scholarly journals The Danish Twin Registry: An Updated Overview

2019 ◽  
Vol 22 (6) ◽  
pp. 499-507 ◽  
Author(s):  
Dorthe Almind Pedersen ◽  
Lisbeth Aagaard Larsen ◽  
Marianne Nygaard ◽  
Jonas Mengel-From ◽  
Matt McGue ◽  
...  
Keyword(s):  
Biological Samples ◽  
Twin Studies ◽  
Molecular Data ◽  
Short Description ◽  
Repeated Measurements ◽  
Birth Cohorts ◽  
Twin Registry ◽  
Wide Range ◽  
The World ◽  
Danish Twin

AbstractThe Danish Twin Registry (DTR) was established in the 1950s, when twins born from 1870 to 1910 were ascertained, and has since been extended to include twins from birth cohorts until 2009. The DTR currently comprises of more than 175,000 twins from the 140 birth cohorts. This makes the DTR the oldest nationwide twin register and among the largest in the world. The combination of data from several surveys, including biological samples and repeated measurements on the same individuals, and data from Danish national registers provides a unique resource for a wide range of twin studies. This article provides an updated overview of the data in the DTR: First, we provide a summary of the establishment of the register, the different ascertainment methods and the twins included; then follows an overview of major surveys conducted in the DTR since 1994 and a description of the DTR biobank, including a description of the molecular data created so far; finally, a short description is given of the linkage to Danish national registers at Statistics Denmark and some recent examples of studies using the various data resources in the DTR are highlighted.

scholarly journals The Danish Twin Registry in the New Millennium

2006 ◽  
Vol 9 (6) ◽  
pp. 763-771 ◽  
Author(s):  
Axel Skytthe ◽  
Kirsten Kyvik ◽  
Lise Bathum ◽  
Niels Holm ◽  
James W. Vaupel ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Normal Variation ◽  
New Developments ◽  
The Metabolic Syndrome ◽  
Twin Registry ◽  
Age Related ◽  
The World ◽  
Health Related ◽  
Danish Twin

AbstractThe Danish Twin Registry is the oldest national twin register in the world, initiated in 1954, and, by the end of 2005, contained more than 75,000 twin pairs born in the between 1870 and 2004. The Danish Twin Registry is used as a source for studies on the genetic influence on normal variation in clinical parameters associated with the metabolic syndrome and cardiovascular diseases, clinical studies of specific diseases, and aging and age-related health problems. The combination of survey data, clinical data and linkage to national health-related registers enables follow-up studies of both the general twin population and twins from clinical studies. This paper summarizes the newest extension of the register and gives examples of new developments and phenotypes studied.

The Nigerian Twin and Sibling Registry

2012 ◽  
Vol 16 (1) ◽  
pp. 282-284 ◽  
Author(s):  
Yoon-Mi Hur ◽  
Jong Woo Kim ◽  
Kee Wha Chung ◽  
Joong Sik Shin ◽  
Hoe-Uk Jeong ◽  
...  
Keyword(s):  
Cognitive Abilities ◽  
Birth Rate ◽  
Twin Studies ◽  
Recruitment Strategies ◽  
Parallel Study ◽  
Future Directions ◽  
South Korean ◽  
Twin Birth ◽  
Twin Registry ◽  
The World

Twin studies of Africans have been scarce although Africans have shown the highest twin birth rate in the world. As a parallel study of the South Korean Twin Registry, the Nigerian Twin and Sibling Registry (NTSR) was developed to understand causal influences on the development of cognitive abilities, personality, and mental health among Nigerians. Currently, 1,134 twins and 404 full- and half-siblings have been registered with NTSR. This article describes research background, goals, major recruitment strategies, measures, and future directions of the NTSR.

No Evidence of Genetic Mediation in the Association Between Birthweight and Academic Performance in 2,413 Danish Adolescent Twin Pairs

2009 ◽  
Vol 12 (6) ◽  
pp. 564-572 ◽  
Author(s):  
Inge Petersen ◽  
Vibeke Myrup Jensen ◽  
Matt McGue ◽  
Paul Bingley ◽  
Kaare Christensen
Keyword(s):  
Academic Performance ◽  
Genetic Factors ◽  
Large Population ◽  
Twin Studies ◽  
Positive Association ◽  
Population Based ◽  
Birth Cohorts ◽  
Individual Level ◽  
Shed Light ◽  
Danish Twin

AbstractEvidence of a positive association between birthweight and IQ has been established in several studies. Analyses of within twin pair differences in birthweight and IQ have been used to shed light on the basis of the association. The strength of this approach is the possibility of controlling for both unmeasured common childhood–environmental factors as well as genetic factors shared by the co-twins. Two twin studies suggest the existence of genetic mediation between birthweight and IQ, that is, common genetic factors influence both fetal growth and IQ in childhood, while two other twin studies find no evidence of such mediation. In the present study we use a large population-based national register study of 2,413 Danish twin-pairs from birth cohorts 1986–1990, of which we have zygosity information on 74%. We perform individual level as well as intra-pair analyses of birthweight and school achievements at age 16. For both sexes we observed a monotonic increase in academic performance with increasing percentiles of birthweight. However, we did not find that this association is due to genetic mediation.

scholarly journals First Steps of the Mexico Twin Registry (RGMex-MexTR) at the University of Guadalajara

2019 ◽  
Vol 22 (6) ◽  
pp. 609-610
Author(s):  
Guillermo A. Cervantes-Cardona ◽  
Tania E. Cervantes-Nápoles ◽  
Gabino Cervantes-Guevara ◽  
Olga R. Manzo-Palomera ◽  
Alejandro González-Ojeda ◽  
...  
Keyword(s):  
Social Sciences ◽  
Latin America ◽  
Twin Studies ◽  
Research Community ◽  
Short Term ◽  
Twin Research ◽  
Twin Registry ◽  
The World ◽  
The University

AbstractDespite the well-known relevance of twin studies in the medical and social sciences and the growing number of twin registries throughout the world, Latin America has not fully incorporated into the twin research community. We describe the first steps taken toward developing a twin registry in Mexico: its aim, organization, recruiting potential and main short-term objectives.

scholarly journals Biobanking in oncology and radiology

2018 ◽  
Vol 11 (4) ◽  
pp. 170-177 ◽  
Author(s):  
Pavel O. Roumiantsev ◽  
Ali M. Mudunov
Keyword(s):  
Personalized Medicine ◽  
Biological Samples ◽  
Evidence Based ◽  
Thyroid Tumors ◽  
International Evidence ◽  
Information Logistics ◽  
Wide Range ◽  
The World ◽  
Methodological Guidelines

The first biobank in Russia was created in 1998 to investigate post-Chernobyl thyroid tumors. The number of biobanks in the world is growing. Infrastructure and collaboration are improving. Ethical, legal and methodological guidelines for biobanking have been developed and are regularly reviewed. Biobanking objects are now not only biological samples of patients but also their dynamic biomedical characteristics. Comparison of genetics, proteome and tumour metabolism and in vivo radiological visualization is necessary to improve personalized diagnostics, treatment and its effectiveness. The article focuses on international evidence-based experience of sample preparation and cryopreservation of biological samples, information logistics, and integration solutions in biobanking. Guiding principles and the model of a modern biobank, integrating up-to-date technologies of digital personalized medicine and telemedicine in oncology and radiology are reported. The article may be of interest to a wide range of experts in biomedicine, especially oncologists, radiologists, pathologists, geneticists, and IT specialists.

scholarly journals The Danish Twin Registry: 127 Birth Cohorts of Twins

Twin Research ◽  
2002 ◽  
Vol 5 (5) ◽  
pp. 352-357 ◽  
Author(s):  
Axel Skytthe ◽  
Kirsten Kyvik ◽  
Niels V. Holm ◽  
James W. Vaupel ◽  
Kaare Christensen
Keyword(s):  
Birth Cohorts ◽  
Twin Registry ◽  
Danish Twin

scholarly journals The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

2015 ◽  
Vol 18 (4) ◽  
pp. 348-360 ◽  
Author(s):  
Karri Silventoinen ◽  
Aline Jelenkovic ◽  
Reijo Sund ◽  
Chika Honda ◽  
Sari Aaltonen ◽  
...  
Keyword(s):  
Large Scale ◽  
Genetic Research ◽  
Twin Studies ◽  
Repeated Measurements ◽  
Human Populations ◽  
Birth Cohorts ◽  
Related Factors ◽  
Individual Level ◽  
Heritability Estimates ◽  
New Research

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

Creative Strategy Used in Electronic Advertising

GIS Business ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. 597-606
Author(s):  
Dr. Maha Mustafa Omer Abdalaziz
Keyword(s):  
The Internet ◽  
Business Organizations ◽  
Creative Strategy ◽  
Electronic Environment ◽  
Wide Range ◽  
The World ◽  
Technological Developments ◽  
Electronic Advertising

The study aims at the technological developments that are taking place in the world and have impacted on all sectors and fields and imposed on the business organizations and commercial companies to carry out their marketing and promotional activities within the electronic environment. The most prominent of these developments is the emergence of the concept of electronic advertising which opened a wide range of companies and businessmen to advertise And to promote their products and their work easily through the Internet, which has become full of electronic advertising, and in light of that will discuss the creative strategy used in electronic advertising;

ARTISTIC ASSIMILATION OF THE WORLD IN THE ESSAY PROSE OF M. G. ATAMANOV (BASED ON THE BOOK “I AM UDMURT. WHY DOES IT HURT?”)

2020 ◽  
Vol 14 (3) ◽  
pp. 459-464
Author(s):  
Alevtina Vasilevna Kamitova ◽  
Tatyana Ivanovna Zaitseva
Keyword(s):  
Ethnic Identity ◽  
National Identity ◽  
National Culture ◽  
Native Language ◽  
Topographic Features ◽  
Wide Range ◽  
The World ◽  
The Subject ◽  
Individual Style

The paper reflects the specificity of the fundamental ideas of the artistic world of M. G. Atamanov, which includes a wide range of literary facts from the content level of the text of the works to their poetics. A particularly important role in the works of M. G. Atamanov is played by cross-cutting themes and images that reflect the author's individual style and his idea of national-ethnic identity. The subject of the research is the book of essays “Mon - Udmurt. Maly mynym vös’?” (“I am Udmurt. Why does it hurt?”), which most vividly reflected the main spiritual and artistic searches of M. G. Atamanov, associated with his ideas about the Udmurt people. The main motives and plots of the works included in the book under consideration are accumulated around the concept of “Udmurtness”. The comprehension of “Udmurtness” is modeled in his essays through specific leit themes: native language, Udmurt people, national culture, mentality, geographic and topographic features of the Udmurt people’ places of residence, the Orthodox idea. The “Udmurt theme” is recognized and comprehended by the writer through the prism of national identity.

Potential Triazole-based Molecules for the Treatment of Neglected Diseases

2019 ◽  
Vol 26 (23) ◽  
pp. 4403-4434 ◽  
Author(s):  
Susimaire Pedersoli Mantoani ◽  
Peterson de Andrade ◽  
Talita Perez Cantuaria Chierrito ◽  
Andreza Silva Figueredo ◽  
Ivone Carvalho
Keyword(s):  
Effective Treatment ◽  
Chagas Disease ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Neglected Diseases ◽  
Triazole Derivatives ◽  
Wide Range ◽  
The World ◽  
Great Relevance ◽  
The Moment

Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance in medicinal chemistry due to a wide range of biological activities. This review aims to describe some of the most relevant and recent research focused on 1,2,3- and 1,2,4-triazolebased molecules targeting four expressive NDs: Chagas disease, Malaria, Tuberculosis and Leishmaniasis.

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