The role of correction of hypogonadism in the treatment and prophylaxis of urolithiasis in the men presenting with metabolic syndrome

2015 ◽  
Vol 61 (2) ◽  
pp. 12-20
Author(s):  
D A Gusakova ◽  
S Yu Kalinchenko ◽  
A A Kamalov ◽  
Yu A Tishova
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
The Body ◽  
Magnesium Concentration ◽  
Urine Ph ◽  
Testosterone Therapy ◽  
Serum Uric Acid Concentration ◽  
Group 1

Abdominal obesity is a major component of metabolic syndrome (MS) considered to be the key factor contributing to the development of testosterone deficiency (hypogonadism) in men. Bearing in mind the etiopathogenetic relationship between MS and urolithiasis (UL), the present study was undertaken for the purpose of elucidating the role of the main biochemical risk factors of metabolic syndrome in men, evaluating the influence of correction of hypogonadism on these factors, and optimization of the treatment and prevention of MS in these patients. The study included 90 men presenting with hypogonadism in whom the serum levels and renal excretion of the main lithogenic substances (uric acid, calcium, phosphates, magnesium) and urine pH were measured. At the first stage of the study, the patients were allocated to two groups. Group 1 was comprised of 52 patients with UL, group 2 consisted of 38 patients without UL. The patients of group 1 were found to suffer hyperuricemia (the serum uric acid levels 430 mcmol/l and higher). The patients of both groups exhibited hyperuricosuria (daily uric acid excretion over 4.13 mmol/24 hr) with the urine pH value of 5.5 and lower. The serum uric acid concentration was shown to positively correlate with the insulin and C-peptide levels. At the second stage of the study, 65 randomly selected patients were divided into two groups in one of which (n=40) they were given testosterone therapy. Compensation of hypogonadism in these patients was associated with a significant reduction of the serum uric acid levels and its daily excretion, an increase and normalization of urine pH, and a rise in the serum magnesium concentration, Similar significant changes of the same parameters were absent in the control subjects (n=25). Moreover, testosterone therapy improved characteristics of lipid and carbohydrate metabolism, caused reduction in the body weight, BMI, and the severity of insulin resistance.

scholarly journals Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Anna Masajtis-Zagajewska ◽  
Jacek Majer ◽  
Michał Nowicki
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Antihypertensive Drugs ◽  
Uric Acid Concentration ◽  
Urine Excretion ◽  
At1 Receptor Antagonists ◽  
Serum Uric Acid Concentration ◽  
Neutral Effect

Introduction. Excessive intake of fructose increases serum uric acid concentration. Hyperuricemia induces a negative effect on atherosclerosis and inflammation. Hyperuricemia is common in patients with arterial hypertension. Several antihypertensive drugs including diuretics increase serum uric acid concentration. In contrast, the angiotensin II receptor antagonist (ARB) losartan was found to lower serum uric acid though it may increase renal excretion while other ARBs showed mostly a neutral effect. In this study, effects of two AT1 receptor antagonists losartan and eprosartan on serum uric acid changes induced by oral fructose load were directly compared. Methods. The randomized, crossover, head-to-head comparative study comprised 16 ambulatory patients (mean age 64.5 ± 9.8 years). The patients fulfilled AHA/NHLBI 2005 criteria of metabolic syndrome. A daily single morning dose of each study drug (50 mg of losartan or 600 mg of eprosartan) was given during two 3-month periods in a random order separated by 2-week washout time. The oral fructose tolerance test (OFTT) was performed at baseline and after each two 3-onth treatment periods. Before and during OFTT, urine excretion of uric acid and creatinine was assessed in the first morning portion of urine. Blood samples for the measurement of serum uric acid and lipids were taken at baseline and 30, 60, and 120 minutes after oral intake of 75 g of fructose. Results. After 3-month treatment with eprosartan and losartan, both systolic and diastolic blood pressure decreased significantly and to a similar extent. After the treatment, serum uric acid and its baseline and postfructose urine excretion were unchanged. No significant changes of plasma lipids before and after OFTT were observed throughout the study. Conclusions. The study showed that in patients with hypertension and metabolic syndrome, both losartan and eprosartan have a neutral effect on fasting and postfructose load serum uric acid concentration and its urinary excretion. This trial is registered with NCT04954560.

scholarly journals Relationship Between Serum Uric Acid Concentration and Insulin Resistance and Metabolic Syndrome

2005 ◽  
Vol 69 (8) ◽  
pp. 928-933 ◽  
Author(s):  
Tae Woo Yoo ◽  
Ki Chul Sung ◽  
Hun Sub Shin ◽  
Byung Jin Kim ◽  
Bum Soo Kim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration

scholarly journals Effects of Highly Oxygenated Water in a Hyperuricemia Rat Model

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Chih-Hsiang Fang ◽  
Cheng-Chia Tsai ◽  
Yan-Jye Shyong ◽  
Chun-Ting Yang ◽  
Keng-Yuan Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Metabolism ◽  
The Body ◽  
Oxygen Absorption ◽  
Rate Of Increase ◽  
Serum Uric Acid Concentration ◽  
Oxygenated Water ◽  
Oxonic Acid ◽  
Oxygen Concentrations

Recent years have seen a rapidly rising number of oxygenated water brands that claim to impart health benefits and increase athletic performance by improving oxygen availability in the body. Drinks with higher dissolved oxygen concentrations have in recent times gained popularity as potential ergogenic aids, despite the lack of evidence regarding their efficacy. The aim of this study was to characterize oxygenated water and assess the improvement in uric acid metabolism while identifying performance enhancements in animals administered oxygenated water. Oxygenated water was characterized by hydrogen and oxygen nuclear magnetic resonance (NMR) spectroscopy. Hyperuricemia in rats was induced by treatment with oxonic acid potassium salt, and the animals were given oxygenated drinking water before, during, or after oxonic acid treatment. Serum uric acid was measured to confirm the effects on uric acid metabolism. Following oxygenation, the full width at half maximum (FWHM) was reduced to 11.56 Hz and 64.16 Hz in the hydrogen and oxygen NMR spectra, respectively. Oxygenated water molecule clusters were reduced in size due to the reduction in FWHM. Oxygen concentration did not vary significantly with increased temperature. However, standing time played a critical role in the amount of oxygen dissolved in the water. The rat studies indicated that oxygenated water reduced serum uric acid levels and their rate of increase and enhanced uric acid metabolism. A significant improvement in uric acid metabolism and rate of increase in serum uric acid concentration was observed in hyperuricemic rats administered oxygenated water compared to that in rats administered regular water. High oxygen concentrations enhanced the rate of oxygen absorption, leading to increased glycolysis and mitochondrial protein synthesis. Therefore, oxygenated water is a potential adjuvant therapy or health food for treatment of hyperuricemia.

A possible role of serum uric acid as a marker of metabolic syndrome

2014 ◽  
Vol 44 (12a) ◽  
pp. 1210-1216 ◽  
Author(s):  
Y.-J. Lee ◽  
S. Cho ◽  
S. R. Kim
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid

Low serum uric acid concentration augments insulin effects on the prevalence of metabolic syndrome

2018 ◽  
Vol 12 (3) ◽  
pp. 325-331 ◽  
Author(s):  
Leonardo M. Porchia ◽  
M. Elba Gonzalez-Mejia ◽  
Enrique Torres-Rasgado ◽  
Guadalupe Ruiz-Vivanco ◽  
Ricardo Pérez-Fuentes
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration ◽  
Low Serum

Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid

Metabolism ◽  
2007 ◽  
Vol 56 (6) ◽  
pp. 751-756 ◽  
Author(s):  
Jen-Der Lin ◽  
Wen-Ko Chiou ◽  
Hung-Yu Chang ◽  
Feng-Hsuan Liu ◽  
Hsiao-Fen Weng
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid
Sign in / Sign up

Export Citation Format

Share Document