Dependence of Shape and Geometry of Microelectrodes in Manipulating Polarizable Particles like DNA through Electro-kinetic Effects

2016 ◽  
Vol 66 (4) ◽  
pp. 307 ◽  
Author(s):  
Sudarshan Ghonge ◽  
Souri Banerjee

<p>Recently electro-kinetics, namely AC electro-osmosis and dielectrophoresis have been judiciously utilised to manipulate movement of polarizable particles like DNA suspended in aqueous solution and placed between electrically fed microelectrodes. Researchers around the globe have tried to fabricate electrodes of different geometries to understand how electric field owing to sharpness of the electrodes has influenced the aforementioned electro-kinetic properties. In this review, we have presented a chronological development indesign of patterned electrodes used to align and trap DNA molecules in and around the electrodes. We have examined the pros and the cons of such geometry of the set of the micro-electrodes and also tried to provide a solution in terms of shape and sharpness of the electrode that would facilitate DNA molecules to bridge between the electrodes for further application of conducting DNA as molecular wire. </p>

2021 ◽  
Author(s):  
Jagdish Bhatt

An external electric field can induce mechanical changes depending on the amplitude, frequency and duration of the applied electric field. This study is focused on monitoring the electric/electro-kinetic effects of real biological tissues (in vitro) and gelatin phantoms with high spatial resolution. In this study, we investigated the mean of the signal spectrum at the modulation frequency, root-mean-square of the noise in the spectrum, and signal-to-noise ratio (SNR) during the application of low-frequency AC electric field in tissues and phantoms. Our results show that the EIMC SNR can indicate the existence of AC electric current in samples, rather than be directly related to the sample's electro-kinetic properties of the samples. We also found that the SNR varies spatially even for homogenous samples. These two features might hinder the development of the proposed method to be a viable clinical diagnostic technique.


2021 ◽  
Author(s):  
Jagdish Bhatt

An external electric field can induce mechanical changes depending on the amplitude, frequency and duration of the applied electric field. This study is focused on monitoring the electric/electro-kinetic effects of real biological tissues (in vitro) and gelatin phantoms with high spatial resolution. In this study, we investigated the mean of the signal spectrum at the modulation frequency, root-mean-square of the noise in the spectrum, and signal-to-noise ratio (SNR) during the application of low-frequency AC electric field in tissues and phantoms. Our results show that the EIMC SNR can indicate the existence of AC electric current in samples, rather than be directly related to the sample's electro-kinetic properties of the samples. We also found that the SNR varies spatially even for homogenous samples. These two features might hinder the development of the proposed method to be a viable clinical diagnostic technique.


2015 ◽  
Vol 17 (3) ◽  
pp. 2235-2240 ◽  
Author(s):  
Irena Reytblat ◽  
Keren Keinan-Adamsky ◽  
Jordan H. Chill ◽  
Hugo E. Gottlieb ◽  
Aharon Gedanken ◽  
...  

DNA molecules were recently converted using ultrasonic irradiation into microcapsules that can trap hydrophobic molecules in aqueous solution.


1985 ◽  
Vol 107 ◽  
pp. 381-389
Author(s):  
Akira Hasegawa

Mechanisms of Alfvén wave heating in space-astrophysical plasmas are presented with particular emphasis on the parallel electric field generated in the magnetohydrodynamic perturbations due to the finite Larmor radius effects.


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