Effects of Long-term Oxygen Therapy on Pulmonary Hemodynamics in COPD Patients

Long term oxygen therapy (LTOT) has been shown to improve the survival rate in Chronic Obstructive Pulmonary Disease (COPD) patients with severe resting hypoxemia by NOTT and MRC studies, published more than 25 years ago. The improved survival was found in patients who received oxygen for more than 15 hours/day. The effectiveness of LTOT has been documented only in stable COPD patients with severe chronic hypoxemia at rest (PaO255%. In fact no evidence supports the use of LTOT in COPD patients with moderate hypoxemia (55<PaO2<65 mmHg), and in those with decreased oxygen saturation (SO2<90%) during exercise or sleep. Furthermore, it is generally accepted without evidence that LTOT in clinical practice is warranted in other forms of chronic respiratory failure not due to COPD when arterial blood gas criteria match those established for COPD patients. The prescription of oxygen in these circumstances, as for unstable patients, increases the number of patients receiving supplemental oxygen and the related costs. Comorbidities are likely to affect both prognosis and health outcomes in COPD patients, but at the moment we do not know if LTOT in these patients with complex chronic diseases and mild-moderate hypoxemia could be of any use. For these reasons a critical revision of the actual guide lines indications for LTOT in order to optimise effectiveness and costs, and future research in the areas that have not previously been addressed by NOTT and MRC studies, are mandatory.

Download Full-text

Are COPD Patients with Nocturnal REM Sleep-Related Desaturations More Prone to Developing Chronic Respiratory Failure Requiring Long-Term Oxygen Therapy?

Respiration ◽

10.1159/000056313 ◽

2002 ◽

Vol 69 (2) ◽

pp. 117-122 ◽

Cited By ~ 11

Author(s):

Margherita Sergi ◽

Maurizio Rizzi ◽

Arnaldo Andreoli ◽

Marica Pecis ◽

Claudio Bruschi ◽

...

Keyword(s):

Respiratory Failure ◽

Rem Sleep ◽

Oxygen Therapy ◽

Chronic Respiratory Failure ◽

Copd Patients ◽

Long Term Oxygen Therapy

Download Full-text

Impact of long-term oxygen therapy on systemic inflammation, morphological changes of red blood cells, pulmonary hemodynamics and diaphragm function in patients with chronic obstructive pulmonary disease.

10.1183/13993003.congress-2018.pa691 ◽

2018 ◽

Author(s):

Olga Titova ◽

Natalya Kuzubova ◽

Daria Sklyarova ◽

Vladimir Volchkov

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Blood Cells ◽

Oxygen Therapy ◽

Morphological Changes ◽

Chronic Obstructive ◽

Pulmonary Hemodynamics ◽

Obstructive Pulmonary Disease ◽

Long Term Oxygen Therapy

Download Full-text

Late Breaking Abstract - Qter® and Creatine improve functional performance in COPD patients on long-term oxygen therapy

10.1183/13993003.congress-2018.pa687 ◽

2018 ◽

Author(s):

Francesca de Blasio ◽

Bartolome R. Celli ◽

Francesca Polverino ◽

Roberta Pastorelli ◽

Manuela Ferrario ◽

...

Keyword(s):

Oxygen Therapy ◽

Functional Performance ◽

Copd Patients ◽

Long Term Oxygen Therapy

Download Full-text

Effect on Mortality With the Use of Beta Blockers in COPD Patients on Long-Term Oxygen Therapy

CHEST Journal ◽

10.1016/j.chest.2017.08.844 ◽

2017 ◽

Vol 152 (4) ◽

pp. A813

Author(s):

John Matera ◽

Shad Mahmood ◽

Shashi Bellam

Keyword(s):

Oxygen Therapy ◽

Beta Blockers ◽

Copd Patients ◽

Long Term Oxygen Therapy

Download Full-text

Long-term oxygen therapy in COPD patients: population-based cohort study on mortality

International Journal of Chronic Obstructive Pulmonary Disease ◽

10.2147/copd.s154749 ◽

2018 ◽

Vol Volume 13 ◽

pp. 979-988 ◽

Cited By ~ 7

Author(s):

Nikolay Pavlov ◽

Alan Haynes ◽

Armin Stucki ◽

Peter Jüni ◽

Sebastian Robert Ott

Keyword(s):

Cohort Study ◽

Oxygen Therapy ◽

Population Based ◽

Copd Patients ◽

Long Term Oxygen Therapy

Download Full-text

Changes in Body Weight and Serum Albumin Levels in Patients Requiring Home Long-term Oxygen Therapy

Asian/Pacific Island Nursing Journal ◽

10.31372/20200504.1113 ◽

2021 ◽

Vol 5 (4) ◽

pp. 199-206

Author(s):

Naomi Kayauchi ◽

Eiji Ojima ◽

Katsunori Kagohashi ◽

Hiroaki Satoh

Keyword(s):

Heart Failure ◽

Body Weight ◽

Respiratory Failure ◽

Chronic Heart Failure ◽

Nutritional Status ◽

Serum Albumin ◽

Oxygen Therapy ◽

Copd Patients ◽

Long Term Oxygen Therapy

Purpose: To investigate the long-term changes in body weight and serum albumin levels in patients with respiratory failure, and those with chronic heart failure, who were treated with home long-term oxygen therapy (LTOT) to understand the current status and contribute to future measures. Methods: Patients with chronic obstructive pulmonary disease (COPD), those with interstitial pneumonia (IP), and those with chronic heart failure (CHF) undergoing home LTOT for 6 months or more between January 2011 and January 2019 were included in the study. Body weight and serum albumin levels were assessed at the start of home LTOT and at the end of the observation period, a minimum of 6 months after commencing home LTOT. Results: Sixty-two patients (29 COPDs, 23 IPs, and 10 CHFs) were included. In COPD patients and IP patients, body weight decreased (P = 0.0017, P = 0.0018, respectively, Wilcoxon signed-rank test). Serum albumin levels decreased in IP patients (P = 0.0185) but not in COPD patients. There was neither significant decrease in body weight nor serum albumin levels in patients with CHF. Conclusion: Chronic respiratory failure patients who have home LTOT were likely to have a decreased nutritional status. In order to provide prolonged home LTOT, medical staff need to pay close attention to the nutritional status of patients receiving home LTOT.

Download Full-text