scholarly journals A COMPARATIVE STUDY OF CLINICO-IMMUNOLOGICAL RESPONSE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY IN HIV AND HIV-HCV CO-INFECTION IN MANIPUR

2017 ◽  
Vol 6 (24) ◽  
pp. 1968-1971
Author(s):  
Amrita Mangar ◽  
Narmada Thongam ◽  
Thongam Bhimo Singh ◽  
Karam Romeo Singh ◽  
Narendra Singh R K
Keyword(s):  
Antiretroviral Therapy ◽  
Comparative Study ◽  
Highly Active Antiretroviral Therapy ◽  
Immunological Response ◽  
Highly Active

scholarly journals Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Samad Rasul ◽  
Robert Delapenha ◽  
Faria Farhat ◽  
Jhansi Gajjala ◽  
Syeda Mehreen Zahra
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Immunological Response ◽  
Signs And Symptoms ◽  
Graves Disease ◽  
Typically Develop ◽  
Highly Active ◽  
Inflammatory Syndrome ◽  
Haart Therapy

Graves' disease after the initiation of highly active antiretroviral therapy (HAART) in certain HIV-1-infected individuals has been described as an immune reconstitution inflammatory syndrome (IRIS). This phenomenon should be suspected in individuals who present with clinical deterioration and a presentation suggestive of hyperthyroidism despite good virological and immunological response to HAART. Signs and symptoms of hyperthyroidism may be discrete or overt and typically develop 8–33 months after initiating therapy. One to two percent of HIV-infected patients can present with overt thyroid disease. Relatively few cases of Graves' IRIS have been reported in the literature to date. We describe four cases of Graves' IRIS in HIV-infected patients who were started on HAART therapy.

scholarly journals Reasons for immunologic inefficiency of antiretroviral therapy in patients with HIV

2014 ◽  
Vol 95 (4) ◽  
pp. 581-588 ◽  
Author(s):  
A F Oleynik ◽  
V Kh Fazylov
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Immunological Response ◽  
Response To Treatment ◽  
Highly Active ◽  
Cell Counts ◽  
Increased Risk ◽  
Long Term Treatment ◽  
Cd4 Lymphocytes

The main component of the treatment of patients with HIV infection is highly active antiretroviral therapy (HAART), which can help to control the disease. The main goal of HAART is to increase the life duration and to maintain the quality of patients’ life. Improved survival among HIV-infected patients receiving highly active antiretroviral therapy is achieved mainly by a decrease of HIV RNA viral load, which increases CD4 lymphocytes count. However, some patients may present with discordant response to treatment, when there is no CD4 lymphocyte count elevation associated with the virus disappearing from the blood. Such patients retain immunodeficiency, despite long-term treatment. The risk of opportunistic infections on the background of insufficient immunological response, despite viral replication suppression, is higher than in patients with good immunological response to treatment. Consistently low CD4 cell counts are associated with an increased risk of AIDS diagnosis. Furthermore, this group of patients shows a slight increase in mortality not associated with AIDS-defining illnesses. The reasons for the low CD4 lymphocytes count increase in some patients achieving virologic response to HAART remain unclear. The immunological efficacy of treatment depends on many factors: baseline CD4 count, duration of HIV infection prior to HAART initiation, age, co-infection with HCV, presence of secondary diseases and comorbidities, HAART regimens, IL-2 use and others. Literature review covers the phenomenon of immunological «non-response» to HAART, factors leading to its development, and possible methods of correction. Currently, there are more questions than answers in the area of immunological non-effectiveness of HAART in HIV-infected patients.

scholarly journals Immunological Response to Highly Active Antiretroviral Therapy in Children with Clinically Stable HIV‐1 Infection

2005 ◽  
Vol 192 (3) ◽  
pp. 445-455 ◽  
Author(s):  
Howard M. Rosenblatt ◽  
Kenneth E. Stanley ◽  
Lin Y. Song ◽  
George M. Johnson ◽  
Andrew A. Wiznia ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Immunological Response ◽  
Highly Active ◽  
Hiv 1

The Immunological Response to Highly Active Antiretroviral Therapy Is Linked to CD4+ T-Cell Surface CCR5 Density

2006 ◽  
Vol 43 (3) ◽  
pp. 377-378 ◽  
Author(s):  
Thierry Vincent ◽  
Pierre Portal??s ◽  
Vincent Baillat ◽  
Aur??lia Eden ◽  
Jacques Clot ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Surface ◽  
Highly Active Antiretroviral Therapy ◽  
Immunological Response ◽  
Cd4 T Cell ◽  
Highly Active
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