scholarly journals Endometrial cell apoptosis impairment associated with hormonal imbalance as a key factor in the development of endometriosis

2019 ◽  
Vol 65 (2) ◽  
pp. 140-144
Author(s):  
Roman V. Ukrainets ◽  
Yulia S. Korneva
Keyword(s):  
Abdominal Cavity ◽  
Gonadotropin Releasing Hormone ◽  
Endometrial Tissue ◽  
Apoptotic Pathway ◽  
Releasing Hormone ◽  
Endometrial Cells ◽  
Key Factor ◽  
Apoptotic Pathways ◽  
Nuclear Estrogen Receptor

The review describes the effect of certain hormones and their imbalance on apoptosis of retrogradely refluxed endometrial cells in the abdominal cavity and the effects of estrogen, progesterone, anti-Mullerian hormone, and gonadotropin-releasing hormone on the internal and external apoptotic pathways of various cell populations in endometriotic foci. The nuclear estrogen receptor (ER-) is shown to inhibit TNF receptors that trigger the external apoptotic pathway, but the effects of estrogens do not play a key role in the pathogenesis of endometriosis. The role of progesterone and changes in the receptor status towards prevalence of PR-A with a decreased response of endometrial tissue to progesterone and inhibition of apoptosis are described. We discuss the role of the anti-Mllerian hormone and gonadotropin-releasing hormone II (GnRH II) as activators of apoptosis in normal endometrial tissue and in endometriosis. Investigation of endocrine effects on apoptosis of parenchymal and stromal cells of endometriotic foci may provide a theoretical basis for searching for new therapeutic targets in this hormone-dependent pathology.

scholarly journals Stimulation of Gonadotropin-Releasing Hormone Surges by Estrogen. II. Role of Cyclic Adenosine 3′,5′-Monophosphate

Endocrinology ◽  
2000 ◽  
Vol 141 (4) ◽  
pp. 1486-1492 ◽  
Author(s):  
Patrick E. Chappell ◽  
Juliet Lee ◽  
Jon E. Levine
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Stimulation Of

Ovarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage **Partially supported by Fonds de la Recherche Scientifique grant 3.4587.90, Brussels, Belgium.

1994 ◽  
Vol 62 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Jacques Donnez ◽  
Michelle Nisolle ◽  
Stephane Gillerot ◽  
Vincent Anaf ◽  
Françoise Clerckx-Braun ◽  
...  
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Agonist

Role of Gonadotropin-Releasing Hormone Analog in the Management of Male Metastatic Breast Cancer Is Uncertain

2007 ◽  
Vol 25 (24) ◽  
pp. 3787-3787 ◽  
Author(s):  
Nan Soon Wong ◽  
Wei Seong Ooi ◽  
Kathleen I. Pritchard
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Hormone Analog

scholarly journals Role of Kisspeptin in Puberty in Humans

2020 ◽  
pp. 92-97
Author(s):  
Ravi Kant ◽  
Mahendra Kumar Meena
Keyword(s):  
Reproductive Biology ◽  
Conventional Treatment ◽  
Hypogonadotropic Hypogonadism ◽  
Follicle Stimulating Hormone ◽  
Gonadotropin Releasing Hormone ◽  
Pilot Studies ◽  
Releasing Hormone ◽  
Infertile Couples ◽  
Stimulating Hormone

Kisspeptin or GPR-54 is a product of KISS 1 gene regulating the production of gonadotropin releasing hormone (GnRH), luteinizing (LH) as well follicle stimulating hormone (FSH). Both LH and FSH are important hormones for reproduction in animals as well in humans. The recognition of Kisspeptin has a landmark bearing in reproductive biology. Few recent pilot studies have convincingly proven it to be a promising molecule in treating infertile couples especially those having hypogonadotropic hypogonadism not responding to conventional treatment.

scholarly journals Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences

2020 ◽  
Vol 21 (2) ◽  
pp. 529 ◽  
Author(s):  
Klaudia Barabás ◽  
Edina Szabó-Meleg ◽  
István M. Ábrahám
Keyword(s):  
Suppressive Effect ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Inflammatory Signals ◽  
Cholinergic Pathway ◽  
Gnrh Neurons ◽  
Functional Consequences ◽  
Anti Inflammatory ◽  
The Impact

Inflammation has a well-known suppressive effect on fertility. The function of gonadotropin-releasing hormone (GnRH) neurons, the central regulator of fertility is substantially altered during inflammation in females. In our review we discuss the latest results on how the function of GnRH neurons is modified by inflammation in females. We first address the various effects of inflammation on GnRH neurons and their functional consequences. Second, we survey the possible mechanisms underlying the inflammation-induced actions on GnRH neurons. The role of several factors will be discerned in transmitting inflammatory signals to the GnRH neurons: cytokines, kisspeptin, RFamide-related peptides, estradiol and the anti-inflammatory cholinergic pathway. Since aging and obesity are both characterized by reproductive decline our review also focuses on the mechanisms and pathophysiological consequences of the impact of inflammation on GnRH neurons in aging and obesity.

Extending the use of gonadotropin-releasing hormone agonists: the emerging role of steroidal and nonsteroidal agents

1994 ◽  
Vol 61 (1) ◽  
pp. 21-34 ◽  
Author(s):  
Eli Y. Adashi ◽  
André Lemay ◽  
Eric S. Surrey ◽  
Andrew J. Friedman
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone

Role of Aspartate7.32(302) of the Human Gonadotropin-Releasing Hormone Receptor in Stabilizing a High-Affinity Ligand Conformation

2001 ◽  
Vol 60 (6) ◽  
pp. 1280-1287 ◽  
Author(s):  
Bernhard J. Fromme ◽  
Arieh A. Katz ◽  
Roger W. Roeske ◽  
Robert P. Millar ◽  
Colleen A. Flanagan
Keyword(s):  
Hormone Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
High Affinity ◽  
Affinity Ligand ◽  
Ligand Conformation ◽  
Gonadotropin Releasing Hormone Receptor ◽  
High Affinity Ligand
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