Paraspinal muscle degeneration and regenerative potential in a Murine model of Lumbar Disc Injury

Abstract Background The purpose of the study is to investigate the correlation between upper lumbar disc herniation (ULDH) and multifidus muscle degeneration via the comparison of width, the cross-sectional area and degree of fatty infiltration of the lumbar multifidus muscle. Methods Using the axial T2-weighted images of magnetic resonance imaging as an assessment tool, we retrospectively investigated 132 patients with ULDH and 132 healthy individuals. The total muscle cross-sectional area (TMCSA) and the pure muscle cross-sectional area (PMCSA) of the multifidus muscle at the L1/2, L2/3, and L3/4 intervertebral disc levels were measured respectively, and in the meantime, the average multifidus muscle width (AMMW) and degree of fatty infiltration of bilateral multifidus muscle were evaluated. The resulting data were analyzed to determine the presence/absence of statistical significance between the study and control groups. Multivariate logistical regression analyses were used to evaluate the correlation between ULDH and multifidus degeneration. Results The results of the analysis of the two groups showed that there were statistically significant differences (p < 0.05) between TMCSA, PMCSA, AMMW and degree of fatty infiltration. The multivariate logistic regression analysis indicated that the TMCSA, PMCSA, AMMW and the degree of fatty infiltration of multifidus muscle were correlated with ULDH, and the differences were statistically significant (P < 0.05). Conclusions A correlation could exist between multifidus muscles degeneration and ULDH, that may be a process of mutual influence and interaction. Lumbar muscle strengthening training could prevent and improve muscle atrophy and degeneration.

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Relationship between Lumbar Disc Degeneration and Back Muscle Degeneration

Journal of Korean Society of Spine Surgery ◽

10.4184/jkss.2018.25.2.53 ◽

2018 ◽

Vol 25 (2) ◽

pp. 47

Author(s):

Kyung-Sub Song ◽

Seung-Hwan Lee ◽

Byeong-Mun Park ◽

Su-Keon Lee ◽

Moses Lee ◽

...

Keyword(s):

Disc Degeneration ◽

Lumbar Disc ◽

Muscle Degeneration ◽

Lumbar Disc Degeneration ◽

Back Muscle

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The Study of Fat Infiltration Ratio in Lumbar Paraspinal Muscle of Patient with Herniated Intervertebral Lumbar Disc

Journal of the Korea Academia-Industrial cooperation Society ◽

10.5762/kais.2012.13.11.5254 ◽

2012 ◽

Vol 13 (11) ◽

pp. 5254-5260

Author(s):

Bong-Jun Kong ◽

Jung-Ho Lee ◽

Min-Sik Yong ◽

Jin-Sang Kim

Keyword(s):

Lumbar Disc ◽

Paraspinal Muscle ◽

Fat Infiltration

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Point of View: A Familial Predisposition Toward Lumbar Disc Injury

Spine ◽

10.1097/00007632-199707010-00013 ◽

1997 ◽

Vol 22 (13) ◽

pp. 1493

Author(s):

Mark G. Miller

Keyword(s):

Lumbar Disc ◽

Point Of View ◽

Familial Predisposition ◽

Disc Injury

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Lumbar Disc Injury : A Retrospective Study of 150 cases

Journal of Nepal Medical Association ◽

10.31729/jnma.1262 ◽

2003 ◽

Vol 32 (112) ◽

pp. 219-226

Author(s):

A K Baskota ◽

S Rajbhandari ◽

S Rijal

Keyword(s):

Retrospective Study ◽

Lumbar Disc ◽

Disc Injury

Abstract

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Statistical morphological analysis reveals characteristic paraspinal muscle asymmetry in unilateral lumbar disc herniation

Scientific Reports ◽

10.1038/s41598-021-95149-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yiming Xiao ◽

Maryse Fortin ◽

Joshua Ahn ◽

Hassan Rivaz ◽

Terry M. Peters ◽

...

Keyword(s):

Shape Analysis ◽

Disc Herniation ◽

Lumbar Disc ◽

Fatty Infiltration ◽

Erector Spinae ◽

Paraspinal Muscle ◽

Leg Pain ◽

Statistical Shape Analysis ◽

Muscle Morphology ◽

Statistical Shape

AbstractGrowing evidence suggests an association of lumbar paraspinal muscle morphology with low back pain (LBP) and lumbar pathologies. Unilateral spinal disorders provide unique models to study this association, with implications for diagnosis, prognosis, and management. Statistical shape analysis is a technique that can identify signature shape variations related to phenotypes but has never been employed in studying paraspinal muscle morphology. We present the first investigation using this technique to reveal disease-related paraspinal muscle asymmetry, using MRIs of patients with a single posterolateral disc herniation at the L5-S1 spinal level and unilateral leg pain. Statistical shape analysis was conducted to reveal disease- and phenotype-related morphological variations in the multifidus and erector spinae muscles at the level of herniation and the one below. With the analysis, shape variations associated with disc herniation were identified in the multifidus on the painful side at the level below the pathology while no pathology-related asymmetry in cross-sectional area (CSA) and fatty infiltration was found in either muscle. The results demonstrate higher sensitivity and spatial specificity for the technique than typical CSA and fatty infiltration measures. Statistical shape analysis holds promise in studying paraspinal muscle morphology to improve our understanding of LBP and various lumbar pathologies.

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Intradiscal Delivery of Anabolic Growth Factors and a Metalloproteinase Inhibitor in a Rabbit Acute Lumbar Disc Injury Model

The International Journal of Spine Surgery ◽

10.14444/7078 ◽

2020 ◽

Vol 14 (4) ◽

pp. 585-593

Author(s):

SAPAN D. GANDHI ◽

TRISTAN MAERZ ◽

SEAN MITCHELL ◽

CASEY BACHISON ◽

DANIEL K. PARK ◽

...

Keyword(s):

Growth Factors ◽

Lumbar Disc ◽

Metalloproteinase Inhibitor ◽

Injury Model ◽

Disc Injury

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Paraspinal Muscle Degeneration as an Independent Risk for Loss of Local Alignment in Degenerative Lumbar Scoliosis Patients After Corrective Surgery

Global Spine Journal ◽

10.1177/21925682211022284 ◽

2021 ◽

pp. 219256822110222

Author(s):

Gengyu Han ◽

Wei Wang ◽

Siyu Zhou ◽

Wei Li ◽

Bo Zhang ◽

...

Keyword(s):

Paraspinal Muscle ◽

Local Alignment ◽

Global Alignment ◽

Degenerative Lumbar Scoliosis ◽

Muscle Degeneration ◽

Corrective Surgery ◽

Paraspinal Muscles ◽

Lumbar Scoliosis ◽

Maintenance Group

Study Design: Retrospective study. Objectives: To investigate the effect of paraspinal muscle degeneration on the maintenance of local and global alignment among degenerative lumbar scoliosis (DLS) patients after corrective surgery. Methods: 98 DLS patients with a mean follow-up period of 38.3 months after corrective surgery were included. The T1 pelvic angle (TPA), lumbar lordosis (LL), pelvic incidence were measured preoperatively, immediate postoperatively and at last follow-up. All patients were divided into LL maintenance group (n = 21) and LL loss group (n = 77). For patients with well-aligned correction (immediate postoperative TPA ≤ 20°, n = 73), they were divided into TPA maintenance group (last follow-up TPA ≤ 20°) and TPA loss group (last follow-up TPA > 20°). The relative gross cross-sectional area (rGCSA) and fat infiltration (FI) of multifidus (MF) and erector spinae (ES), and the relative functional CSA (rFCSA) of psoas major (PS) were measured at L3, L4 and L5 on preoperative magnetic resonance imaging. Results: MF rGCSA were significantly smaller in LL loss group than in LL maintenance group. Both MF rGCSA and PS rFCSA were significantly smaller and MF FI was significantly higher in TPA loss group than in TPA maintenance group. Binary logistic regression revealed that the MF rGCSA was an independent factor of LL loss; Large immediate postoperative TPA was an independent risk factor of TPA loss, but not the parameters of paraspinal muscles. Conclusion: The effect of paraspinal muscles in lower lumbar segments might be mainly focused on the maintenance of local alignment rather than the global alignment.

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