scholarly journals PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Fangnan Wu ◽  
Chaolu Huder ◽  
Zhenjun Tian
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Intervention Group ◽  
Tail Suspension Test ◽  
Serum Testosterone ◽  
Chronic Fatigue ◽  
Forced Swimming ◽  
Control Group ◽  
Stress System ◽  
Fatigue Syndrome ◽  
Antioxidant Stress

Objective To investigate the effects of exogenous VD3 on exercise-induced chronic fatigue syndrome (CFS) and its mechanism. Methods 80 male mice were randomly divided into 5 groups（n=16）. One group was named as quiet control group (C) while the other four were used to build CFS model by forced swimming. Among the four groups, three were selected for feeding VD3 1 h before exercise (bVD), 15 min after starting exercise (mVD) and 1 h after exercise (aVD) respectively, and the group without VD3 feeding was CFS model group (CFS). The behavior and condition of mice was observed during the whole process. After the training was completed totally, the tail suspension test and the forced swimming test were implemented, and then the blood and quadriceps were dissected. Serum testosterone and corticosterone content, as well as the antioxidant system indexes in the quadriceps, including malondialdehyde (MDA), total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX) and total superoxide dismutase (T-SOD), were measured. Routine western blotting experimentation was used to measure signal pathway indicators, containing SIRT1, SIRT3, ERK1/2, p-ERK1/2 and MEK1/2. Results Compared with C group, CFS group appeared serious damage caused by fighting, and the concentration of serum testosterone decreased significantly (p<0.01 or p<0.05) while cortisol concentration increased significantly (p<0.01 or p<0.05). Regarding antioxidant stress system indexes, the expression of MDA, T-SOD and GSH-PX significantly increased (p<0.05). The concentration of MEK and SIRT3 decreased significantly (p<0.01 or p<0.05). Compared with CFS group, VD intervention group (bVD, mVD and aVD) showed less damage caused by fighting and significantly lighter body weight (p<0.05), and the concentration of serum testosterone increased significantly (p<0.05) while that of cortisol decreased significantly (p<0.01 or p<0.05). The expression of MDA decreased significantly (p<0.05), on the countrary, T-AOC, T-SOD and GSH-PX increased significantly (p<0.05). The expressions of MEK, p-ERK/ERK, SIRT1 and SIRT3 were significantly upregulated (p<0.01 or p<0.05). Conclusions Exogenous VD3 could alleviate CFS, which probably related to activate the MEKs/ERKs-SIRT1 signal transduction axis and hence regulate the expression of SIRT3.

scholarly journals Effect of Mindfulness Sessions on Chronic Fatigue Syndrome and Job Satisfaction of Nurses: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Nasrin Bonakdari ◽  
Nadereh Mohammadi ◽  
Mohammad Reza Taghvizadeh Yazdi ◽  
Reza Norouzadeh ◽  
Mohammad Abbasinia ◽  
...  
Keyword(s):  
Job Satisfaction ◽  
Clinical Trial ◽  
Chronic Fatigue Syndrome ◽  
Randomized Clinical Trial ◽  
Intervention Group ◽  
Clinical Trial Design ◽  
Well Being ◽  
Chronic Fatigue ◽  
Control Group ◽  
Fatigue Syndrome

Abstract Background: Nursing is considered a stressful profession, so nurses are at higher risk of physical and mental illness. Mindfulness is an important concept for nursing with practical implications for nurse well-being, development, and quality nursing care sustainability.Objectives: This study identified mindfulness sessions' effect on nurses' chronic fatigue syndrome(CFS) and job satisfaction )JS.(Methods: A randomized clinical trial design was conducted on 80 nurses to intervention and control groups. The intervention in the intervention group was eight mindfulness sessions training, and the control group had no intervention. Nurses' CFS and JS were assessed using the Minnesota Satisfaction Questionnaire and The Multidimensional Fatigue Inventory.Results: After implementing a mindfulness-based stress reduction program, the intervention group nurses reported lower CFS and higher JS than the control group(p<0.005). Conclusion: The findings of this study indicate the effectiveness of mindfulness programs on improving nurses' chronic fatigue and JS. Since CFS and job dissatisfaction are two disturbing elements for nurses' optimal performance in professional and personal life, this study can recommend the implementation of mindfulness exercises as a routine, operational and uncomplicated program in nurses.

scholarly journals Effects of Qigong Exercise on Fatigue, Anxiety, and Depressive Symptoms of Patients with Chronic Fatigue Syndrome-Like Illness: A Randomized Controlled Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Jessie S. M. Chan ◽  
Rainbow T. H. Ho ◽  
Chong-wen Wang ◽  
Lai Ping Yuen ◽  
Jonathan S. T. Sham ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Chronic Fatigue Syndrome ◽  
Controlled Trial ◽  
Alternative Therapy ◽  
Intervention Group ◽  
Chronic Fatigue ◽  
Control Group ◽  
Complementary And Alternative Therapy ◽  
Fatigue Score ◽  
Fatigue Syndrome

Background. Anxiety/depressive symptoms are common in patients with chronic fatigue syndrome- (CFS-) like illness. Qigong as a modality of complementary and alternative therapy has been increasingly applied by patients with chronic illnesses, but little is known about the effect of Qigong on anxiety/depressive symptoms of the patients with CFS-like illness.Purpose. To investigate the effects of Qigong on fatigue, anxiety, and depressive symptoms in patients with CFS-illness.Methods. One hundred and thirty-seven participants who met the diagnostic criteria for CFS-like illness were randomly assigned to either an intervention group or a waitlist control group. Participants in the intervention group received 10 sessions of Qigong training twice a week for 5 consecutive weeks, followed by home-based practice for 12 weeks. Fatigue, anxiety, and depressive symptoms were assessed at baseline and postintervention.Results. Total fatigue score [F1,135=13.888,P<0.001], physical fatigue score [F1,135=20.852,P<0.001] and depression score [F1,135=9.918,P=0.002] were significantly improved and mental fatigue score [F1,135=3.902,P=0.050] was marginally significantly improved in the Qigong group compared to controls. The anxiety score was not significantly improved in the Qigong group.Conclusion. Qigong may not only reduce the fatigue symptoms, but also has antidepressive effect for patients with CFS-like illness. Trial registrationHKCTR-1200.

scholarly journals From Body to Mind and Spirit: Qigong Exercise for Bereaved Persons with Chronic Fatigue Syndrome-Like Illness

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Jie Li ◽  
Jessie S. M. Chan ◽  
Amy Y. M. Chow ◽  
Lai Ping Yuen ◽  
Cecilia L. W. Chan
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Intervention Group ◽  
Well Being ◽  
Chronic Fatigue ◽  
Mental Fatigue ◽  
Control Group ◽  
Random Group ◽  
Fatigue Syndrome ◽  
Spiritual Well Being ◽  
Negative Impacts

Bereavement may bring negative impacts on the mind, body, and spiritual well-being of grieving persons. Some bereaved persons with chronic fatigue syndrome- (CFS-) illness experience a dual burden of distress. This study investigated the effects of bereavement on CFS-like illness by comparing bereaved and nonbereaved participants. It also adopted a random group design to investigate the effectiveness of Qigong on improving the well-being of bereaved participants. The Qigong intervention comprised 10 group sessions delivered twice a week for 5 weeks and home-practice for at least three times a week lasting 15–30 minutes each. The participants’ fatigue, anxiety, and depression, quality of life (QoL), and spiritual well-being were measured at baseline and 3 months after treatment. The bereaved participants experienced significantly greater mental fatigue (16.09 versus 14.44,p=0.017) and lower physical QoL (34.02 versus 37.17,p=0.011) than their nonbereaved counterparts. After 3 months, the mental fatigue (−8 versus −4,p=0.010) and physical fatigue (−10 versus −5,p=0.007) experienced by intervention group had declined significantly, and improvements on their spirituality (14 versus −2,p=0.013) and psychological QoL (8.91 versus 0.69,p=0.002) scores exceeded those of the control group.

scholarly journals Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case–control study

2003 ◽  
Vol 33 (7) ◽  
pp. 1185-1192 ◽  
Author(s):  
SIMON HATCHER ◽  
ALLAN HOUSE
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Life Events ◽  
Stressful Life Events ◽  
Chronic Fatigue ◽  
Case Control ◽  
Stressful Events ◽  
Control Group ◽  
Liaison Psychiatry ◽  
Fatigue Syndrome

Background. The role of stress in the onset of chronic fatigue syndrome is unclear. Our objectives in this study were first, to determine the relation between the onset of chronic fatigue syndrome and stressful life events and difficulties. Secondly, we examined the role of a particular type of problem, dilemmas, in the onset of chronic fatigue syndrome.Method. We used a case–control design with 64 consecutive referrals from an Infectious Diseases/Liaison Psychiatry Fatigue clinic and 64 age- and sex-matched controls from a general practice population control group in Leeds. We had two main outcome measures; the odds ratios of the risk of developing chronic fatigue syndrome after experiencing a severe life event, severe difficulties or both in the year and 3 months preceding onset; and the proportion of subjects in each group who experienced a dilemma prior to onset.Results. Patients with chronic fatigue syndrome were more likely to experience severe events and difficulties in the 3 months (OR=9, 95% CI 3·2 to 25·1) and year (OR=4·3, 95% CI 1·8 to 10·2) prior to onset of their illness than population controls. In the 3 months prior to onset 19 of the 64 patients (30%) experienced a dilemma compared to none of the controls.Conclusions. Chronic fatigue syndrome is associated with stressful events and difficulties prior to onset. Those events and difficulties characterized as being dilemmas seem to be particularly important.

scholarly journals Chronic fatigue syndrome: a clinical and laboratory study with a well matched control group

1995 ◽  
Vol 237 (5) ◽  
pp. 499-506 ◽  
Author(s):  
CAROLINE M. A. SWANINK ◽  
JAN H. M. M. VERCOULEN ◽  
GIJS BLEIJENBERG ◽  
JAN F. M. FENNIS ◽  
JOEP M. D. GALAMA ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Laboratory Study ◽  
Matched Control ◽  
Chronic Fatigue ◽  
Control Group ◽  
Matched Control Group ◽  
Fatigue Syndrome

Chronic fatigue syndrome

2007 ◽  
Vol 278 ◽  
pp. 1-3
Keyword(s):  
Clinical Trial ◽  
Amino Acids ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
The Body ◽  
Firm Conclusion ◽  
Fatigue Syndrome ◽  
Clinical Trial Evidence ◽  
Antioxidant Stress ◽  
Trial Evidence

In a nutshellVarious nutrition links have been proposed for CFS. The most likely to have some validity are an imbalance of LCPFA, or of amino acids and the neurotransmitters synthesised from them. There may be some antioxidant stress involved as well.Unfortunately, the body of clinical trial evidence does not add up to any firm conclusion, despite the popularity of nutritional treatments amongst CFS patients.

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