Determination of Se(IV) in Pharmaceuticals by Using Different Operating Modes of Pulse Anodic Stripping Voltammetric Analysis with Methylene Blue-Nafion Modified Gold Electrode

The effect of gold electrode modified with 2,3-Diaminonaphthalene (GEMDANN) or multi-modified or a mixture 2,3-diaminonaphthalene and o-phenylenediamine -nafion (GEMDAN-OPDAN) on determination of selenium (IV) using differential pulse anodic stripping voltammetric analysis (DPASVA) has been studied. Various parameters (electrolyte, deposition time, pulse duration, pulse amplitude, etc.) are affecting determination of the Se(IV) in HClO4 (0.2 M) at pH 0.22 were examined. Under the optimum conditions, liner calibration graph, Ip=f(CSe4+), were obtained in the concentration ranges of 5x10-8 - 1x10-6 M (3.948 -78.96 ng.mL-1 ) with relative standard deviations (RSD) 4.2% and detection limit 0.056 ng.mL-1, and 1x10-9 -1x10-6 M (0.07896 -78.96 ng.mL-1 ) with relative standard deviations (RSD) 4.9% and detection limit was 0.014 ng.mL-1 on GEMDANN and GEMDAN-OPDAN, respectively. This method showed a good accumulation efficiency for selenium and good resistance to interferences from metal ions as well as those associated with selenium in pharmaceuticals. The results for the determination of Se4+ using GEMDAN-OPDAN (multi-modified) were more sensitive (about 50 times) than that obtained using GEMDANN.

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DEVELOPMENT AND VALIDATION OF DIFFERENTIAL PULSE ANODIC STRIPPING VOLTAMMETRIC ANALYSIS OF SELENIUM (IV) IN BULK AND IN DOSAGE FORMULATIONS AT A GOLD ELECTRODE MULTI-MODIFIED WITH A MIXTURE OF 3, 3′-DIAMINOBENZIDINE.4HCL AND VITAMIN E

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i7.18568 ◽

2017 ◽

Vol 9 (7) ◽

pp. 97

Author(s):

Abdul Azizs Ramadan ◽

Hasna Mandil ◽

Abdulrahman Shikh-debes

Keyword(s):

Vitamin E ◽

Gold Electrode ◽

Pulse Amplitude ◽

Differential Pulse ◽

Solution Stability ◽

Voltammetric Analysis ◽

Relative Standard ◽

Anodic Stripping ◽

The Individual

Objective: A simple, direct and very sensitive differential pulse anodic stripping voltammetric analysis (DPASVA) of selenium (IV) in bulk and in dosage formulations using a gold electrode multi-modified with a mixture of 3,3′-diaminobenzidine.4HCl (Dab) and vitamin E (VE)-Nafion (AuEMDabVEN) has been studied.Methods: The method involves the study of various parameters (electrolyte, deposition time, pulse duration, pulse amplitude, etc.) affecting the Se(IV) determination. The proposed method was validated for specificity, linearity, precision and accuracy, repeatability, sensitivity (LOD and LOQ), robustness and solution stability with an average recovery of 98.1-100.32%.Results: Se(IV)was determined in an aqueous HClO4 (0.2M) medium of pH 0.22 at an accumulation potential of-250 mV and an accumulation time of 200 s for CSe(IV) at 1x10-8 to 1x10-6 mol/l (0.7896-78.96 ng/ml) and 350 s for CSe(IV) at 1x10-9 to 1x10-8 mol/l (0.07896-0.7896 ng/ml) with relative standard deviations (RSD)2.4% and 4.8%, respectively.Conclusion: This method showed very sensitive results for the determination of Se(IV) using an AuEMDabVEN than that obtained using the individual Dab or VE. This method could be applicable for the quantitative determination of the bulk Se(IV) as well as dosage formulations.

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Development of Gold Electrode Modified With Sodium Diethyldithiocarbamate-Nafion to Determine Selenium (IV) in Bulk and in Dosage Formulations Using Differential Pulse Anodic Stripping Voltammetric Analysis

International Journal of Current Research in Chemistry and Pharmaceutical Sciences ◽

10.22192/ijcrcps.2020.07.07.002 ◽

2020 ◽

Vol 7 (7) ◽

pp. 11-23

Author(s):

Abdul Aziz Ramadan ◽

◽

Hasna Mandil ◽

Abdul Rahman Shikh-Debes ◽

◽

...

Keyword(s):

Gold Electrode ◽

Differential Pulse ◽

Sodium Diethyldithiocarbamate ◽

Voltammetric Analysis ◽

Anodic Stripping

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Determination of clopidogrel using square wave voltammetry at a gold electrode

Journal of the Serbian Chemical Society ◽

10.2298/jsc130913116m ◽

2013 ◽

Vol 78 (12) ◽

pp. 2131-2140 ◽

Cited By ~ 6

Author(s):

Aleksandar Mladenovic ◽

Vladislava Jovanovic ◽

Slobodan Petrovic ◽

Dusan Mijin ◽

Sasa Drmanic ◽

...

Keyword(s):

Gold Electrode ◽

Square Wave Voltammetry ◽

Pharmaceutical Preparation ◽

Antiplatelet Agent ◽

Hplc Method ◽

Tablet Form ◽

Square Wave ◽

Wave Voltammetry ◽

Anodic Stripping

The determination of clopidogrel, an antiplatelet agent, was performed at a gold electrode in pH 3.7 acetate buffer using cyclic voltammetry (CV) and square wave voltammetry (SWV). Each voltammogram is characterized by the well defined peak at approximately 1.0 V. The current of anodic stripping peak exhibits linear dependence on the clopidogrel concentration in a range from 317.89 mg cm-3 to 935.16 mg cm-3. The obtained linearity was applied to determine clopidogrel amount in the tablet form of pharmaceutical preparation (Plavix?). The results were compared to the UV spectrophotometric and HPLC method.

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