scholarly journals ISOLATED INVOLVEMENT OF CERVICAL LYMPH NODES IN CASTLEMAN’S DISEASE IN A YOUNG PATIENT: A RARE PRESENTATION

2016 ◽  
Vol 5 (39) ◽  
pp. 2405-2407
Author(s):  
Madhu S D ◽  
Parvathi M ◽  
Divya Lakshmi ◽  
Sneha Volvoikar
Keyword(s):  
Lymph Nodes ◽  
Young Patient ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Rare Presentation ◽  
Cervical Lymph Nodes

Castleman's Disease Masquerading as Sigmoid Colon Tumor and Hodgkin Lymphoma

Swiss Surgery ◽  
2002 ◽  
Vol 8 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Altinli ◽  
Pekmezci ◽  
Balkan ◽  
Somay ◽  
M. Akif Buyukbese ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Sigmoid Colon ◽  
Castleman’S Disease ◽  
Malignant Potential ◽  
Colon Tumor ◽  
Rare Entity ◽  
Castleman's Disease ◽  
Mediastinal Lymph Nodes ◽  
Histologic Types

Castleman's disease is a benign lymphoid neoplasm first reported as hyperplasia of mediastinal lymph nodes. Some authors referred to the lesions as isolated tumors, described as a variant of Hodgkin's disease with a possibility of a malignant potential and others proposed that the lymphoid masses were of a hamartomatous nature. Three histologic variants and two clinical types of the disease have been described. The disease may occur in almost any area in which lymph nodes are normally found. The most common locations are thorax (63%), abdomen (11%) and axilla (4%). We report two separate histologic types of Castleman's disease which were rare in the literature, mimicking sigmoid colon tumor and Hodgkin lymphoma. The diagnostic and therapeutic aspects of this rare entity is discussed.

scholarly journals Unicentric Castleman’s Disease in a Man Originally Diagnosed with Sarcoidosis: A Case and Analysis of the Key Differences in Diagnosis

2019 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Lymph Nodes ◽  
Surgical Resection ◽  
Lymphoproliferative Disorder ◽  
Castleman’S Disease ◽  
Castleman Disease ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Complete Surgical Resection ◽  
Vascular Proliferation

Castleman Disease (CD) is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. There are two types: unicentric and multicentric. Unicentric, hyalinevascular type of Castleman’s disease can be treated successfully with complete surgical resection with monitoring for reoccurrence. Here we report a case of a patient originally diagnosed with sarcoidosis who was found to have Unicentric Castleman’s disease.

scholarly journals Rare Presentation of Self-Limiting Kikuchi–Fujimoto Disease in Relapsing Nature

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Karo Servatyari ◽  
Hero Yazdanpanah ◽  
Chamara Dalugama
Keyword(s):  
Lymph Nodes ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Cervical Lymphadenopathy ◽  
Excision Biopsy ◽  
Presentation Of Self ◽  
Rare Presentation ◽  
Cervical Lymph Nodes ◽  
One Year ◽  
Loss Of Appetite

Background. Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limiting disease that is commonly associated with cervical lymphadenopathy and fever. The disease has a wide spectrum of clinical manifestations, and definitive diagnosis is based on the histological appearance in the excision biopsy of the lymph nodes. Recurrence of KFD is reported rarely. Case Presentation. A 56-year-old Iranian woman with a background history of thrombocytopenia presented with fever, malaise, loss of appetite, and weight loss with cervical lymphadenopathy. The excision biopsy of the cervical lymph nodes confirmed the diagnosis of KFD, and she made a full recovery with improvement of symptoms, regression of cervical lymph nodes, and normalization inflammatory markers. One year after remission, she presented with similar clinico-biochemical profile, and repeat biopsy confirmed KFD. Conclusion. Although the rate of recurrence of the disease is very low, the treating physician should consider the possibility and confirm it histologically.

Ocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes

2019 ◽  
pp. 112067211987007
Author(s):  
Jayati Sarangi ◽  
Aanchal Kakkar ◽  
Diya Roy ◽  
Rishikesh Thakur ◽  
Chirom Amit Singh ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Histopathological Examination ◽  
Previous History ◽  
Rare Presentation ◽  
Cervical Lymph Nodes ◽  
Extranodal Extension ◽  
Positron Emission ◽  
Parotid Neoplasm ◽  
History Of ◽  
The Right

Purpose: To describe a rare presentation of a case of intraocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes. Case description: A 9-year-old male child with previous history of ciliary body non-teratoid medulloepithelioma presented with a swelling in the right pre-auricular region for 1 month. Magnetic resonance imaging and positron emission tomography–computed tomography showed a right intraparotid mass with enlarged ipsilateral cervical lymph nodes. A core biopsy was taken from the lesion, which on microscopy showed a tumor composed of small round cells arranged in cords, tubules lined by multilayered cells, and in cribriform pattern. These cells were embedded in a hypocellular, loose myxoid matrix. Based on the histopathological characteristics and previous history, a diagnosis of medulloepithelioma metastastic to ipsilateral parotid gland was made. The patient underwent right total conservative parotidectomy and bilateral neck dissection. Histopathological examination revealed metastatic medulloepithelioma in five out of eight intraparotid lymph nodes, with extranodal extension into the adjacent parotid parenchyma. Foci of hyaline cartilage were identified within the tumor, leading to a diagnosis of metastatic teratoid medulloepithelioma. Conclusion: Intraparotid lymph node metastases from intraocular medulloepithelioma is a rare possibility and we recommend that the parotid should be evaluated in cases of intraocular medulloepithelioma at initial presentation as well as during the follow-up period. Also, metastasis should be considered in all pediatric patients with solitary mass lesions showing unconventional histology for a primary parotid neoplasm.

scholarly journals Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease

Blood ◽  
1989 ◽  
Vol 74 (4) ◽  
pp. 1360-1367 ◽  
Author(s):  
K Yoshizaki ◽  
T Matsuda ◽  
N Nishimoto ◽  
T Kuritani ◽  
L Taeho ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Acute Phase ◽  
Interleukin 6 ◽  
Acute Phase Proteins ◽  
Castleman’S Disease ◽  
Germinal Centers ◽  
Surgical Removal ◽  
Castleman's Disease ◽  
Lymph Node Hyperplasia

Abstract Castleman's disease is a syndrome consisting of giant lymph node hyperplasia with plasma cell infiltration, fever, anemia, hypergammaglobulinemia, and an increase in the plasma level of acute phase proteins. It has been reported that clinical abnormalities disappear after the resection of the affected lymph nodes, suggesting that products of lymph nodes may cause such clinical abnormalities. Interleukin-6 (IL-6) is a cytokine inducing B-cell differentiation to immunoglobulin-producing cells and regulating biosynthesis of acute phase proteins. This report demonstrates that the germinal centers of hyperplastic lymph nodes of patients with Castleman's disease produce large quantities of IL-6 without any significant production of other cytokines. In a patient with a solitary hyperplastic lymph node, clinical improvement and decrease in serum IL-6 were observed following surgical removal of the involved lymph node. There was a correlation between serum IL-6 level, lymph node hyperplasia, hypergammaglobulinemia, increased level of acute phase proteins, and clinical abnormalities. The findings in this report indicate that the generation of IL-6 by B cells in germinal centers of hyperplastic lymph nodes of Castleman's disease may be the key element responsible for the variety of clinical symptoms in this disease.

scholarly journals Extranodal (cutaneous) Rosai Dorfman: a rare presentation

2017 ◽  
Vol 6 (1) ◽  
pp. 370
Author(s):  
Ashwini Khadatkar ◽  
Nishant Ghodake
Keyword(s):  
Lymph Nodes ◽  
Clinical Course ◽  
Unknown Etiology ◽  
Extranodal Involvement ◽  
Rare Presentation ◽  
Cervical Lymph Nodes ◽  
Rosai Dorfman Disease

Rosai Dorfman disease is a rare histiocytic disorder of unknown etiology commonly involving the cervical lymph nodes first described in 1969, Extranodal involvement is very rare. Clinical course is variable.

scholarly journals Coexistence of Hodgkin’s Lymphoma and Castleman’s Disease: A Case Report with Successful Response to Chemotherapy and Radiotherapy

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Amina Mohtaram ◽  
Mohammed Afif ◽  
Tanae Sghiri ◽  
Amal Rami ◽  
Rachida Latib ◽  
...  
Keyword(s):  
Lymph Node ◽  
Hodgkin's Disease ◽  
Cervical Lymph Node ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin’S Disease ◽  
Castleman’S Disease ◽  
Hodgkin's Lymphoma ◽  
Castleman's Disease ◽  
Cervical Lymph Nodes ◽  
Response To Chemotherapy

Background. Castleman’s disease is a rare clinicopathological entity of unknown origin. Coexistence of Hodgkin’s lymphoma and Castleman’s disease is rare. We report a case of Hodgkin’s disease of cervical lymph nodes in a patient previously diagnosed with Castleman’s disease.Case Presentation. A 43-year-old man admitted in July 2009 for a right cervical pain with lymph node at the physician examination. He underwent a right adenectomy and histological studies showed typical features of Castleman’s disease. Three years after, the patient consulted for increasing the volume of cervical lymph node. Clinical examination showed a right cervical lymph node of 3 cm. The computed tomography scan of chest, abdominal and pelvic was normal. Histological and immunohistochemical studies of cervical lymph node biopsy specimen were in favor of Castleman’s disease associated with Hodgkin’s disease. Reed-Sternberg cells were positive for CD15 and CD30. The patient received chemotherapy based on anthracyclines, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy with complete response.Conclusion. Prevalence of Hodgkin’s lymphoma in Castleman’s disease is more difficult to establish because of the low number of cases reported in the literature.

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