scholarly journals Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy

2017 ◽  
Vol 37 (6) ◽  
pp. 458-466
Author(s):  
G. Cadoni ◽  
L. Giraldi ◽  
L. Petrelli ◽  
M. Pandolfini ◽  
M. Giuliani ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Retrospective Analysis ◽  
Neck Cancer ◽  
Hazard Ratio ◽  
Single Institution

È stata condotta un’analisi retrospettiva su 482 pazienti con diagnosi di tumore testa-collo arruolati presso l’ ospedale “Agostino Gemelli” di Roma. L’associazione tra fattori demografici, clinici e comportamentali con la overall survival (OS), il rischio di ricorrenza ed il rischio di un secondo tumore primitivo è stata stimata usando gli Hazard Ratio (HR) e gli intervalli di confidenza al 95% (CIs). La OS considerando tutte le sedi tumorali è stata del 60%, mentre considerando le singole sedi tumorali è risultata del 49.0% per il cavo orale, 54.8% per l’orofaringe, 50.0% per l’ipofaringe e 63.4% per la laringe. Un’età avanzata alla diagnosi (HR = 1.04; 95% CI: 1.02-1.05) ed un avanzato stadio del tumore (HR = 2.00; 95% CI: 1.41-2.84) sono risultati fattori significativamente associati con la OS. Il rischio di ricorrenza è risultato associato con il consumo di alcolici (HR = 1.73; 95% CI: 1.00-2.97). Il rischio di sviluppare un secondo tumore primitivo è risutlato associato con uno stadio avanzato del tumore primario (HR = 2.75; 95% CI: 1.39-5.44) e con l’aver fumato per più di 40 anni (HR = 3.68; 95% CI: 1.10-12.30). In conclusione abbiamo notato che la OS differisce tra le sedi tumorali del tumore testa-collo. Lo stadio tumorale è risultato essere associato sia con la OS che con il rischo di sviluppare un secondo tumore primitivo. Il consumo di alcol e di tabacco sono risultati essere fattori prognostici, rispettivamente, per la ricorrenza e per l’insorgenza di un secondo tumore primitivo.

Distance Traveled to Head and Neck Cancer Provider: A Measure of Socioeconomic Status and Access

2019 ◽  
Vol 162 (2) ◽  
pp. 193-203 ◽  
Author(s):  
Sean T. Massa ◽  
Adam P. Liebendorfer ◽  
Jose P. Zevallos ◽  
Angela L. Mazul
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Survival ◽  
National Registry ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
Survival Models ◽  
Patient Factors

Objective Improved head and neck cancer survival has been associated with traveling farther distances for treatment, potentially due to patients seeking higher-quality facilities. This study investigates the role of both facility and confounding patient factors on this relationship. Study Design Review of national registry data. Setting National Cancer Database. Subjects and Methods Adults with head and neck cancer diagnosed from 2004 to 2014 were identified. Overall survival was compared among distance-to-facility quartiles via univariate and multivariate survival models. Then, the analysis was stratified by facility and patient factors, and the association between distance and survival was compared among strata. Results Overall survival was worst in the shortest-distance quartile (<5 miles; median survival, 80.7 months; 95% CI, 79.2-82.3), while other distance groups showed similar survival (range, 96.4-104 months). This finding remained in the multivariate model (adjusted hazard ratio vs first distance quartile: 0.88; 95% CI, 0.87-0.89). The association between survival and distance persisted in all subgroups when stratified by facility volume and type (adjusted hazard ratio range, 0.82-0.91), suggesting that facility quality does not fully account for this association. When stratified by income, distance remained statistically associated with survival but with a smaller effect size than that of income. Conclusion The association between distance to treating facility and head and neck cancer survival is limited to patients with worse survival outcomes living within 5 miles of the facility and is not fully explained by measures of facility quality.

Utilization and Survival of Postoperative Radiation or Chemoradiation for pT1-2N1M0 Head and Neck Cancer

2017 ◽  
Vol 158 (4) ◽  
pp. 677-684 ◽  
Author(s):  
Anna Lee ◽  
Babak Givi ◽  
Dylan F. Roden ◽  
Moses M. Tam ◽  
S. Peter Wu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Logistic Regression ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Odds Ratio ◽  
Cox Regression ◽  
Hazard Ratio ◽  
Postoperative Treatment ◽  
Extracapsular Extension

Objective To analyze the patterns of care and survival for pT1-2N1M0 head and neck cancer based on receipt of surgery alone, surgery + postoperative radiotherapy (S + RT), or surgery + postoperative chemoradiotherapy (S + CRT). Study Design Retrospective analysis. Setting National Cancer Database. Subjects and Methods We queried the database for patients with stage pT1-2N1M0 squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx between 2004 and 2012 who were treated with surgery with negative margins and no extracapsular extension. Logistic regression was used to assess predictors of receipt of postoperative treatment. Overall survival was assessed by the Kaplan-Meier method, and Cox regression analysis identified covariates that affected it. Results There were 1598 patients included in this study: 566 (35.4%) received surgery alone; 726 (45.4%), S + RT; and 306 (19.1%), S + CRT. The 5-year overall survival was 68.8%, 74.0%, and 87.8%, respectively ( P = .009 comparing S + RT and surgery alone, P < .001 for all other comparisons). On multivariable logistic regression, academic centers were associated with a decreased likelihood of S + RT (odds ratio = 0.71) and S + CRT (odds ratio = 0.66). Multivariable Cox regression demonstrated no difference in survival for S + RT over surgery alone (hazard ratio = 0.88, 95% CI = 0.70-1.09, P = .24); however, there was a survival benefit associated with S + CRT (hazard ratio = 0.57, 95% CI = 0.39-0.81, P = .002). Conclusion Nearly 65% of patients with pT1-2N1 head and neck cancer with negative margins and no extracapsular extension received S + RT or S + CRT. Improvement in survival was noted only for patients who received S + CRT.

scholarly journals The Clinical Characteristics and Prognostic Nomogram for Head and Neck Cancer Patients with Bone Metastasis

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Changxing Chi ◽  
Zhiyi Fan ◽  
Binbin Yang ◽  
He Sun ◽  
Zengpai Zheng
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Bone Metastasis ◽  
Head And Neck ◽  
Neck Cancer ◽  
Curve Analysis ◽  
Decision Curve Analysis ◽  
Cox Regression Analysis ◽  
Calibration Curves

Background. Head and neck cancer (HNC) is the sixth most common malignancy globally, and many demographics and clinicopathological factors influence its prognosis. This study aimed to construct and validate a prognostic nomogram to predict the prognosis of HNC patients with bone metastasis (BM). Methods. A total of 326 patients with BM from HNC were collected from the SEER database as the subjects of this study. In a ratio of 7 to 3, patients were randomly divided into training and validation groups. Independent prognostic factors for HNC patients with BM were identified by univariate and multivariate Cox regression analysis. The nomogram for predicting the prognosis was constructed, and the model was evaluated by receiver operating characteristic curves, calibration curves, and decision curve analysis. Result. The independent prognostic factors for HNC patients with BM included age, primary site, lung metastasis, and chemotherapy. The area under the curve predicting overall survival at 12, 24, and 36 months was 0.768, 0.747, and 0.723 in the training group and 0.729, 0.723, and 0.669 in the validation group, respectively. The calibration curves showed good agreement between the predicted and actual values for overall survival. In addition, the decision curve analysis showed that this prognostic nomogram model has a high clinical application. Conclusion. This study developed and validated a nomogram to predict overall survival in HNC patients with BM. The prognostic nomogram has high accuracy and utility to inform survival estimation and individualized treatment decisions.

A safety profile of sequential therapy for unresectable head and neck cancer: A retrospective analysis in a single institution

Toukeibu Gan ◽  
2012 ◽  
Vol 38 (3) ◽  
pp. 374-379
Author(s):  
Takanobu Shimada ◽  
Naomi Kiyota ◽  
Hideki Nishimura ◽  
Naoki Otsuki ◽  
Ryohei Sasaki ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Retrospective Analysis ◽  
Neck Cancer ◽  
Safety Profile ◽  
Sequential Therapy ◽  
Single Institution
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