scholarly journals The Antidepressant Activity Of The New Tetrapeptide Neuroprotector Kk-1, Homologous Of Acth15-18 Sequence (An Experimental Study)

2017 ◽  
Vol 1 (3) ◽  
pp. 10-17
Author(s):  
Roman D. Deiko ◽  
Sergiy Yu. Shtrygol ◽  
Alexandr A. Kolobov ◽  
Andrey S Simbirtsev ◽  
Maria V. Mishchenko

Author(s):  
SRIRAM BS ◽  
RAVICHANDRA V

Objective: The objective of the study was to evaluate the antidepressant activity of quercetin in monosodium glutamate (MSG) model of depressed male mice. Methods: MSG was administered (500 mg/kg) to different groups of albino male mice daily for 21 days to induce depression. The interventions (Quercetin and imipramine) were started on day 9th and continued till 21st day. On 23rd day, mice are sacrificed, hippocampus and amygdala supernatant are subjected for analysis. p<0.05 was considered as statistically significant. Results: There was a statistically significant reduction in interleukin (IL)-6 levels in animals treated with quercetin and imipramine compared to control group (p<0.001). There was also a statistically significant increase in brain-derived neurotrophic factor (BDNF) levels in quercetin with MSG groups (p<0.05) and imipramine with MSG groups (p<0.01). There was no statistically significant difference in IL-6 and BDNF levels between the groups of animals treated with quercetin (100 mg/kg) and imipramine (10 mg/kg) alone. Conclusion: Quercetin appeared to have an antidepressant activity. More extensive research is required to substantiate and elucidate the role of quercetin in behavioral disorders such as depression.



Author(s):  
Vishal Ubale ◽  
Jugalkishore Jaju ◽  
Punam Gosavi ◽  
Ganesh Pawar ◽  
Shrikant Dharmadhikari ◽  
...  




Phytomedicine ◽  
2000 ◽  
Vol 7 (6) ◽  
pp. 463-469 ◽  
Author(s):  
S.K. Bhattacharya ◽  
A. Bhattacharya ◽  
K. Sairam ◽  
S. Ghosal


Author(s):  
Sonal Parekar ◽  
Shrikant Dharmadhikari ◽  
Jugalkishore Jaju ◽  
Ganesh Pawar ◽  
Rajvardhan Solunke


Author(s):  
Norio Baba ◽  
Norihiko Ichise ◽  
Syunya Watanabe

The tilted beam illumination method is used to improve the resolution comparing with the axial illumination mode. Using this advantage, a restoration method of several tilted beam images covering the full azimuthal range was proposed by Saxton, and experimentally examined. To make this technique more reliable it seems that some practical problems still remain. In this report the restoration was attempted and the problems were considered. In our study, four problems were pointed out for the experiment of the restoration. (1) Accurate beam tilt adjustment to fit the incident beam to the coma-free axis for the symmetrical beam tilting over the full azimuthal range. (2) Accurate measurements of the optical parameters which are necessary to design the restoration filter. Even if the spherical aberration coefficient Cs is known with accuracy and the axial astigmatism is sufficiently compensated, at least the defocus value must be measured. (3) Accurate alignment of the tilt-azimuth series images.





1962 ◽  
Vol 5 (4) ◽  
pp. 387-394 ◽  
Author(s):  
Bruce Quarrington ◽  
Jerome Conway ◽  
Nathan Siegel
Keyword(s):  


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