Characterization of the Clinical and Phenotypic Features of South Asian Patients with Inflammatory Bowel Disease at an IBD Referral Center in the United States

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S399-S400
Author(s):  
Vimal Bodiwala ◽  
Timothy F. Marshall ◽  
Darren Seril
Keyword(s):  
United States ◽  
Inflammatory Bowel Disease ◽  
South Asian ◽  
Bowel Disease ◽  
The United States ◽  
Referral Center ◽  
Asian Patients ◽  
Inflammatory Bowel ◽  
Phenotypic Features

South Asian Patients With Inflammatory Bowel Disease in the United States Demonstrate More Fistulizing and Perianal Crohn Phenotype

2020 ◽  
Vol 26 (12) ◽  
pp. 1933-1942 ◽  
Author(s):  
Sushrut Jangi ◽  
Alex Ruan ◽  
Joshua Korzenik ◽  
Punyanganie de Silva
Keyword(s):  
United States ◽  
Inflammatory Bowel Disease ◽  
South Asian ◽  
Bowel Disease ◽  
South Asians ◽  
The United States ◽  
Phenotypic Characteristics ◽  
Asian Patients ◽  
Inflammatory Bowel ◽  
White Patients

Abstract Background South Asians have recently been identified as having a rapidly rising incidence and prevalence of inflammatory bowel disease (IBD) throughout the world. However, longitudinal phenotypic studies of South Asians living in the United States remain scarce. Methods We retrospectively studied 171 South Asian patients with IBD treated at 2 US tertiary centers who presented between 2000 and 2016. South Asian IBD patients were randomly matched in a 1:2 ratio with sex and IBD subtype–matched (ulcerative colitis [UC] vs Crohn disease [CD]) white control patients (n = 342). Demographic and phenotypic characteristics were evaluated and compared between the 2 groups. Odds ratios (OR), logistic regression, and survival analysis were performed using R studio and STATA. Results 81 South Asian patients and 162 white patients had CD, and 90 South Asians and 180 white patients had UC. Among the CD group, South Asian patients were diagnosed at a median older age (age 28) than white patients (21 years; P < 0.003). Fistulizing disease (24.1% vs 8.6%; P < 0.002), perianal disease (20.3% vs 2.5%; P < 0.005), and presentation of rectal pain (16.2% vs 2.9%; P < 0.001) were more common among South Asian patients with CD than among white patients. After adjusting for covariates, South Asian patients with CD were less likely to be placed on thiopurines (OR = 0.36; P < 0.007) or to receive more than 1 biologic (OR = 0.42; P < 0.040). South Asian patients with UC were less likely to have proctitis (10% vs 22.2%; P < 0.022) and more likely to have primary sclerosing cholangitis (n = 7 vs n = 2; P < 0.007). South Asian patients born in the United States or those who had migrated before age 5 were younger at the age of IBD diagnosis (age 18.9 vs 32.4; P < 0.0005). Conclusion We found unique demographic and phenotypic characteristics among South Asian patients, including more penetrating disease in those with CD and less proctitis among those with UC, along with altered medication use patterns. Distinct environmental exposures and a potentially unique genetic profile of South Asian patients may confer this variable phenotypic expression, influencing management of this increasingly at-risk population.

P140 CURRENT STATUS OF HOME INFUSIONS FOR INFLAMMATORY BOWEL DISEASE IN THE UNITED STATES

2018 ◽  
Vol 154 (1) ◽  
pp. S72-S73 ◽  
Author(s):  
Bharati Kochar ◽  
Yue Jiang ◽  
Christopher F. Martin ◽  
Edward L. Barnes ◽  
Millie D. Long
Keyword(s):  
United States ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
The United States ◽  
Current Status ◽  
Inflammatory Bowel

scholarly journals In-hospital outcomes of inflammatory bowel disease in cannabis users: a nationwide propensity-matched analysis in the United States

2019 ◽  
Vol 7 (12) ◽  
pp. 252-252 ◽  
Author(s):  
Rupak Desai ◽  
Upenkumar Patel ◽  
Hemant Goyal ◽  
Afrina Hossain Rimu ◽  
Dipen Zalavadia ◽  
...  
Keyword(s):  
United States ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
The United States ◽  
Hospital Outcomes ◽  
Inflammatory Bowel

scholarly journals Prevalence of Inflammatory Bowel Disease in Pediatric and Adult Populations: Recent Estimates From Large National Databases in the United States, 2007–2016

2019 ◽  
Author(s):  
Yizhou Ye ◽  
Sudhakar Manne ◽  
William R Treem ◽  
Dimitri Bennett
Keyword(s):  
United States ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Fixed Effects ◽  
Adult Population ◽  
The United States ◽  
Adult Age ◽  
The Us ◽  
Inflammatory Bowel ◽  
National Databases

Abstract Background The latest estimate of the prevalence of inflammatory bowel disease (IBD) in the United States was based on 2009 data, which indicates a need for an up-to-date re-estimation. The objectives of this study were to investigate the prevalence of all forms of IBD including ulcerative colitis (UC), Crohn’s disease (CD), and IBD unspecified (IBDU). Methods Pediatric (age 2–17) and adult (age ≥18) IBD patients were identified from 2 large claims databases. For each year between 2007 and 2016, prevalence was calculated per 100,000 population and standardized based on the 2016 national Census. A fixed-effects meta-analytical model was used for overall prevalence. Results The pediatric prevalence of IBD overall increased by 133%, from 33.0/100,000 in 2007 to 77.0/100,000 in 2016. Among children, CD was twice as prevalent as UC (45.9 vs 21.6). Prevalence was higher in boys than girls for all forms of IBD, in contrast to the adult population where the prevalence was higher in women than men. We also found that the 10–17 age subgroup was the major contributor to the rising pediatric IBD prevalence. For adults, the prevalence of IBD overall increased by 123%, from 214.9 in 2007 to 478.4 in 2016. The prevalence rates of UC and CD were similar (181.1 vs 197.7) in 2016. Conclusions Inflammatory bowel disease continues to affect a substantial proportion of the US population. In 2016, 1 in 209 adults and 1 in 1299 children aged 2–17 were affected by IBD. Prevalence of IBD has been increasing compared with previously published 2009 data.

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