scholarly journals The Incidence and Characteristic of Acute Kidney Injury as A Complication of Severe Burn Injury in Patients Receiving Fluid Resuscitation

2013 ◽  
Vol 2 (2) ◽  
pp. 101-107
Author(s):  
Johannes Albert Biben

Background: Acute kidney injury is important factor that can increase mortality in patient with severe burn injury. Knowledge about incidence and characteristic of acute kidney injury among severe burned patients will help medical practitioner to establish appropriate medical decision and health care protocol. Method: PubMed, Cochrane Library, and GoogleTM search yielded 12 articles. The articles were screened by inclusion criteria, exclusion criteria, and full text reading. Five remaining articles appraised in regard of validity, importance, and applicability. Result: Incidence of acute kidney injury among severely burned patients varies from 24.4% to 53.3%. According to the study with best level of evidence, a systematic review, the incidence of AKI is 28.8% (95% CI 26.8%-30.7%). AKI can occur early or late, and may progress. Progressive AKI has highest mortality rate. Conclusion: AKI is common complication among patients with severe burn injury. Approximately one- third to half of patients with severe burn injury will develop AKI in the course of the disease. Early clinical assessment and re-evaluation are important in severe burn injury management.

Author(s):  
Nele Brusselaers ◽  
Eric A. J. Hoste

Acute kidney injury (AKI) occurs in approximately one-quarter of all patients with severe burn injury (as defined by the RIFLE consensus classification), and approximately 3% of paediatric burn patients. Overall, a three- to six-fold higher mortality for burn patients with AKI is observed, depending on the applied definition. When AKI is defined by the sensitive RIFLE classification, median mortality of AKI is approximately 35%. This chapter describes the general pathophysiology of AKI in burns, particularly the severe form of burn shock, and discusses in addition the roles of intra-abdominal hypertension, rhabdomyolysis, and the potentially negative impact of povidone-iodine burn dressing. Finally the definitions used in burn pathology, the prevention of AKI with a discussion of the fluid therapy in burned patients, and the role of renal replacement therapy in these patients is discussed.


2017 ◽  
Vol 5 ◽  
Author(s):  
Beiming Shou ◽  
Junqiang Li ◽  
Chenqi Tang ◽  
Qian Tan ◽  
Dongfeng Zheng ◽  
...  

Abstract Background Changes in platelet concentration are common in severe burn patients. Platelets play a key role in the course of disease. This study aims to explore the significance of platelet concentration during the course of the disease in victims of a mass burn casualty. Methods A total of 180 patients were involved in the “8.2” Kunshan explosion accident in China. The examined data included age, gender, total burn area (% TBSA), third-degree burn area (% TBSA), and platelet concentration within the first 5 days after the burn injury. The patients were divided into two groups according to four indicators (resuscitation, acute respiratory distress syndrome, acute kidney injury, septic shock). We collected several types of data for the patients and divided the patients into a complication group and non-complication group according to the diagnostic criteria. We analyzed the platelet concentration of the two groups using t tests to determine whether significant differences were present. P values < 0.05 were considered statistically significant. Results The group with successful resuscitation had higher platelet concentration than the failure group on day 3 and day 5. The patients who suffered from acute kidney injury (AKI) and septic shock had a lower platelet concentration than non-sufferers on day 3 and day 5. Conclusions The platelet concentration of burn patients can dynamically reflect the pathophysiological changes of the body. It can be used as an early objective indicator of prognosis in mass burn casualty cases.


Author(s):  
Wen‐Yuan Chang ◽  
Hung‐Hui Liu ◽  
Dun‐Wei Huang ◽  
Yu‐yu Chou ◽  
Kuang‐Ling Ou ◽  
...  

2011 ◽  
Vol 32 (2) ◽  
pp. 309-316 ◽  
Author(s):  
Steven Alexander Kahn ◽  
Ryan J. Beers ◽  
Christopher W. Lentz

2010 ◽  
Vol 68 (3) ◽  
pp. E77-E79 ◽  
Author(s):  
Shoji Yokobori ◽  
Masato Miyauchi ◽  
Shigeyoshi Eura ◽  
Takeshi Uchikawa ◽  
Tomohiko Masuno ◽  
...  

1992 ◽  
Vol 13 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Jane Shelby ◽  
John Sullivan ◽  
Marilyn Groussman ◽  
Robert Gray ◽  
Jeffrey Saffle

Shock ◽  
2012 ◽  
Vol 38 (3) ◽  
pp. 294-300 ◽  
Author(s):  
Nicole E. Lopez ◽  
Michael Krzyzaniak ◽  
Todd W. Costantini ◽  
Antonio De Maio ◽  
Andrew Baird ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document