scholarly journals Solid Phase Synthesis and Antimicrobial Activity of Novel Triazolo[1,5-a]pyrimidine Derivatives

2020 ◽  
Vol 32 (9) ◽  
pp. 2298-2302
Author(s):  
SHOBHANA A. GADARA ◽  
KARTIK D. LADVA
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Dilution Method ◽  
Pyrimidine Derivatives ◽  
Phase Synthesis ◽  
Inhibition Concentration ◽  
Broth Dilution

A new series of triazolo[4,3-a]pyimidine derivatives via solid phase multicomponent reaction between 3-oxo-N-(4-(3-oxomorpholino)- phenyl)butanamide, aromatic aldehyde and aminoazole is reported. All the synthesized compounds have been characterized by elemental analysis and spectral analyses. Moreover, the synthesized compounds were also screened for their antibacterial activity against Staphylococcus aureus MTCC-96, Escherichia coli MTCC-443, Bacillus subtilis MTCC-441, Pseudomonas aeruginosa MTCC 1688, and antifungal activity against Aspergillus niger MTCC-282 and Penicillium sp. at different concentration and compared with standards drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro-broth dilution method.

scholarly journals Copper Catalyzed Chan-Lam Coupling Reaction of Pyrazoles at Ambient Temperature and their Antimicrobial Evaluation

2019 ◽  
Vol 31 (12) ◽  
pp. 2981-2985
Author(s):  
Kalpesh V. Vilapara ◽  
Sagar P. Gami ◽  
Shobhna A. Gadara ◽  
Yogesh T. Naliapara
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Boronic Acid ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Dilution Method ◽  
Aspergillus Clavatus ◽  
Inhibition Concentration ◽  
Antimicrobial Evaluation ◽  
Broth Dilution

An efficient protocol to synthesize a series of N-aryl pyrazoles via C-N bond Chan-Lam coupling reaction using diverse boronic acid at room temperature using Cu(OAc)2/TEA as a catalytic system without utilization of any ligand or additive and exposed to air to afford moderate to excellent yield. The characterizations of newly synthesized compounds were confirmed by FTIR, MS, 1H NMR, 13C NMR, and elemental analysis. All the synthesized compounds were assayed for their antibacterial activity against Staphylococcus aureus MTCC-96, Escherichia coli MTCC-443, B. subtilis MTCC-441, S. typhi MTCC-98, and antifungal activity against Aspergillus niger MTCC-282 and Aspergillus clavatus MTCC-1323 at different concentration and compared with standards drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method.

Solid-Phase Synthesis and Inhibitory Effects of Some Pyrido[1,2-c]pyrimidine Derivatives on Leukocyte Functions and Experimental Inflammation

2001 ◽  
Vol 44 (6) ◽  
pp. 1011-1014 ◽  
Author(s):  
Pedro Molina ◽  
Enrique Aller ◽  
Ángeles Lorenzo ◽  
Pablo López-Cremades ◽  
Inmaculada Rioja ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Inhibitory Effects ◽  
Pyrimidine Derivatives ◽  
Phase Synthesis ◽  
Experimental Inflammation

Improved solid-phase synthesis of α,α-dialkylated amino acid-rich peptides with antimicrobial activity*

2008 ◽  
Vol 66 (6) ◽  
pp. 333-347 ◽  
Author(s):  
S.R. Haynes ◽  
S.D. Hagins ◽  
M.M. Juban ◽  
P.H. Elzer ◽  
R.P. Hammer
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Solid-Phase Synthesis of 5-Arylhistidine-Containing Peptides with Antimicrobial Activity Through a Microwave-Assisted Suzuki-Miyaura Cross-Coupling

2012 ◽  
Vol 2012 (23) ◽  
pp. 4321-4332 ◽  
Author(s):  
Iteng Ng-Choi ◽  
Marta Soler ◽  
Vanessa Cerezo ◽  
Esther Badosa ◽  
Emilio Montesinos ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Phase Synthesis ◽  
Microwave Assisted

scholarly journals New Iridoid from Aerial Parts of Mussaenda Roxburghii

2012 ◽  
Vol 7 (1) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Utpal Chandra De ◽  
Ranjit Ghosh ◽  
Sanjib Chowdhury ◽  
Biswanath Dinda
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
2D Nmr ◽  
Dilution Method ◽  
Chemical Methods ◽  
Aerial Parts ◽  
Broth Dilution

A new iridoid, shanzhiol (1), was isolated from the aerial parts of Mussaenda roxburghii. The structure was established by spectroscopic (including 2D NMR) and chemical methods. Shanzhiol (1) showed mild antibacterial activity against both Staphylococcus aureus and Escherichia coli with a MIC of 100 μg/mL by the broth dilution method.

scholarly journals DAYA ANTIBAKTERI EKSTRAK ETANOL DAUN SENGGANI (Melastoma affine D. Don)

Biomedika ◽  
2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Ika Trisharyanti Dian Kusumowati ◽  
Rosita Melannisa ◽  
Angga Prasetyawan
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Mobile Phase ◽  
Ethanolic Extract ◽  
Test Method ◽  
Dilution Method ◽  
Tube Test ◽  
Inhibition Concentration ◽  
Layer Chromatography ◽  
Chloroform Methanol

Melastoma affine D. Don had some activities such as anthelmintic, antibacteria, antiinfiammation, antifungal, and antitumor. The aims of this research was determine antibacteria activity of ethanolic extract of Melastoma affine D. Don. The antimicrobial activity was tested by solid dilution method to get Minimum Inhibition Concentration (MIC). The compounds in Melastoma affine D. Don was analyzed by tube test method and Thin Layer Chromatography (TLC) with chloroform : methanol : formic acid (8,5:1,5:0,5) as mobile phase and silica gel GF254 as stationary phase. The result showed ethanolic extract of Melastoma affine D. Don contains alkaloid, polyphenol, fiavonoid, saponin, and essential oil. The MIC of Senggani against Staphylococcus aureus was 2% and 3% against Escherichia coli and the extract could not inhibit Staphylococcus aureus and Escherichia coli multiresistant until concentration 7% extract ethanol.Keywords: Melastoma affine D. Don, Staphylococcus aureus, Escherichia coli

scholarly journals Spermicidal and Antibacterial Effects of Oncoba welwitschii Oliv. (Salicaceae)

2020 ◽  
pp. 59-67
Author(s):  
Odette N. Kabena ◽  
Naomie E. Nyakembe ◽  
Jean Jacques D. Amogu ◽  
Lionel S. Asamboa ◽  
Emmanuel M. Lengbiye ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Vaginal Flora ◽  
Dilution Method ◽  
Antibacterial Effects ◽  
Additional Information ◽  
Bactericidal Effects ◽  
The University ◽  
And Staphylococcus Aureus

Aim: The aim of this work is to evaluate the spermicidal, antimicrobial activity of Oncoba welwitchii Oliv. This will justify its use on reproductive health especially in the occurrence of infertility and the imbalance of vaginal flora. Carried out at the Department of Biology of the Faculty of Sciences of the University of Kinshasa, between January and May 2019, this study was initiated to determine the effect of the use of O. welwitchii Oliv. on human spermatozoa and vaginal microorganisms. Methodology: The leaves of O. welwitchii Oliv. were collected and identified at University of Kinshasa. The spermicidal effect was performed by the Sander-Cramer method and antibacterial activity were evaluated by liquid dilution method. Results: The results revealed that the juice of the leaves of O. welwitchii Oliv. have a spermicidal effect, as this juice reduce the initial mobility of the spermatozoids after 60 minutes of the exposure from 72±12% to 1±2% and their initial viability from 74±11% to 10±18%. This juice has shown bacteriostatic effects against Escherichia coli and Staphylococcus aureus (MBC/MIC > 4) and bactericidal effects against Lactobacilus acidophilus (MBC/MIC ≤ 4). Conclusion: This study gives additional information on the phytochemistry composition and a spermicidal effects of O. welwitchii Oliv. The spermicidal effects of this plant could be associated to its acidity. It should be noted that to the best of our knowledge, no study on the phytochemistry of O. welwitchii Oliv. is available in the literature.

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