scholarly journals The role of the selective CRF receptor agonists and antagonists in nicotine addiction

2019 ◽  
Author(s):  
András Buzás
Keyword(s):  
Nicotine Addiction ◽  
Receptor Agonists ◽  
Receptor Agonists And Antagonists

Role of serotonergic neurons in the maintenance of the 10-Hz rhythm in sympathetic nerve discharge

1996 ◽  
Vol 270 (1) ◽  
pp. R174-R181 ◽  
Author(s):  
H. S. Orer ◽  
M. E. Clement ◽  
S. M. Barman ◽  
S. Zhong ◽  
G. L. Gebber ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Peak Frequency ◽  
Inhibitory Effects ◽  
Receptor Agonists ◽  
Naturally Occurring ◽  
Medullary Raphe ◽  
Receptor Agonists And Antagonists ◽  
Raphe Neurons ◽  
Nerve Discharge

We studied the effects of serotonin (5-HT)-receptor agonists and antagonists on the naturally occurring 10-Hz rhythm in sympathetic nerve discharge (SND) of urethan-anesthetized, baroreceptor-denervated cats. Intravenous doses of the 5-HT1A-receptor agonists 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT) and U-93385E, which inhibit the firing of serotonergic medullary raphe neurons, decreased the power in the 10-Hz band of SND without affecting the power at frequencies < or = 6 Hz. The inhibitory effects of 8-OH-DPAT and U-93385E were reversed by the 5-HT1A-receptor antagonists spiperone and WAY-100135. Microinjection of 8-OH-DPAT into medullary raphe nuclei also selectively eliminated the 10-Hz rhythm in SND. Intravenous administration of the 5-HT2-receptor antagonist methysergide blocked the 10-Hz rhythm in SND, whereas the 5-HT2-receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane increased peak frequency and power in the 10-Hz band of SND. Microinjection of N-methyl-D-aspartic acid into the medullary raphe also enhanced the 10-Hz rhythm in SND. These data support the view that the naturally occurring discharges of serotonergic medullary raphe neurons preferentially enhance the 10-Hz rhythm in SND.

scholarly journals The role of ‘jackpot’ stimuli in maladaptive decision-making: dissociable effects of D1/D2 receptor agonists and antagonists

2018 ◽  
Vol 235 (5) ◽  
pp. 1427-1437 ◽  
Author(s):  
Aaron P. Smith ◽  
Rebecca S. Hofford ◽  
Thomas R. Zentall ◽  
Joshua S. Beckmann
Keyword(s):  
Decision Making ◽  
D2 Receptor ◽  
Receptor Agonists ◽  
Receptor Agonists And Antagonists

scholarly journals The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

2021 ◽  
Vol 12 ◽  
Author(s):  
Joachim Neumann ◽  
Uwe Kirchhefer ◽  
Stefan Dhein ◽  
Britt Hofmann ◽  
Ulrich Gergs
Keyword(s):  
Potential Role ◽  
Histamine Receptor ◽  
Histamine Receptors ◽  
Clinical Role ◽  
Receptor Agonists ◽  
Functional Relationships ◽  
Mammalian Heart ◽  
Electrophysiological Effects ◽  
Receptor Agonists And Antagonists

This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H2-histamine-receptors in cardiac diseases will be examined. The use of H2-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H2-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H2-histamine receptor antagonists in treating chronic heart failure in animal models and patients will be reviewed. Some limitations in our biochemical understanding of the cardiac role of H2-histamine receptors will be discussed. Recommendations for further basic and translational research on cardiac H2-histamine receptors will be offered. We will speculate whether new knowledge might lead to novel roles of H2-histamine receptors in cardiac disease and whether cardiomyocyte specific H2-histamine receptor agonists and antagonists should be developed.

Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era

2020 ◽  
Vol 20 ◽  
Author(s):  
Giuseppe Lassandro ◽  
Valentina Palladino ◽  
Giovanni Carlo Del Vecchioa ◽  
Viviana Valeria Palmieri ◽  
Paola Carmela Corallo ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Treatment Options ◽  
Thrombopoietin Receptor Agonists ◽  
Receptor Agonists ◽  
Thrombopoietin Receptor ◽  
Related Quality ◽  
Health Related

Background and Objective: Immune thrombocytopenia (ITP) is a common bleeding disorder in childhood. The management of ITP in children is controversial, requiring personalized assessment of patients and therapeutic choices. Thrombopoietin receptor agonists (TPO-RAs), eltrombopag and romiplostim, have been shown to be safety and effective for the treatment of pediatric ITP. The aim of our research is defining the role of thrombopoietin receptor agonists in the management of pediatric ITP. Method: This review focuses on the use of TPO-RAs in pediatric ITP, in randomized trials and in clinical routine, highlighting their key role in management of the disease. Results: Eltrombopag and romiplostim appear effective treatment options for children with ITP. Several clinical studies have assessed that the use of TPO-RAs increases platelet count, decreases bleeding symptoms and improves health-related quality of life. Moreover, TPO-RAs are well tolerated with minor side effects. Conclusion: Although TPO-RAs long term efficacy and safety still require further investigations, their use is gradually expanding in clinical practice of children with ITP.

scholarly journals GLP‐1 receptor agonists and their cardiovascular benefits ‐ the role of the GLP‐1 receptor

2021 ◽  
Author(s):  
Johanna Helmstädter ◽  
Karin Keppeler ◽  
Leonie Küster ◽  
Thomas Münzel ◽  
Andreas Daiber ◽  
...  
Keyword(s):  
Receptor Agonists
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