S1409 Helicobacter pylori (H. pylori) Eradication Rates and Antibiotic Resistance Pattern in Nigeria, West Africa: A Systematic Review

Abstract Objective Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran. Results The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).

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Antibiotic Resistance of Helicobacter Pylori and Influencing Factors in Yangzhou, China: a Cross-sectional Study

10.21203/rs.3.rs-198405/v1 ◽

2021 ◽

Author(s):

Yun Zhang ◽

Xinyi Feng ◽

Lijun Bian ◽

Yan Zhang ◽

Qian Li ◽

...

Keyword(s):

Helicobacter Pylori ◽

Antibiotic Resistance ◽

Gastrointestinal Symptoms ◽

Cross Sectional Study ◽

Resistance Rate ◽

Resistance Pattern ◽

Cross Sectional ◽

Chip Technology ◽

Resistance Patterns ◽

H Pylori

Abstract Background: The Helicobacter pylori (H. pylori) antibiotic resistance pattern differs geographically, knowledge of local antimicrobial resistance pattern is key to successful eradication. The current study was performed to investigate the resistance of H. pylori to 5 commonly used antibiotics in Yangzhou.Methods: A total of 461 H. pylori strains were collected from April 2018 to September 2019 in Yangzhou and tested for their susceptibility to clarithromycin, levofloxacin, metronidazole, amoxicillin, tetracycline using gene chip technology.Results: The resistance rates of H. pylori to clarithromycin, levofloxacin, metronidazole, amoxicillin and tetracycline were 41.0%, 44.9%, 38.8%, 6.3% and 1.1%. In addition, sixteen multiple resistance patterns were detected, and fortunately there were no strains resistant to all five antibiotics. The vacA s1 allele was detected in each strain, 64.0% of the isolates were s1/m2 genotype, 36.0% s1/m1 genotype. In multivariate analysis, history of chronic superficial gastritis was significantly associated with clarithromycin resistance, strains isolated from subjects with gastrointestinal symptoms had a significantly higher likelihood of metronidazole resistance, and antibiotic resistance of H. pylori was independent of both sex and age.Conclusion: The resistance rate of H. pylori to clarithromycin, levofloxacin and metronidazole were very high in Yangzhou, the results will help in selecting effective eradication regimens.

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Helicobacter pylori in a poultry slaughterhouse: Prevalence, genotyping and antibiotic resistance pattern

Saudi Journal of Biological Sciences ◽

10.1016/j.sjbs.2018.02.002 ◽

2018 ◽

Vol 25 (6) ◽

pp. 1072-1078 ◽

Cited By ~ 2

Author(s):

Mohamed Hamada ◽

Ayman Elbehiry ◽

Eman Marzouk ◽

Ihab M. Moussa ◽

Ashgan Mohamed Hessain ◽

...

Keyword(s):

Helicobacter Pylori ◽

Antibiotic Resistance ◽

Resistance Pattern ◽

Antibiotic Resistance Pattern

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Helicobacter pylori infection is an infectious disease and the empiric therapy paradigm should be changed

Precision Clinical Medicine ◽

10.1093/pcmedi/pbz009 ◽

2019 ◽

Vol 2 (2) ◽

pp. 77-80 ◽

Cited By ~ 3

Author(s):

Hong Li ◽

Tiankuo Yang ◽

Hong Tang ◽

Xiaoqiong Tang ◽

Yalin Shen ◽

...

Keyword(s):

Infectious Disease ◽

Helicobacter Pylori ◽

Antibiotic Resistance ◽

Antimicrobial Susceptibility ◽

Susceptibility Testing ◽

Empiric Therapy ◽

Helicobacter Pylori Infection ◽

Resistance Pattern ◽

Treatment Paradigm ◽

H Pylori

Abstract Helicobacter pylori infection is an infectious disease. Given the alarmingly high antibiotic resistance in H. pylori, gastroenterologists should change the empiric H. pylori treatment paradigm to an antimicrobial susceptibility testing-guided precision treatment. Antimicrobial stewardship programs for H. pylori should be implemented locally, regionally, and nationally to monitor the antibiotic resistance pattern.

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Antibiotic resistance pattern of Helicobacter pylori strains isolated in Italy during 2010–2016

Scandinavian Journal of Gastroenterology ◽

10.1080/00365521.2018.1464596 ◽

2018 ◽

Vol 53 (6) ◽

pp. 661-664 ◽

Cited By ~ 7

Author(s):

Giulia Fiorini ◽

Angelo Zullo ◽

Ilaria Maria Saracino ◽

Matteo Pavoni ◽

Dino Vaira

Keyword(s):

Helicobacter Pylori ◽

Antibiotic Resistance ◽

Resistance Pattern ◽

Antibiotic Resistance Pattern

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Prevalence, diagnosis and antibiotic resistance pattern of H. pylori in the patients with heterogeneous gastroduodenal disorders

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2020.09.332 ◽

2020 ◽

Vol 101 ◽

pp. 121

Author(s):

H. Pandya

Keyword(s):

Antibiotic Resistance ◽

Resistance Pattern ◽

Antibiotic Resistance Pattern ◽

H Pylori ◽

Gastroduodenal Disorders

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Bacterial Infections and Their Antibiotic Resistance Pattern in Ethiopia: A Systematic Review

Advances in Preventive Medicine ◽

10.1155/2019/4380309 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Alemayehu Reta ◽

Abebaw Bitew Kifilie ◽

Abeba Mengist

Keyword(s):

Systematic Review ◽

Antibiotic Resistance ◽

Bacterial Infections ◽

Bacterial Resistance ◽

Clinical Samples ◽

Resistance Pattern ◽

Bacterial Isolates ◽

Cross Sectional ◽

Antibiotic Resistance Pattern ◽

Open Access Journals

Background. Antibiotic resistance is a global challenge in the public health sector and also a major challenge in Ethiopia. It is truly difficult to report bacterial antibiotic resistance pattern in Ethiopia due to the absence of a review which is done comprehensively. The aim of this systematic review was to provide an overview of the works of literature on the antibiotic resistance pattern of the specific bacterial isolates that can be obtained from different clinical samples in the context of Ethiopia. Materials and Methods. A web-based search using PubMed, Google Scholar, Hinari, Sci Hub, Scopus and the Directory of Open Access Journals was conducted from April to May 2018 for published studies without restriction in the year of publication. Works of literature potentially relevant to the study were identified by Boolean search technique using various keywords: Bacterial infection, antimicrobial resistance, antibiotic resistance, drug resistance, drug susceptibility, anti-bacterial resistance, Ethiopia. Study that perform susceptibility test from animal or healthy source using <10 isolates and methods other than prospective cross-sectional were excluded. Results. The database search delivered a total of 3459 studies. After amendment for duplicates and inclusion and exclusion criteria, 39 articles were found suitable for the systematic review. All studies were prospective cross-sectional in nature. The review encompasses 12 gram-positive and 15 gram-negative bacteria with their resistance pattern for around 12 antibiotics. It covers most of the regions which are found in Ethiopia. The resistance pattern of the isolates ranged from 0% up to 100%. The overall resistance of M. tuberculosis for antituberculosis drugs ranges from 0% up to 32.6%. The percentage of resistance increases among previously treated tuberculosis cases. Neisseria gonorrhea, S. typhimurium, S. Virchow, Group A Streptococci (GAS), and Group B Streptococci (GBS) were highly susceptible for most of the tested antibiotics. Methicillin-Resistant Staphylococcus aureus was highly resistant to most of the antibiotics with a slightly increased susceptibility to gentamycin. Conclusions. Total bacterial isolates obtained from a different source of sample and geographic areas were 28, including M. tuberculosis. Majority of the bacterial isolates were resistant to commonly used antibiotics. A continuous monitoring and studies on the multidrug-resistant bacterial isolates are important measures.

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