Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water

The antimicrobial and cariostatic activities of the dihydrochloride and dihydrofluoride salts of alexidine (1, 6-bis-[2-ethylhexylbiguanido]hexane) were compared to those of chlorhexidine acetate and sodium fluoride in rats implanted orally with Streptococcus mutans 6715 and fed a cariogenic diet. Experimental caries was significantly reduced by the continuous administration of low concentrations of biguanides via the drinking water, but this was accompanied by increased staining of the molars. Very high biguanide concentrations, applied infrequently, directly to the molars, effectively reduced caries and resulted in less staining. A combination of alexidine dihydrochloride and sodium fluoride offered no advantage over either drug alone. Alexidine salts prevented the progressive increase in implanted S. mutans, whereas chlorhexidine acetate practically eliminated the microorganism from the oral cavity. Sodium fluoride had no effect on the implanted flora. It was concluded that alexidine salts are comparable in cariostatic activity to chlorhexidine. The tooth staining accompanying the use of bisbiguanides can be reduced by adjusting the concentration of the drug and its frequency of application.

Download Full-text

Developmental Toxicity Evaluation of Sodium Fluoride Administered to Rats and Rabbits in Drinking Water

Fundamental and Applied Toxicology ◽

10.1006/faat.1996.0053 ◽

1996 ◽

Vol 30 (2) ◽

pp. 162-177 ◽

Cited By ~ 27

Author(s):

J Heindel

Keyword(s):

Drinking Water ◽

Sodium Fluoride ◽

Developmental Toxicity ◽

Toxicity Evaluation

Download Full-text

Evaluation of Antioxidant System in Kidney of Rats Treated with Different Concentrations of Sodium Fluoride in Drinking Water for Twenty Days

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2014.10.267 ◽

2014 ◽

Vol 76 ◽

pp. S100-S101

Author(s):

Flavia G. Iano ◽

Maria C.F. Ferreira ◽

Rodrigo C. Oliveira ◽

Valdecir F. Ximenes ◽

Marília A.R. Buzalaf

Keyword(s):

Drinking Water ◽

Antioxidant System ◽

Sodium Fluoride

Download Full-text

Developmental Toxicity Evaluation of Sodium Fluoride Administered to Rats and Rabbits in Drinking Water

Toxicological Sciences ◽

10.1093/toxsci/30.2.162 ◽

1996 ◽

Vol 30 (2) ◽

pp. 162-177 ◽

Cited By ~ 1

Author(s):

JERROLD J. HEINDEL ◽

HUDSON K. BATES ◽

CATHERINE J. PRICE ◽

MELISSA C. MARR ◽

CHRISTINA B. MYERS ◽

...

Keyword(s):

Drinking Water ◽

Sodium Fluoride ◽

Developmental Toxicity ◽

Toxicity Evaluation

Download Full-text

Effect of drinking water fluoridation on the prevalence of otosclerosis

The Journal of Laryngology & Otology ◽

10.1017/s0022215100136345 ◽

1997 ◽

Vol 111 (1) ◽

pp. 20-22 ◽

Cited By ~ 13

Author(s):

Eero Vartiainen ◽

Terttu Vartiainen

Keyword(s):

Drinking Water ◽

Sodium Fluoride ◽

Natural Waters ◽

Chart Review ◽

Tap Water ◽

Retrospective Chart Review ◽

Fluoride Content ◽

Age Group ◽

Water Fluoridation ◽

Residential History

AbstractThe effect of drinking water fluoridation on the prevalence of clinical otoscierosis was investigated in an area where the natural waters have a very low fluoride content. The methods included a retrospective chart review and a residential history questionnaire. Only subjects born between 1948 and 1962 were included. In this age group, the prevalence of clinical otosclerosis was found to be 0.35 per cent of persons exposed to fluoridated tap water and 0.32 per cent of those consuming fluoride-poor water. It seems that a sodium fluoride intake of 1 to 3 mg daily cannot prevent the development of clinical otosclerosis in a lowfluoride area.

Download Full-text