scholarly journals EXPOSURE TO SODIUM FLUORIDE VIA DRINKING WATER CAUSE CYTOTOXICITY AND OXIDATIVE DAMAGE IN LEYDIG CELLS

2017 ◽  
Author(s):  
Yasemin Aydin
Keyword(s):  
Drinking Water ◽  
Oxidative Damage ◽  
Sodium Fluoride ◽  
Leydig Cells

l-arginine protects against oxidative damage induced by T-2 toxin in mouse Leydig cells

2018 ◽  
Vol 32 (10) ◽  
pp. e22209 ◽  
Author(s):  
Jian Ying Yang ◽  
Yong Fa Zhang ◽  
Yuan Xiao Li ◽  
Xiang Ping Meng ◽  
Jian Feng Bao
Keyword(s):  
Oxidative Damage ◽  
Leydig Cells

Altered sperm chromatin structure in mice exposed to sodium fluoride through drinking water

2012 ◽  
Vol 29 (6) ◽  
pp. 690-696 ◽  
Author(s):  
Zilong Sun ◽  
Ruiyan Niu ◽  
Bin Wang ◽  
Jundong Wang
Keyword(s):  
Drinking Water ◽  
Sodium Fluoride ◽  
Chromatin Structure ◽  
Sperm Chromatin

Reduction of hamster periodontal disease by sodium fluoride and sodium monofluorophosphate in drinking water

1957 ◽  
Vol 55 (5) ◽  
pp. 617-619 ◽  
Author(s):  
Emmett R. Costich ◽  
John W. Hein ◽  
Harold C. Hodge ◽  
Kanwar L. Shourie
Keyword(s):  
Drinking Water ◽  
Periodontal Disease ◽  
Sodium Fluoride

scholarly journals Protective Effect of PPARγAgonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Yousef Baghcheghi ◽  
Farimah Beheshti ◽  
Hossein Salmani ◽  
Mohammad Soukhtanloo ◽  
Mahmoud Hosseini
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Drinking Water ◽  
Oxidative Damage ◽  
Peroxisome Proliferator ◽  
Protective Effects ◽  
Peroxisome Proliferator Activated Receptor ◽  
Group I ◽  
Biochemical Measurements ◽  
Thiol Content

The aim of the current study was to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARγ) agonists on cerebellar tissues oxidative damage in hypothyroid rats. The animals included seven groups: group I (control), the animals received drinking water; group II, the animals received 0.05% propylthiouracil (PTU) in drinking water; besides PTU, the animals in groups III, IV, V, VI, and VII, were injected with 20 mg/kg vitamin E (Vit E), 10 or 20 mg/kg pioglitazone, and 2 or 4 mg/kg rosiglitazone, respectively. The animals were deeply anesthetized and the cerebellar tissues were removed for biochemical measurements. PTU administration reduced thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the cerebellar tissues while increasing malondialdehyde (MDA) and nitric oxide (NO) metabolites. Vit E, pioglitazone, and rosiglitazone increased thiol, SOD, and CAT in the cerebellar tissues while reducing MDA and NO metabolites. The results of present study showed that, similar to Vit E, both rosiglitazone and pioglitazone as PPARγagonists exerted protective effects against cerebellar tissues oxidative damage in hypothyroid rats.

Cariostatic Activity of (1,6-Bis-[2-Ethylhexylbiguanido]-Hexane) in Conventional Rats

1979 ◽  
Vol 58 (4) ◽  
pp. 1405-1412 ◽  
Author(s):  
Stephen N. Curtis ◽  
Claire L. Dooley
Keyword(s):  
Drinking Water ◽  
Oral Cavity ◽  
Streptococcus Mutans ◽  
Sodium Fluoride ◽  
Progressive Increase ◽  
Continuous Administration ◽  
Low Concentrations ◽  
Very High

The antimicrobial and cariostatic activities of the dihydrochloride and dihydrofluoride salts of alexidine (1, 6-bis-[2-ethylhexylbiguanido]hexane) were compared to those of chlorhexidine acetate and sodium fluoride in rats implanted orally with Streptococcus mutans 6715 and fed a cariogenic diet. Experimental caries was significantly reduced by the continuous administration of low concentrations of biguanides via the drinking water, but this was accompanied by increased staining of the molars. Very high biguanide concentrations, applied infrequently, directly to the molars, effectively reduced caries and resulted in less staining. A combination of alexidine dihydrochloride and sodium fluoride offered no advantage over either drug alone. Alexidine salts prevented the progressive increase in implanted S. mutans, whereas chlorhexidine acetate practically eliminated the microorganism from the oral cavity. Sodium fluoride had no effect on the implanted flora. It was concluded that alexidine salts are comparable in cariostatic activity to chlorhexidine. The tooth staining accompanying the use of bisbiguanides can be reduced by adjusting the concentration of the drug and its frequency of application.

scholarly journals Curcumin Reduce Sodium Fluoride-Induced Oxidative Stress in Rat Brain

2018 ◽  
Vol 15 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Nagapuri Kiran Kumar ◽  
Mesram Nageshwar ◽  
Karnati Pratap Reddy
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Oral Administration ◽  
Rat Brain ◽  
Sodium Fluoride ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
The Brain

This study reports the ameliorative role of curcumin against sodium fluoride (NaF) induced oxidative stress in the brain of rats. The rats were divided into control, NaF (20 mg/kg), NaF+Curcumin (20mg/kg) and Curcumin (20mg/kg) groups respectively and treated at everyday interval for 60 consecutive days. Oxidative stress markers in the brain were measured at 60th day. NaF treatment significantly increased LPO content, but decreased the level of GSH and activities of SOD, GPx, and CAT the brain of rats in comparison to the control rats. Oral administration of curcumin to fluoride exposed rats significantly reversed the content of lipid peroxidation, as well as enhanced the level of GSH and SOD, GPx and CAT activities to normal compared to NaF exposed rats. Thus, curcumin showed the potential to prevent sodium fluoride induced oxidative damage in the brain of rats and curcumin may be useful agents against neurodegeneration in the brain.

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