scholarly journals Morphological diagnosis of thyroid disease (lecture)

1999 ◽  
Vol 45 (5) ◽  
pp. 34-38
Author(s):  
M. E. Bronstein
Keyword(s):  
Thyroid Gland ◽  
Microscopic Examination ◽  
Thyroid Tissue ◽  
Needle Puncture ◽  
Pathological Changes ◽  
Fine Needle ◽  
Puncture Biopsy ◽  
Morphological Diagnosis ◽  
Fine Needle Puncture ◽  
Morphological Diagnostics

Morphological methods for studying the thyroid gland (thyroid gland) can clarify its structure and the nature of the pathological changes that developed in it, and thereby verify the diagnosis. There are 2 main methods of morphological diagnostics: microscopic examination of punctate obtained using a fine-needle puncture biopsy (aspiration and non-aspiration), and macro and microscopic examination of removed thyroid tissue.

scholarly journals Fine needle puncture biopsy and imaging methods of the thyroid gland in the diagnosis of nodular goiter

1993 ◽  
Vol 39 (6) ◽  
pp. 30-33
Author(s):  
S. L. Vnotchenko ◽  
T. A. Okeanova ◽  
M. E. Bronshtein ◽  
S. B. Nefedov ◽  
G. I. Fedoseeva
Keyword(s):  
Thyroid Gland ◽  
Ultrasound Examination ◽  
Nodular Goiter ◽  
Needle Puncture ◽  
Single Adenoma ◽  
Fine Needle ◽  
Cytological Data ◽  
Puncture Biopsy ◽  
Cystic Changes ◽  
Operational Data

A retrospective analysis of the results of puncture thyroid biopsy is presented in 256 patients operated on for nodular goiter. Cytological data coincided with histological in 84.8% of cases. Coincidences were most frequent with (multiple) nodular colloid goiter and thyroid cysts (95.7 = 100%) and the least with a single adenoma (65.4%) of predominantly follicular structure. In thyroid cancer, the data correlated in 75% of cases. The presence of cystic changes in the adenoma made the study less informative. The results of an ultrasound examination of the thyroid gland coincided with operational data in 87.5% of patients with (multiple) nodular goiter and in 86.1% of patients with adenomas. Ultrasonography as a method of imaging the thyroid gland is preferable to scintigraphy (scanning) and is the optimal complement to the thyroid puncture biopsy.

scholarly journals L-thyroxine in the treatment of solitary nodular non-toxic goiter in concomitant coronary heart disease

1999 ◽  
Vol 45 (3) ◽  
pp. 25-28
Author(s):  
E. A. Troshina ◽  
A. A. Alexandrov ◽  
G. A. Gerasimov ◽  
I. I. Dedov ◽  
A. I. Martynov ◽  
...  
Keyword(s):  
Patient Population ◽  
Nodular Goiter ◽  
Needle Puncture ◽  
Thyrotropic Hormone ◽  
Fine Needle ◽  
Biopsy Specimens ◽  
Puncture Biopsy ◽  
Coronary Patients ◽  
Toxic Goiter ◽  
Fine Needle Puncture

Endocrinological and cardiological parameters were assessed in coronary patients with nodular euthyroid goiter before and during treatment in order to define the optimal protocols of L-thyroxin therapy. Ultrasonic examination of the thyroid, fine needle puncture biopsy and cytological analysis of biopsy specimens, measurements of thyrotropic hormone, electrocardiography, and high resolution electrocardiography were carried out. The results helped distinguish the cardiological criteria for decreasing the dose of L-thyroxin or its discontinuation in coronary patients with nodular goiter and define the indications for such therapy in this patient population. Therapy with L-thyroxin is justified in the above patient population only on condition of monitoring the cardiovascular status. Therefore, the presence of coronary disease or its risk factors in a patient with nodular colloid proliferating goiter is not a contraindication preventing thyroxin therapy in adequate doses.

Cytological diagnosis of thyroid disease

2019 ◽  
Vol 43 (3) ◽  
pp. 30-38
Author(s):  
M. E. Bronstein
Keyword(s):  
Thyroid Gland ◽  
Microscopic Examination ◽  
Nodular Goiter ◽  
Needle Aspiration ◽  
Glass Slide ◽  
Malignant Neoplasms ◽  
Cytological Diagnosis ◽  
Pathological Changes ◽  
Medical Sciences ◽  
Puncture Biopsy

Cytological diagnosis of various human diseases is widely used in modern medicine, especially for early preoperative diagnosis of tumors of different organs and tissues. A fine-needle aspiration puncture biopsy followed by microscopic examination of its cytogram is one of the integral parts of diagnostic cytology, including the diagnosis of thyroid diseases (thyroid gland). The methods used to verify various thyroid pathology options (palpation, ultrasound - ultrasound, scintigraphy, biochemical and immunological tests, etc.) do not always allow us to clarify the nature of pathological changes in the thyroid gland. For example, cold nodes (according to the scan) only in some cases turn out to be malignant neoplasms of the thyroid gland, like the bulk of nodular goiter in patients from regions endemic to goiter; in most cases there is no need for their prompt removal. And only a microscopic examination of thyroid puncture points, especially its nodular formations, allows you to clarify the diagnosis and make an adequate decision on the nature of the treatment measures. Thin-needle aspiration puncture biopsy of the thyroid gland is a non-invasive morphological diagnostic tool that allows you to make a correct diagnosis with almost 100% probability. At the same time, since the thyroid gland is an epithelial organ, in the structures of which the cells are closely “fused” with each other, cellular connections are broken with difficulty, which makes it extremely difficult to obtain informative material for subsequent microscopic examination. To facilitate the process of obtaining material on the needle, which is performed by puncture biopsy, in the Endocrinology Research Center of the Russian Academy of Medical Sciences, notches were started at a distance of about 0.5-0.7 cm from the sharp end of the needle (Candidate of Medical Sciences A.V. Antonov), which allows you to take material like a harpoon, without aspiration and receive a plentiful punctate. With ischemia of the punctured area of the gland, it is possible to obtain abundant punctate with virtually no impurity of peripheral blood (Ph.D. I.V. Panteleev). The material thus obtained is applied to a fat-free glass slide and a smear is obtained using a polished glass slide (similar to a blood smear). Air-dried strokes are stained according to May — Grunwald — Giemsa. Every year we examine from 1.5 to 2.5 thousand puncture biopsies from patients with various pathologies. The information content of the obtained material largely depends on the experience and skill of the surgeon. Scanty punctate, as a rule, is uninformative and can only describe the punctate without an opinion on the nature of pathological changes in the thyroid gland. Abundant cellular punctate from different points of the gland, especially if there is a suspicion of diffuse and / or combined pathology, makes it possible to make a final diagnosis.

scholarly journals Certain peculiarities of parenchymal-stromal correlations in the thyroid gland with nodular forms of goiter with its rucurrent and non-recurrent course

2020 ◽  
Vol 19 (1) ◽  
pp. 53-60
Author(s):  
N. P. Tkachuk ◽  
I. S. Davydenko
Keyword(s):  
Thyroid Gland ◽  
Slow Growth ◽  
Thyroid Tissue ◽  
Nodular Goiter ◽  
Specific Weight ◽  
Pathological Changes ◽  
Normal Thyroid Tissue ◽  
Normal Thyroid ◽  
Stromal Component ◽  
Correlation Parameters

In spite of a considerable efficacy of conservative treatment of goiter, surgery remains the main method of treatment of such patients. Though, on the one hand, total thyroidectomy inevitably results in the development of postsurgical hypothyroidism, on the other hand – in case organ-saving surgery is performed the risk of postsurgical relapse arises. Modern morphological methods are directed to detection of oncological risk of nodular formations, and recommendations concerning an adequate volume of surgery taking into account probability of relapse are practically lacking. Therefore, the objective of the study was finding criteria of a relapsing risk by means of investigation of morphological peculiarities of the parenchymal-stromal correlations in the thyroid gland with recurrent nodular and primary nodular (multinodular) goiter without signs of functional disorders. In the course of the research according to the examined correlation parameters of the parenchyma and stroma various forms of nodular goiter were found to differ from the thyroid tissue without pathological changes by a number of parameters. In particular, specific weight of the parenchyma on an average increases reliably in the tissue of nodular goiter with its various variants in comparison with the thyroid gland without pathological changes. Together with the increase of the parenchymal specific weight in nodular goiter the amount of colloid on an average decreases, and a specific dependence on the kind of goiter is observed – colloid volume decreases from goiter with slow growth to goiter with quick growth, and it is the smallest with goiter relapse. Quantitative analysis of the goiter tissue stromal component demonstrates a considerable increase of its specific volume in comparison with normal thyroid tissue. Evaluation of changes of the morphometric parameters in the thyroid follicles found that in case of nodular goiter with slow growth the percentage of follicles with colloid is close to 100%. On an average it does not differ from that of the normal thyroid tissue. At the same time, in case of nodular goiter with quick growth the percentage of follicles with colloid decreases sharply, and in case of relapse it appears to be still less than that in nodular goiter with quick growth. Besides, with nodular goiter the diameter of follicles on an average increases in comparison with the normal thyroid tissue. In a number of cases it can be estimated as macrofollicular goiter. At the same time, the diameter of follicles is smaller in nodular goiter with quick growth. It is still less in case of goiter relapse. The size of follicles becomes sharply diverse in case of nodular goiter with slow growth, but it decreases in case of nodular goiter with quick growth and relapse. Consequently, recurrent nodular goiter is mostly similar to that of primary nodular goiter with a quick growth, though certain differences between them exist. The peculiarities found enable to suggest that nodular goiter with a quick growth possesses more chances for relapse.

scholarly journals Diagnostic reliability of combined physical examination, mammography, and fine-needle puncture (“triple-test”) in breast tumors: A prospective study

Cancer ◽  
1987 ◽  
Vol 60 (8) ◽  
pp. 1866-1871 ◽  
Author(s):  
Christian Hermansen ◽  
Hans Skovgaard Poulsen ◽  
Jørn Jensen ◽  
Bent Langfeldt ◽  
Verner Steenskov ◽  
...  
Keyword(s):  
Physical Examination ◽  
Prospective Study ◽  
Breast Tumors ◽  
Needle Puncture ◽  
Diagnostic Reliability ◽  
Fine Needle ◽  
Triple Test ◽  
A Prospective Study ◽  
Fine Needle Puncture

Cervical thyroid remnant consistent with papillary carcinoma as an incidental finding in a patient with benign total thyroidectomy ten years prior

2019 ◽  
Vol 91 (4) ◽  
pp. 1-3
Author(s):  
Adriana Ruano Campos ◽  
Daniel Rivera Alonso ◽  
Santiago Ochagavía Cámara
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Papillary Carcinoma ◽  
Cervical Lesion ◽  
Needle Puncture ◽  
Papillary Thyroid ◽  
Thyroid Remnant ◽  
Fine Needle ◽  
Fine Needle Puncture

Background: Differential diagnosis of a cervical lesion corresponding with papillary thyroid carcinoma (PTC) after benign total thyroidectomy can be a real challenge. Methods: A cervical thyroid remnant compatible with papillary carcinoma was incidentally found ten years after total thyroidectomy for a non-functional multinodular goitre. Histological analysis of fine needle puncture aspiration (FNPA) was highly suggestive for PTC. Surgical excision of the cervical lesion was performed. Specimen study demonstrated a classic variant of PTC contacting a peripheral margin, applying ablative treatment with radioactive iodine postoperatively. Results: The patient did not present signs of recurrence during follow-up. Small thyroid remnants after benign thyroidectomy are often left behind, although their risk of malignancy is exceptional. Conclusions: It is important to individualize therapeutic approach when facing this rare entity. We decided to treat the patient by removing the lesion followed by ablation therapy with successful results. PTC: Papillary thyroid carcinoma FNPA: Fine needle puncture aspiration

scholarly journals Pressure of intraoesophageal varices assessed by fine needle puncture: its relation to endoscopic signs and severity of liver disease in patients with cirrhosis.

Gut ◽  
1989 ◽  
Vol 30 (2) ◽  
pp. 228-232 ◽  
Author(s):  
G Kleber ◽  
T Sauerbruch ◽  
G Fischer ◽  
G Paumgartner
Keyword(s):  
Liver Disease ◽  
Needle Puncture ◽  
Fine Needle ◽  
Fine Needle Puncture

Diagnostic fine-needle puncture of the gallbladder.

Radiology ◽  
1991 ◽  
Vol 180 (2) ◽  
pp. 586-586 ◽  
Author(s):  
J Herbetko ◽  
J S Fache
Keyword(s):  
Needle Puncture ◽  
Fine Needle ◽  
Fine Needle Puncture

Ultrasound-guided percutaneous fine needle puncture of the gallbladder for studies of bile composition

1995 ◽  
Vol 68 (807) ◽  
pp. 271-276 ◽  
Author(s):  
S H Hussaini ◽  
C Kennedy ◽  
S P Pereira ◽  
J A H Wass ◽  
R H Dowling
Keyword(s):  
Needle Puncture ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Bile Composition ◽  
Fine Needle Puncture

Evaluation of Pancreatic Tissue Fluid Pressure Measurements Intraoperatively and by Sonographically Guided Fine-Needle Puncture

1990 ◽  
Vol 25 (11) ◽  
pp. 1097-1102 ◽  
Author(s):  
N. Ebbehøj ◽  
L. Borly ◽  
J. Bülow ◽  
J. H. Henriksen ◽  
K. J. Heyeraas ◽  
...  
Keyword(s):  
Fluid Pressure ◽  
Pancreatic Tissue ◽  
Tissue Fluid ◽  
Pressure Measurements ◽  
Needle Puncture ◽  
Fine Needle ◽  
Fine Needle Puncture
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