scholarly journals Biochemical, electrolytic, and cardiovascular evaluations in cats with urethral obstruction

2021 ◽  
pp. 2002-2008
Author(s):  
Darlan Henrique Canei ◽  
Mariana Elisa Pereira ◽  
Maria Natália de Freitas ◽  
Yolanda Paim Arruda Trevisan ◽  
Carolina Zorzo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Serum Biochemistry ◽  
Cardiac Troponin I ◽  
Urethral Obstruction ◽  
Cardiac Biomarkers ◽  
Electrolyte Disorders ◽  
Blood Gas Monitoring ◽  
Electrocardiographic Abnormalities

Background and Aim: Urethral obstruction (UO) is a common condition in feline medicine. Severe acid-base and electrolyte disorders promote relevant electrocardiographic changes in these animals. Cardiac biomarkers such as cardiac troponin I have been shown to be useful in identifying cats with myocardial disease, but it has not been investigated whether UO leads to myocardial damages. This study aimed to evaluate biochemical changes, electrocardiographic findings, troponin I measurements, and electrolyte disturbances for 7 days in cats with UO. Materials and Methods: This follow-up prospective study included 33 cats diagnosed with UO for 7 days. For all cats, clinical examination, serum biochemistry, electrolyte analyses, blood pressure, and electrocardiography were performed. Cardiac troponin I was measured in the serum in 16 cats at 3 different times. Results: The mean age of the feline population was 1.83±1.58 years (mean±standard deviation). Creatinine, urea, blood urea nitrogen, glucose, phosphorus, base excess, bicarbonate, and serum potassium decreased significantly (p≤0.05), while ionic calcium and blood pH increased significantly (p≤0.05) at different times. Electrocardiographic abnormalities were observed in 21/33 (63.63%) of the felines on admission day. The electrocardiographic abnormalities were no longer observed on the subsequent days. Only one feline showed changes in troponin I cardiac concentrations. Conclusion: This study suggests the sum and severity of electrolyte abnormalities aggravate the clinical and cardiovascular status of these patients. However, cTnI, blood pressure, and heart rate within the reference range do not exclude the presence of major cardiovascular and metabolic abnormalities. The hyperglycemia in felines with UO appears to be associated with decreased renal clearance, which may reflect the severity of hyperkalemia and azotemia. The metabolic and cardiovascular changes of these felines are minimized by the establishment of appropriate intensive care; however, cardiac and blood gas monitoring is essential to assess the severity of the disease.

scholarly journals Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study

2019 ◽  
Vol 65 (7) ◽  
pp. 871-881 ◽  
Author(s):  
Magnus N Lyngbakken ◽  
Helge Røsjø ◽  
Oddgeir L Holmen ◽  
Håvard Dalen ◽  
Kristian Hveem ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
General Population ◽  
Cardiac Troponin ◽  
Cardiovascular Events ◽  
Troponin I ◽  
Temporal Changes ◽  
Relative Increase ◽  
Cardiac Troponin I ◽  
Recent Measurement

Abstract BACKGROUND Cardiac troponins are associated with cardiovascular risk in the general population, but whether temporal changes in cardiac troponin I provide independent prognostic information remains uncertain. Using a large community-based cohort with follow-up close to the present day, we aimed to investigate the associations between temporal changes in cardiac troponin and cardiovascular events. METHODS We measured cardiac troponin I with a high-sensitivity assay (hs-cTnI) in 4805 participants attending both the second (HUNT 2, 1995–97) and third wave (HUNT 3, 2006–2008) of the prospective observational Nord-Trøndelag Health (HUNT) Study. We constructed statistical models with both relative and absolute changes of hs-cTnI from HUNT 2 to HUNT 3. A composite end point of cardiovascular death or first admission for myocardial infarction or heart failure was generated. RESULTS Participants with relative decrease in hs-cTnI were more frequently younger and female and had lower blood pressure and body mass index. Participants with relative increase in hs-cTnI more frequently were older and male, with higher systolic blood pressure. The adjusted hazard ratio (HR) for relative increase in hs-cTnI was 1.68 (95% CI, 1.16–2.42) and the adjusted HR for relative decrease was 1.19 (95% CI, 0.84–1.68). Absolute increases in hs-cTnI exhibited similar prognostic properties as relative increases in hs-cTnI. The most recent measurement of hs-cTnI outperformed the change variables in discrimination and reclassification models. CONCLUSIONS Both relative and absolute increases in hs-cTnI are independently associated with cardiovascular risk. For refinement of risk prediction models, the most recent measurement of hs-cTnI should be preferred in clinical practice.

scholarly journals Relationship Between High-Sensitivity Cardiac Troponin I and Blood Pressure Among Young and Healthy Adults

2014 ◽  
Vol 28 (6) ◽  
pp. 789-796 ◽  
Author(s):  
Stefanie Aeschbacher ◽  
Tobias Schoen ◽  
Matthias Bossard ◽  
Stephanie van der Lely ◽  
Kathrin Glättli ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
High Sensitivity ◽  
Cardiac Troponin I ◽  
Healthy Adults

scholarly journals Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease

2020 ◽  
Vol 13 (5) ◽  
pp. 890-895
Author(s):  
Mahmoud Aly ◽  
Mohamed Nayel ◽  
Akram Salama ◽  
Emad Ghazy ◽  
Ibrahim Elshahawy
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Foot And Mouth Disease ◽  
Cardiac Troponin I ◽  
Mouth Disease ◽  
Cardiac Biomarkers ◽  
Poor Survival ◽  
Buffalo Calves ◽  
Foot And Mouth ◽  
Egyptian Buffalo

Background and Aim: Foot-and-mouth disease (FMD) causes huge economic losses in Egypt due to reductions in the production of red meat, milk, and milk by-products and can also lead to myocarditis in young animals. The aim of our study was to evaluate cardiac biomarkers, in particular cardiac troponin I (cTnI), and to reveal the relations of cardiac biomarkers with poor survival in FMD-infected Egyptian buffalo calves. Materials and Methods: Forty-two Egyptian buffalo calves were included in this study. The calves were divided into 12 apparently healthy control calves and 30 calves clinically diagnosed with FMD during a disease outbreak in Menofia and Behera Governorates, Egypt. The diseased calves were divided, according to age, into 13 calves <3 months old and 17 calves between 3 and 6 months old. The animals were examined clinically and subjected to analysis of cardiac biomarkers. Results: Biochemical analysis revealed significant elevations of cardiac biomarkers, especially creatine kinase myocardial band (CK-MB), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) in FMD-infected calves in comparison with control calves. There was a significant association between cTnI and poor survival in infected calves. Conclusion: Cardiac biomarkers could be used as a rapid method for diagnosis of myocarditis induced by FMD in Egyptian buffalo calves. In addition, cTnI is a very sensitive and accurate tool for determining myocardial cell damage in the earlier stages of the disease and a good predictor of poor survival in calves.

scholarly journals Comparison of the Effects of Ketamine-Dexmedetomidine and Sevoflurane-Sufentanil Anesthesia on Cardiac Biomarkers After Cardiac Surgery: An Observational Study

2012 ◽  
pp. 63-72 ◽  
Author(s):  
H. ŘÍHA ◽  
T. KOTULÁK ◽  
A. BŘEZINA ◽  
L. HESS ◽  
P. KRAMÁŘ ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Observational Study ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Ischemia Reperfusion ◽  
Artery Bypass ◽  
Experimental Studies ◽  
Cardiac Troponin I ◽  
Cardiac Biomarkers ◽  
Cardioprotective Effects

Inhalational anesthetics have demonstrated cardioprotective effects against myocardial ischemia-reperfusion injury. Clinical studies in cardiac surgery have supported these findings, although not with the consistency demonstrated in experimental studies. Recent investigations have questioned the advantages of inhalational over intravenous anesthetics with respect to cardiac protection. Ketamine has been shown to be comparable with sufentanil, and has even demonstrated anti-inflammatory properties. Dexmedetomidine has been established as a sedative/anesthetic drug with analgesic properties, and has also demonstrated myocardial protective effects. In this retrospective observational study, the influence of ketamine-dexmedetomidine-based anesthesia (KET-DEX group; n=17) on the release of cardiac biomarkers was compared with that of sevoflurane-sufentanil-based anesthesia (SEVO group; n=21) in patients undergoing elective coronary artery bypass grafting. Compared with the SEVO group, the KET-DEX group exhibited significantly reduced cardiac troponin I (2.22±1.73 vs. 3.63±2.37 µg/l; P=0.02) and myocardial fraction of creatine kinase (CK-MB) levels (12.4±10.4 vs. 20.3±11.2 µg/l; P=0.01) on the morning of the first postoperative day. Furthermore, cardiac troponin I release, evaluated as the area under the curve, was significantly reduced in the KET-DEX group (32.1±20.1 vs. 50.6±23.2; P=0.01). These results demonstrate the cardioprotective effects of ketamine-dexmedetomidine anesthesia compared with those of sevoflurane-sufentanil anesthesia.

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