This study presents the possibility of control of nanofluidics in the bio-inspired nanosized ion channel using a field effect transistor (FET) structure. We analyzed effects from main dominant factors to control the ion flow in nanosized channel such as electro-osmosis, diffusion effect, Coulomb force between ions and pressure force. Additionally, we suggest a strategy to control the ion flow accurately at the specific position in the nanochannel by handling the viscosity, ion molecular density, pressure, gate and trans-cis voltages of FET structure.