽  
Prevalence Proportion ◽  
Mz Twins ◽  
Similar Risk ◽  
Danish Twin

Background: Hall (Embryologic development and monozygotic twinning. Acta Geneticae Medicae et Gemellologiae, Vol. 45, 1996, pp. 53–57) hypothesized that chromosomal aberrations can lead to monozygotic (MZ) twinning. However, twinning and chromosomal aberrations increase prenatal mortality and could reduce the prevalence of chromosomal aberrations in live-born twins. We compared prevalence proportion ratios (PPR) of chromosomal aberrations and trisomy 21 (T21) in live-born twins versus singletons born in Denmark during 1968–2009. Methods: We linked the Danish Twin Registry and a 5% random sample of all singletons to the Danish Cytogenetic Central Register and calculated PPR adjusted for maternal age for MZ, dizygotic (DZ), and all twins versus singletons. Zygosity was based on questionnaires or genetic markers. Results: No overall difference in risk of chromosomal aberrations or T21 in twins versus singletons was found. PPR in MZ and DZ twins was 0.87 (95% CI [0.60, 1.27]) and 1.05 (95% CI [0.88, 1.27]), respectively. For T21 there was a tendency to a lower prevalence in MZ twins compared to singletons (PPR: 0.29, 95% CI [0.07, 1.14]), whereas PPR was significantly increased in DZ twins (1.62, 95% CI [1.20, 2.19]). The observed proportion of MZ twin pairs among twin pairs with aberrations (0.22, 95% CI [0.16, 0.28]) was significantly lower than the proportion expected from the Weinberg method (0.32, 95% CI [CI, 0.26, 0.39]). Conclusion: Based on databases providing complete national coverage on twins with chromosomal aberrations, we found no overall difference in risk of chromosomal aberrations or T21 in twins versus singletons. Around conception twins may have an increased risk of chromosomal aberrations, but loss of especially MZ embryos could lead to similar risk among live-born twins and singletons.

Lower Marriage and Divorce Rates Among Twins Than Among Singletons in Danish Birth Cohorts 1940–1964

2011 ◽  
Vol 14 (2) ◽  
pp. 150-157 ◽  
Author(s):  
Inge Petersen ◽  
Torben Martinussen ◽  
Matthew McGue ◽  
Paul Bingley ◽  
Kaare Christensen
Keyword(s):  
Divorce Rate ◽  
Hazard Ratio ◽  
Birth Cohorts ◽  
Danish Population ◽  
Marriage Rates ◽  
Marriage And Divorce ◽  
First Marriage ◽  
Civil Status ◽  
Divorce Rates ◽  
Danish Twin

Few studies have examined differences of civil status of twins and singletons and the conclusions are contradictory. In the present study, based on a linkage between the Danish Twin Register, a random 5% sample of the total Danish population, and administrative register databases, the authors compare rates of marriage and divorce in a sample of 35,975 twins and 81,803 singletons born 1940–1964. Cox-regressions are used in order to control for potential confounders. We find that compared with singletons twins have significantly lower marriage rates: (males: 15–19 years: Hazard Ratio (HR) = 0.66 (95%CI: 0.58–0.76); 20–24 years: 0.85 (0.82–0.88); 25 years or more: 0.96 (0.93–0.98) and females: 15–19 years: 0.70 (0.67–0.75); 20–24 years: 0.83 (0.80–0.85); 25 years or more: 0.94 (0.91–0.97)). There is no difference in divorce rates for males, but a significantly lower divorce rate for female twins compared with singletons (HR=0.87, 95%CI: 0.83–0.90). These differences offset each other, thus 57% of both populations remain in their first marriage until censoring. The interpretation may be that since twins have a partner from birth, they do not have the same need for marriage as singletons but have more experience in maintaining a relationship if they do marry.

Myeloproliferative Neoplasms in Danish Twins

2018 ◽  
Vol 139 (3) ◽  
pp. 195-198 ◽  
Author(s):  
Michael Asger  Andersen ◽  
Ole Weis Bjerrum ◽  
Ajenthen Ranjan ◽  
Vibe Skov ◽  
Torben A. Kruse ◽  
...  
Keyword(s):  
Myeloproliferative Neoplasms ◽  
Case Reports ◽  
Monozygotic Twin ◽  
Dizygotic Twin ◽  
National Patient Registry ◽  
Twin Registry ◽  
Danish National Patient Registry ◽  
National Patient ◽  
Danish Twin

Objective: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown. Method: All twin pairs born in the period 1900–2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry. Results: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016). Conclusion: An estimated concordance rate of 15% (95% CI 0.059–0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

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