scholarly journals Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease

2020 ◽  
Vol 13 (5) ◽  
pp. 890-895
Author(s):  
Mahmoud Aly ◽  
Mohamed Nayel ◽  
Akram Salama ◽  
Emad Ghazy ◽  
Ibrahim Elshahawy
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Foot And Mouth Disease ◽  
Cardiac Troponin I ◽  
Mouth Disease ◽  
Cardiac Biomarkers ◽  
Poor Survival ◽  
Buffalo Calves ◽  
Foot And Mouth ◽  
Egyptian Buffalo

Background and Aim: Foot-and-mouth disease (FMD) causes huge economic losses in Egypt due to reductions in the production of red meat, milk, and milk by-products and can also lead to myocarditis in young animals. The aim of our study was to evaluate cardiac biomarkers, in particular cardiac troponin I (cTnI), and to reveal the relations of cardiac biomarkers with poor survival in FMD-infected Egyptian buffalo calves. Materials and Methods: Forty-two Egyptian buffalo calves were included in this study. The calves were divided into 12 apparently healthy control calves and 30 calves clinically diagnosed with FMD during a disease outbreak in Menofia and Behera Governorates, Egypt. The diseased calves were divided, according to age, into 13 calves <3 months old and 17 calves between 3 and 6 months old. The animals were examined clinically and subjected to analysis of cardiac biomarkers. Results: Biochemical analysis revealed significant elevations of cardiac biomarkers, especially creatine kinase myocardial band (CK-MB), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) in FMD-infected calves in comparison with control calves. There was a significant association between cTnI and poor survival in infected calves. Conclusion: Cardiac biomarkers could be used as a rapid method for diagnosis of myocarditis induced by FMD in Egyptian buffalo calves. In addition, cTnI is a very sensitive and accurate tool for determining myocardial cell damage in the earlier stages of the disease and a good predictor of poor survival in calves.

scholarly journals Determination of Cardiac Troponin I in the Blood and Heart of Calves with Foot-and-Mouth Disease

2008 ◽  
Vol 20 (5) ◽  
pp. 598-605 ◽  
Author(s):  
Recai Tunca ◽  
Mahmut Sozmen ◽  
Hidayet Erdogan ◽  
Mehmet Citil ◽  
Erdogan Uzlu ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Foot And Mouth Disease ◽  
Cardiac Troponin I ◽  
Mouth Disease ◽  
Foot And Mouth

scholarly journals Clinical and histopathological studies on neurodegeneration and dysautonomia in buffalo calves during foot-and-mouth disease outbreaks in Egypt

2021 ◽  
pp. 1622-1630
Author(s):  
Yasmin Bayoumi ◽  
Nader Sobhy ◽  
Abdelkarem Morsi ◽  
Wafaa El-Neshwey ◽  
Nora El-Seddawy ◽  
...  
Keyword(s):  
Nervous Tissue ◽  
Neuronal Degeneration ◽  
Histopathological Examination ◽  
Disease Outbreaks ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Buffalo Calves ◽  
Serotype O ◽  
Foot And Mouth ◽  
Malignant Group

Background and Aim: Signs of dysautonomia were frequently observed in calves that died during foot-and-mouth disease (FMD) virus (FMDV) outbreaks in Egypt from 2015 to 2018. This study aimed to describe the clinical and histopathological features of the central nervous system in malignant cases of FMD and excluding possible concurrent bacterial, and bovine herpes virus 4 (BHV4) infections or both. Materials and Methods: In this study, 335 FMDV-infected buffalo calves aged 1-22 months were clinically examined and followed until recovery or death. Of the 335 calves, 134 died (malignant group) and 201 recovered after exhibiting classic symptoms of FMD (recover group). The calves were subjected to clinical examination. For the malignant group, several laboratory trials were conducted to assess the possible cause/s of dysautonomia-related viral, bacterial, or concurrent infections. Koch's postulates and polymerase chain reaction were employed. Postmortem and histopathological examinations of nervous tissue were performed. Results: In the malignant group, signs of dysautonomia were observed before death, including partial or complete gut dysfunction, loss of anal sphincter tone, rapid breathing sounds, fluctuating body temperature, and cardiac arrhythmias. In the malignant group, histopathological examination of the spinal cord, pons, medulla oblongata, hypothalamus, cerebellum, and cerebrum revealed demyelination, neuronal degeneration, and focal areas of malacia and gliosis. The nervous tissue and heart samples from malignant cases were positive for serotype O FMDV. Conclusion: Findings revealed in this study support the existence of neurodegeneration induced by FMDV infection in buffalo calves.

Characterization of arrhythmias, evaluation of cardiac biomarkers and their association with survival in calves suffering from foot-and-mouth disease

2021 ◽  
Author(s):  
Priyanka Mahadappa ◽  
Karunanithy Mahendran ◽  
Randolph L. Winter ◽  
Vijayapillai Umapathi ◽  
Narayanan Krishnaswamy ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Cardiac Biomarkers ◽  
Foot And Mouth

scholarly journals Biochemical, electrolytic, and cardiovascular evaluations in cats with urethral obstruction

2021 ◽  
pp. 2002-2008
Author(s):  
Darlan Henrique Canei ◽  
Mariana Elisa Pereira ◽  
Maria Natália de Freitas ◽  
Yolanda Paim Arruda Trevisan ◽  
Carolina Zorzo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Serum Biochemistry ◽  
Cardiac Troponin I ◽  
Urethral Obstruction ◽  
Cardiac Biomarkers ◽  
Electrolyte Disorders ◽  
Blood Gas Monitoring ◽  
Electrocardiographic Abnormalities

Background and Aim: Urethral obstruction (UO) is a common condition in feline medicine. Severe acid-base and electrolyte disorders promote relevant electrocardiographic changes in these animals. Cardiac biomarkers such as cardiac troponin I have been shown to be useful in identifying cats with myocardial disease, but it has not been investigated whether UO leads to myocardial damages. This study aimed to evaluate biochemical changes, electrocardiographic findings, troponin I measurements, and electrolyte disturbances for 7 days in cats with UO. Materials and Methods: This follow-up prospective study included 33 cats diagnosed with UO for 7 days. For all cats, clinical examination, serum biochemistry, electrolyte analyses, blood pressure, and electrocardiography were performed. Cardiac troponin I was measured in the serum in 16 cats at 3 different times. Results: The mean age of the feline population was 1.83±1.58 years (mean±standard deviation). Creatinine, urea, blood urea nitrogen, glucose, phosphorus, base excess, bicarbonate, and serum potassium decreased significantly (p≤0.05), while ionic calcium and blood pH increased significantly (p≤0.05) at different times. Electrocardiographic abnormalities were observed in 21/33 (63.63%) of the felines on admission day. The electrocardiographic abnormalities were no longer observed on the subsequent days. Only one feline showed changes in troponin I cardiac concentrations. Conclusion: This study suggests the sum and severity of electrolyte abnormalities aggravate the clinical and cardiovascular status of these patients. However, cTnI, blood pressure, and heart rate within the reference range do not exclude the presence of major cardiovascular and metabolic abnormalities. The hyperglycemia in felines with UO appears to be associated with decreased renal clearance, which may reflect the severity of hyperkalemia and azotemia. The metabolic and cardiovascular changes of these felines are minimized by the establishment of appropriate intensive care; however, cardiac and blood gas monitoring is essential to assess the severity of the disease.

scholarly journals Comparison of the Effects of Ketamine-Dexmedetomidine and Sevoflurane-Sufentanil Anesthesia on Cardiac Biomarkers After Cardiac Surgery: An Observational Study

2012 ◽  
pp. 63-72 ◽  
Author(s):  
H. ŘÍHA ◽  
T. KOTULÁK ◽  
A. BŘEZINA ◽  
L. HESS ◽  
P. KRAMÁŘ ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Observational Study ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Ischemia Reperfusion ◽  
Artery Bypass ◽  
Experimental Studies ◽  
Cardiac Troponin I ◽  
Cardiac Biomarkers ◽  
Cardioprotective Effects

Inhalational anesthetics have demonstrated cardioprotective effects against myocardial ischemia-reperfusion injury. Clinical studies in cardiac surgery have supported these findings, although not with the consistency demonstrated in experimental studies. Recent investigations have questioned the advantages of inhalational over intravenous anesthetics with respect to cardiac protection. Ketamine has been shown to be comparable with sufentanil, and has even demonstrated anti-inflammatory properties. Dexmedetomidine has been established as a sedative/anesthetic drug with analgesic properties, and has also demonstrated myocardial protective effects. In this retrospective observational study, the influence of ketamine-dexmedetomidine-based anesthesia (KET-DEX group; n=17) on the release of cardiac biomarkers was compared with that of sevoflurane-sufentanil-based anesthesia (SEVO group; n=21) in patients undergoing elective coronary artery bypass grafting. Compared with the SEVO group, the KET-DEX group exhibited significantly reduced cardiac troponin I (2.22±1.73 vs. 3.63±2.37 µg/l; P=0.02) and myocardial fraction of creatine kinase (CK-MB) levels (12.4±10.4 vs. 20.3±11.2 µg/l; P=0.01) on the morning of the first postoperative day. Furthermore, cardiac troponin I release, evaluated as the area under the curve, was significantly reduced in the KET-DEX group (32.1±20.1 vs. 50.6±23.2; P=0.01). These results demonstrate the cardioprotective effects of ketamine-dexmedetomidine anesthesia compared with those of sevoflurane-sufentanil anesthesia.

scholarly journals Antibody Response of Buffalo Calves to Different Levels of Foot and Mouth Disease Virus Immunogen

2021 ◽  
pp. 466-471
Author(s):  
Qaiser Akram ◽  
Shahid Hussain Farooqi ◽  
Hafiz Muhammad Rizwan ◽  
Beenish Zahid ◽  
Muhammad Ahsan Naeem ◽  
...  
Keyword(s):  
Antibody Response ◽  
Antibody Titer ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Buffalo Calves ◽  
Fmd Virus ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Different Levels

Antibody response of buffalo calves to different levels of Foot and Mouth Disease (FMD) virus immunogen was investigated. Vaccine containing 106.2 units of immunogen/TCID50 of FMD virus (O, A and Asia-1) serotypes induced log2 (1.3± 0.4) units of anti-FMD O Complement Fixing Geometric Mean antibody (FMD O CFT-CGM) titer, log2 (1.4±0.3) units of anti-FMD A CFT-CGM titer and log2 (2.0±0.7) units of anti-FMD Asia-1 CFT-CGM titer. The vaccine containing 2x106.2 units of immunogen of each of the virus serotypes induced log2 (2.2±0.2) units of anti- FMD O CFT-CGM titer, log2 (2.1±0.25) units of anti- FMD A CFT-CGM titer and log2 (3.4±0.8) units of anti-FMD Asia-1 CFT-CGM titer. The vaccine containing 3x106.2 units of TCID50 of each of the virus serotypes induced log2 (5.3 ± 2.0) units of anti-FMD O CFT-CGM titer, log2 (4.6±1.9) units of anti-FMD A CFT-CGM titer and log2 (5.0±2.2) units of anti- FMD Asia-1 CFT-CGM titer. Moreover, buffalo calves (n=3) which were primed and boosted with 60 days interval using vaccine containing 2x106.2 units of immunogen of each of the virus serotype, showed log25.0 and log26.3 units of anti FMD O CFT-GMT antibody titer, log24.6 and log26.0 units of anti FMD A CFT GMT antibody titer, log25.6 and log26.0 units of anti FMD Asia-1 CFT GMT antibody titer, on 30 and 120 days post boosting. Antibody response of buffalo calves was directly proportional to amount of FMD virus immunogen serotypes in the vaccine. 

scholarly journals Management of Severe Hand, Foot and Mouth Disease in Xiangyang, China during 2008-2013

2019 ◽  
Author(s):  
Jian Liu ◽  
Jing Qi ◽  
Fei Zhan ◽  
Rong Jiao
Keyword(s):  
Troponin I ◽  
Early Stage ◽  
Statistical Significance ◽  
Foot And Mouth Disease ◽  
Binary Logistic Regression ◽  
Mouth Disease ◽  
Stage Iii ◽  
Predictors Of Outcome ◽  
Foot And Mouth ◽  
Administrative Experience

Abstract Background Therapeutic strategies of severe hand, foot and mouth disease (HFMD) are inconsequent or deficient in evidence by now. Methods We have retrospectively analyzed HFMD outbreaks in Xiangyang from June 2008 to December 2013. All severe cases were enrolled to analyze the risk factors causing mortality and to compare the efficiency and outcome of some therapies by binary logistic regression. Results The HFMD involved 637 (1.26%) severe cases and 38 were fatal (0.75‰). Analysis indicate that age (<3y), EV71 (+), autonomic nervous system (ANS) dysregulation, pulmonary edema/haemorrhage, CRP (>40mg/L) and cardiac troponin I (cTnI) (>0.04ng/mL) are significant predictors of outcome for severe HFMD (all P < 0.05). IVIG and mechanic ventilation can significantly improve outcome of HFMD at early stage III (both P < 0.05) with odds ratios of 0.24 (95% CI: 0.10-0.57) and 0.01 (95% CI: 0.00-0.10) respectively. Methylprednisolone and milrinone administered at any stage did not make any significant differences on mortality (all P > 0.05). All therapies had no statistical significance on outcome at stage I and II (all P > 0.05). Conclusions Exactly recognition of the sever HFMD cases in early stage III and timely IVIG and mechanic ventilation application can significantly decrease mortality. Mechanic ventilation training program, and dispatching experts to county-level or district hospital when there are severe HFMD cases who lost transfer opportunity are two key successful administrative experience.

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