Regular arrangement of collecting venules (RAC) as an endoscopic marker for exclusion of Helicobacter pylori (H. pylori) infection: A systematic review and meta‐analysis

Background: Helicobacter pylori (H. pylori) is the most common cause of gastric cancer. Growing evidence suggests that the regular arrangement of collecting venules (RAC) can be used as an endoscopic marker to diagnose H. pylori infection. However, data on the diagnostic accuracy of RAC for H. pylori infection are conflicting. We performed a systematic review and meta-analysis of relevant studies to determine the diagnostic accuracy and clinical utility of RAC for the diagnosis of H. pylori infection. Methods: We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library between inception and Oct 29, 2020, for studies that assessed the diagnostic accuracy of RAC for H. pylori infection. Results: The literature search yielded 2921 nonduplicated screened titles, of which 58 underwent full-text review. Fifteen studies, representing a total of 6621 patients, met the inclusion criteria. The area under the summary receiver operating characteristic curve was 0.98 (95% CI 0.96 to 0.99). The pooled estimates for RAC were 0.98 (95% CI 0.95 to 0.99) for sensitivity and 0.75 (95% CI 0.54 to 0.88) for specificity. The pooled positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 3.8 (95% CI 1.9 to 7.7) and 0.03 (95% CI 0.02 to 0.07), respectively. Conclusions: RAC can be used as an endoscopic marker for exclusion of H. pylori infection. However, it cannot be recommended as a single indicator for the confirmation of H. pylori infection. The conclusion of this study should be treated with caution because significant heterogeneity exists between the evaluated studies.

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Two-Way Relationship Between Helicobacter Pylori Infection and Periodontitis: Results from A Systematic Review and Meta-Analysis

10.31487/j.cei.2020.01.03 ◽

2020 ◽

pp. 1-7

Author(s):

Felipe Rodolfo ◽

Silvania Conceição Furtado ◽

Alessandro Luiz Araújo Bentes Leal ◽

Any Carolina Cardoso Guimarães Vasconcelos ◽

Daniel Fernando Pereira Vasconcelos ◽

...

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Current Systematic Review ◽

Increased Risk ◽

Statistical Program ◽

H Pylori ◽

Ci Calculations ◽

Review Manager

Aim: Helicobacter pylori (H. pylori) infection and periodontitis have considerable worldwide prevalence once they both present systemic alterations with a possible association between them. Therefore, we have performed this meta-analysis to assess the possible association between H. pylori infection and periodontitis. Material and Methods: A systematic search in the literature was performed for studies published before December 2, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical analysis was performed by Review Manager statistical program with heterogeneity and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations as well as a sensitive analysis to assess the accuracy of the results. The value of P<0.05 was considered as significant. In addition, we performed the analysis of the quality of included studies as well as the evaluation for risk of bias. Results: In overall analysis, H. pylori infection was associated with the risk of periodontitis development (OR = 1.72, CI: 1.47, 2.02, P<0.00001) and the periodontitis was considered as a risk factor for H. pylori infection (OR = 3.21, CI: 2.31, 4.47, P<0.00001). Moreover, the evaluation of dental plaque from patients with periodontitis reveled increased risk of H. pylori infection (OR = 3.46, CI: 2.39, 5.01, P<0.00001). Conclusions: This current systematic review and meta-analysis composed by 12 studies in 7,059 participants showed that H. pylori infection increased significantly the risk of the development of periodontitis and the periodontitis may be a risk for this bacterial infection.

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Association of Helicobacter pylori Infection with the Risk of Metabolic Syndrome and Insulin Resistance: An Updated Systematic Review and Meta-Analysis

10.21203/rs.3.rs-789572/v1 ◽

2021 ◽

Author(s):

Mobin Azami ◽

Hamid Reza Baradaran ◽

Parisa Kohnepoushi ◽

Lotfolah Saed ◽

Asra Moradkhani ◽

...

Keyword(s):

Systematic Review ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Helicobacter Pylori ◽

Cohort Studies ◽

Odds Ratio ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

H Pylori

Abstract Background Conflicting results of recent studies on the association between Helicobacter pylori (H. pylori) infection and the risk of insulin resistance and metabolic syndrome explored the need for updated meta-analysis on this issue. Therefore, this systematic review aimed to estimate the pooled effect of H. pylori infection on the risk of insulin resistance and metabolic syndrome. Methods To identify case-control studies and cohort studies evaluating the association of H. pylori infection with insulin resistance and metabolic syndrome, a comprehensive literature search was performed from international databases including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL from January 1990 until January 2021. We used odds ratio with its 95% confidence interval (95%CI) to quantify the effect of case-control studies and risk ratio with its 95%CI for the effect of cohort studies. Results 22 studies with 206911 participants were included for meta-analysis. The pooled estimate of odds ratio between H. pylori infection and metabolic syndrome in case-control studies was 1.19 (95%CI: 1.05, 1.35; I2 = 0%), and in cohort studies, the pooled risk ratio was 1.31 (95%CI: 1.13, 1.51; I2 = 0%). Besides, case-control studies showed the pooled odds ratio of 1.54 (95%CI: 1.19, 1.98; I2 = 6.88%) for the association between H. pylori infection and insulin resistance. Conclusion A positive association was found between H. pylori infection and insulin resistance as well as metabolic syndrome, so planning to eliminate or eradicate H. pylori infection could be an effective solution to improve metabolic syndrome or insulin resistance, and vice versa.

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Regular arrangement of collecting venules under endoscopy for predicting a Helicobacter pylori-negative stomach: A systematic review and meta-analysis

Gastroenterología y Hepatología (English Edition) ◽

10.1016/j.gastre.2020.08.005 ◽

2021 ◽

Vol 44 (4) ◽

pp. 286-292

Author(s):

Lunan Li ◽

Jiyong Jing ◽

Huiqin Gao ◽

Chenjing Zhang ◽

Haifang Lou ◽

...

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Regular Arrangement

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Relationship between Helicobacter pylori and development of hepatocellular carcinoma: A systematic review and meta-analysis.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.4091 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. 4091-4091

Author(s):

Samragnyi Madala ◽

Kira MacDougall ◽

Balarama Krishna Surapaneni ◽

Robin Park ◽

Anup Kasi ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Systematic Review ◽

Helicobacter Pylori ◽

Causal Relationship ◽

Subgroup Analysis ◽

Meta Analysis ◽

Control Group ◽

Significant Difference ◽

H Pylori ◽

The Relationship

4091 Background: The relationship between Helicobacter pylori (H.pylori) and hepatocellular carcinoma (HCC) was first proposed in 1994. Since then, several studies have been performed to explore the association. The role of Hepatitis C (HCV) viruses coexisting with H.pylori in causing HCC was also studied. With the emergence of data in this regard, a causal relationship has been postulated, but not confirmed, and hence the relationship remains controversial. Our meta-analysis aims to summarize the research on this topic and investigate if there exists a relationship between H. pylori infection and the development of HCC and if the presence of HCV along with H.pylori plays a role in liver carcinogenesis. Methods: Following PRISMA guidelines, we performed a systematic review of all relevant studies published in the literature using keywords “Helicobacter pylori” and “Hepatocellular carcinoma” on major literature databases, including PubMed, EMBASE, Web of Science, and Cochrane controlled trials register. A total of 656 studies were identified between 1994 to March 2020, out of which 26 studies qualified under our selection criteria. Patients positive for HCC are included as cases and patients that did not have HCC under control group. In both groups, H.pylori positive patients and their HCV status, was identified. Results: Out of the 26 studies included in the final analysis, the prevalence of H. pylori infection was 64.78% (561 of 866) amongst HCC cases and 47.92% (1718 of 3585) in the non-HCC control group. The summary odds ratio for the association of H. pylori infection with the risk for HCC using the random-effects model was determined to be 4.75 (95% CI, 3.06-7.37), I²=63%. Subgroup analysis to determine the odds of developing HCC in the presence of H.pylori and HCV coinfection, was 13.97 (95% CI, 3.94-49.61), I²=81%. Whereas, the odds of developing HCC in the presence of only HCV without H.pylori was found to be 2.21 (0.70-6.94), I²=79. Subgroup analysis by study design showed no significant difference between the study groups (P= 0.5705). Conclusions: Our meta-analysis showed a positive association between H. pylori infection and the development of HCC. It showed a significantly higher risk of developing HCC in the presence of HCV infection along with H.pylori. Further prospective cohort studies are needed to prove the causal relationship, especially in cases of Hepatitis B, C coinfection, and cirrhotic patients.[Table: see text]

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Atopy and Helicobacter Pylori (H, Pylori) infection: A Systematic Review and Meta-Analysis.

International Journal of Epidemiology ◽

10.1093/ije/dyv096.317 ◽

2015 ◽

Vol 44 (suppl_1) ◽

pp. i198-i198

Author(s):

B. Taye

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Meta Analysis ◽

H Pylori

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Association of Helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance: an updated systematic review and meta-analysis

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-021-00765-x ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Mobin Azami ◽

Hamid Reza Baradaran ◽

Hojat Dehghanbanadaki ◽

Parisa Kohnepoushi ◽

Lotfolah Saed ◽

...

Keyword(s):

Systematic Review ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Helicobacter Pylori ◽

Cohort Studies ◽

Odds Ratio ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

H Pylori

Abstract Background Conflicting results of recent studies on the association between Helicobacter pylori (H. pylori) infection and the risk of insulin resistance and metabolic syndrome explored the need for updated meta-analysis on this issue. Therefore, this systematic review aimed to estimate the pooled effect of H. pylori infection on the risk of insulin resistance and metabolic syndrome. Methods To identify case–control studies and cohort studies evaluating the association of H. pylori infection with insulin resistance and metabolic syndrome, a comprehensive literature search was performed from international databases including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL from January 1990 until January 2021. We used odds ratio with its 95% confidence interval to quantify the effect of case–control studies and risk ratio with its 95% CI for the effect of cohort studies. Results 22 studies with 206,911 participants were included for meta-analysis. The pooled estimate of odds ratio between H. pylori infection and metabolic syndrome in case–control studies was 1.19 (95% CI 1.05–1.35; I2 = 0%), and in cohort studies, the pooled risk ratio was 1.31 (95% CI 1.13–1.51; I2 = 0%). Besides, case–control studies showed the pooled odds ratio of 1.54 (95% CI 1.19–1.98; I2 = 6.88%) for the association between H. pylori infection and insulin resistance. Conclusion In this meta-analysis, the results showed that there was a possibility of metabolic syndrome and insulin resistance in case of H. pylori infection.

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A Systematic Review and Meta-Analysis on the Relation Between Helicobacter Pylori Infection and Atherosclerosis in the Iranian Population

10.21203/rs.3.rs-26342/v1 ◽

2020 ◽

Author(s):

Masoud Keikha ◽

Mohsen Karbalaei

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Atherosclerotic Plaques ◽

Cardiovascular Disorders ◽

Predisposing Factor ◽

Current Systematic Review ◽

High Prevalence ◽

Artery Disease ◽

H Pylori

Abstract Background: Various evidences have recently been provided indicating the relationship between infection with Helicobacter pylori and the extra-gastric complication, especially atherosclerosis. Atherosclerosis is the most important predisposing factor for cardiovascular disorders due to the high prevalence of cardiovascular disorders in developing countries (areas where a high population of people are infected with Helicobacter pylori), in particular in Iran.Methods: In a current systematic review and meta-analysis study, we collected all studies of the isolation of Helicobacter pylori from atherosclerotic plaques in Iranian cardiovascular patients to investigate the presence or absence of a relationship between Helicobacter pylori infection and susceptibility to atherosclerosis. The present meta-analysis was done by Comprehensive Meta-Analysis software (CMA-Ver. 2.0). This software has the ability to combine studies and impact sizes into the results and is highly acceptable.Results: Overall, the frequency of H. pylori in atherosclerotic plaques in the coronary artery disease (CAD) patients was estimated to be 41.30%. However, the highest and lowest frequency of infection with Helicobacter pylori were 80% and 0%, respectively.Conclusions: However generally, regarding the previous studies, we collected all the Iranian published articles and showed that the infection with Helicobacter pylori was significantly related with the atherosclerosis, but further complementary and more extensive studies are required to confirm this hypothesis.

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Artificial Intelligence for the Prediction of Helicobacter Pylori Infection in Endoscopic Images: Systematic Review and Meta-Analysis Of Diagnostic Test Accuracy (Preprint)

10.2196/preprints.21983 ◽

2020 ◽

Author(s):

Chang Seok Bang ◽

Jae Jun Lee ◽

Gwang Ho Baik

Keyword(s):

Artificial Intelligence ◽

Systematic Review ◽

Helicobacter Pylori ◽

Diagnostic Test ◽

Meta Analysis ◽

Diagnostic Test Accuracy ◽

Test Accuracy ◽

Endoscopic Images ◽

Number Of Patients ◽

H Pylori

BACKGROUND Helicobacter pylori plays a central role in the development of gastric cancer, and prediction of H pylori infection by visual inspection of the gastric mucosa is an important function of endoscopy. However, there are currently no established methods of optical diagnosis of H pylori infection using endoscopic images. Definitive diagnosis requires endoscopic biopsy. Artificial intelligence (AI) has been increasingly adopted in clinical practice, especially for image recognition and classification. OBJECTIVE This study aimed to evaluate the diagnostic test accuracy of AI for the prediction of H pylori infection using endoscopic images. METHODS Two independent evaluators searched core databases. The inclusion criteria included studies with endoscopic images of H pylori infection and with application of AI for the prediction of H pylori infection presenting diagnostic performance. Systematic review and diagnostic test accuracy meta-analysis were performed. RESULTS Ultimately, 8 studies were identified. Pooled sensitivity, specificity, diagnostic odds ratio, and area under the curve of AI for the prediction of H pylori infection were 0.87 (95% CI 0.72-0.94), 0.86 (95% CI 0.77-0.92), 40 (95% CI 15-112), and 0.92 (95% CI 0.90-0.94), respectively, in the 1719 patients (385 patients with H pylori infection vs 1334 controls). Meta-regression showed methodological quality and included the number of patients in each study for the purpose of heterogeneity. There was no evidence of publication bias. The accuracy of the AI algorithm reached 82% for discrimination between noninfected images and posteradication images. CONCLUSIONS An AI algorithm is a reliable tool for endoscopic diagnosis of H pylori infection. The limitations of lacking external validation performance and being conducted only in Asia should be overcome. CLINICALTRIAL PROSPERO CRD42020175957; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=175957

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A Systematic Review and Meta-analysis for Association of Helicobacter pylori Colonization and Celiac Disease

10.1101/2020.10.12.335836 ◽

2020 ◽

Author(s):

Fazel Isapanah Amlashi ◽

Zahra Norouzi ◽

Ahmad Sohrabi ◽

Hesamaddin Shirzad-Aski ◽

Alireza Norouzi ◽

...

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Celiac Disease ◽

Publication Bias ◽

Meta Analysis ◽

Negative Association ◽

Risk Of Bias ◽

Control Group ◽

Synthesis Methods ◽

H Pylori

AbstractBackground and objectivesBased on some previous observational studies there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CD), however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CD and human H. pylori colonization.Data sourcesStudies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated.Synthesis methodsMeta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed.ResultsTwenty-four studies were included in this systematic review, with a total of 5241 cases and 132947 control people. The results of meta-analysis on 24 studies showed a significant and negative association between H. pylori colonization and CD (pooled OR= 0.58; 95% CI = 0.45 - 0.76; P < 0.001), with no publication bias (P = 0.407). The L’Abbé plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity.ConclusionsAccording to the meta-analysis, H. pylori has a mild protective role toward CD. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CD patients.Systematic review registration number (PROSPERO)CRD42020167730

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