scholarly journals Intradiscal Delivery of Anabolic Growth Factors and a Metalloproteinase Inhibitor in a Rabbit Acute Lumbar Disc Injury Model

10.14444/7078 ◽  
2020 ◽  
Vol 14 (4) ◽  
pp. 585-593
Author(s):  
SAPAN D. GANDHI ◽  
TRISTAN MAERZ ◽  
SEAN MITCHELL ◽  
CASEY BACHISON ◽  
DANIEL K. PARK ◽  
...  
Keyword(s):  
Growth Factors ◽  
Lumbar Disc ◽  
Metalloproteinase Inhibitor ◽  
Injury Model ◽  
Disc Injury

Point of View: A Familial Predisposition Toward Lumbar Disc Injury

Spine ◽  
1997 ◽  
Vol 22 (13) ◽  
pp. 1493
Author(s):  
Mark G. Miller
Keyword(s):  
Lumbar Disc ◽  
Point Of View ◽  
Familial Predisposition ◽  
Disc Injury

scholarly journals Radiological, Histological and Biochemical Characterization of a Novel Ovine Lumbar Intervertebral Disc Injury Model

2016 ◽  
Vol 6 (1_suppl) ◽  
pp. s-0036-1582625-s-0036-1582625
Author(s):  
Christopher Daly ◽  
Tony Goldschlager ◽  
Peter Ghosh ◽  
Graham Jenkin ◽  
Justin Cooper-White ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Biochemical Characterization ◽  
Lumbar Intervertebral Disc ◽  
Injury Model ◽  
Disc Injury

Lumbar Disc Injury : A Retrospective Study of 150 cases

2003 ◽  
Vol 32 (112) ◽  
pp. 219-226
Author(s):  
A K Baskota ◽  
S Rajbhandari ◽  
S Rijal
Keyword(s):  
Retrospective Study ◽  
Lumbar Disc ◽  
Disc Injury

Abstract

scholarly journals Effects of Controlled Dual Growth Factor Delivery on Bone Regeneration Following Composite Bone-Muscle Injury

2020 ◽  
Author(s):  
Ramesh Subbiah ◽  
Albert Cheng ◽  
Marissa A. Ruehle ◽  
Marian H. Hettiaratchi ◽  
Luiz E. Bertassoni ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Bone Tissue ◽  
Treatment Strategy ◽  
Growth Factor Delivery ◽  
Treatment Groups ◽  
Vascular Growth ◽  
Injury Model ◽  
Dual Growth Factor Delivery

AbstractThe objective of this study was to investigate the controlled release of two growth factors (BMP-2 and VEGF) as a treatment strategy for clinically challenging composite injuries, consisting of a segmental bone defect and volumetric muscle loss. This is the first investigation of dual growth factor delivery in a composite injury model using an injectable smart delivery system consisting of heparin microparticles and alginate gel. The loading efficiency of growth factors into these biomaterials was found to be >90%, revealing a strong affinity of VEGF and BMP-2 to heparin and alginate. The system could achieve simultaneous or sequential release of VEGF and BMP-2 by varying the loading strategy. Single growth factor delivery (VEGF or BMP-2 alone) significantly enhanced vascular growth in vitro. However, no synergistic effect was observed for dual growth factor (BMP-2 + VEGF) delivery. Effective bone healing was achieved in all treatment groups (BMP-2, simultaneous or sequential delivery of BMP-2 and VEGF) in the composite injury model. The mechanics of the regenerated bone reached a maximum strength of ∼52% of intact bone with sequential delivery of VEGF and BMP-2. Overall, simultaneous or sequential co-delivery of low-dose BMP-2 and VEGF failed to fully restore the mechanics of bone in this injury model. Given the severity of the composite injury, VEGF alone may not be sufficient to establish mature and stable blood vessels when compared with previous studies co-delivering BMP-2+VEGF enhanced bone tissue regeneration. Hence, future studies are warranted to develop an alternative treatment strategy focusing on better control over growth factor dose, spatiotemporal delivery, and additional growth factors to regenerate fully functional bone tissue.HighlightsWe developed a smart growth factor delivery system using heparin microparticles and alginate that facilitates tunable delivery of VEGF and BMP-2 in a simultaneous or sequential manner by merely varying the loading strategy.In vitro, both VEGF and BMP-2 alone promoted vascular growth; however, VEGF was significantly more potent, and there was no detectable benefit of co-delivery.In vivo, both BMP-2 alone and co-delivery of VEGF and BMP-2 promoted bone formation in the challenging bone/muscle polytrauma model; however, none of the treatment groups restored biomechanical properties to that of uninjured bone.

scholarly journals Paraspinal muscle degeneration and regenerative potential in a Murine model of Lumbar Disc Injury

2021 ◽  
Vol 6 ◽  
pp. 100061
Author(s):  
Michael R. Davies ◽  
Gurbani Kaur ◽  
Xuhui Liu ◽  
Francisco Gomez Alvarado ◽  
Prashant Nuthalapati ◽  
...  
Keyword(s):  
Murine Model ◽  
Lumbar Disc ◽  
Paraspinal Muscle ◽  
Muscle Degeneration ◽  
Disc Injury

Lumbar disc injury in the athlete

2002 ◽  
Vol 21 (1) ◽  
pp. 147-165 ◽  
Author(s):  
Robert G Watkins
Keyword(s):  
Lumbar Disc ◽  
Disc Injury

scholarly journals Histological Features of the Degenerating Intervertebral Disc in a Goat Disc-Injury Model

Spine ◽  
2011 ◽  
Vol 36 (19) ◽  
pp. 1519-1527 ◽  
Author(s):  
Yejia Zhang ◽  
Susan Drapeau ◽  
Howard S. An ◽  
Dessislava Markova ◽  
Brett A. Lenart ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Histological Features ◽  
Injury Model ◽  
Disc Injury

scholarly journals TNFAIP8 family gene expressions in the mouse tail intervertebral disc injury model

JOR Spine ◽  
2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Zuozhen Tian ◽  
Frances S. Shofer ◽  
Lutian Yao ◽  
Honghong Sun ◽  
Hongtao Zhang ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Gene Expressions ◽  
Injury Model ◽  
Disc Injury ◽  
Family Gene

53. Transplantation of Goat Bone Marrow-Derived Stromal Cells to a Degenerative Intervertebral Disc in a Goat Disc-Injury Model

2009 ◽  
Vol 9 (10) ◽  
pp. 27S
Author(s):  
Yejia Zhang ◽  
Susan Drapeau ◽  
Howard An ◽  
Eugene Thonar ◽  
D. Greg Anderson
Keyword(s):  
Bone Marrow ◽  
Intervertebral Disc ◽  
Stromal Cells ◽  
Injury Model ◽  
Disc Injury

scholarly journals Transplantation of Goat Bone Marrow Stromal Cells to the Degenerating Intervertebral Discin a Goat Disc Injury Model

Spine ◽  
2011 ◽  
Vol 36 (5) ◽  
pp. 372-377 ◽  
Author(s):  
Yejia Zhang ◽  
Susan Drapeau ◽  
S. An Howard ◽  
Eugene J. M. A. Thonar ◽  
D. Greg Anderson
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Injury Model ◽  
Disc Injury
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