The relationship between vitamin B12 and vitamin D levels and subjective cognitive complaints in patients with first episode major depressive disorder

IntroductionVitamin D has been shown to be crucial in the regulation of dopamine and its relationship to major depressive disorder.A five-year pre-interventional study of 25 hydroxy vitamin D levels in patients with major depressive disorder found values ranging from 17 to 32 ng/mL.COMT Val/Val genotype has been associated with a 20–40% more rapid breakdown of dopamine in the prefrontal cortex as compared to individuals with a Val/Met genotype.MethodsThis retrospective study gathered data concerning outcome measurements in patients who displayed a baseline 25-OH level < 30 mg/mL and initially treated with sublingual tablet form of 10,000 IU vitamin D3. These data were compared to post interventional depression outcome scores for patients switched to oral vitamin D3 drops at a dose of 10,000 IUs.ResultsScores on the MADRS 1–3 weeks following the vitamin D3 switch showed an improvement in mood with the lowering of scores on the MADRS.ConclusionsPatients with a COMT genotype of Val/Val showed clinical improvement with a switch from oral D3 sublingual tablets to oral D3 drops. Further studies are needed to draw from conclusions. Pre- and post-25-OH vitamin D levels and other dopamine synthesis variables including serum ferritin would be useful as well as prospective double-blind placebo controlled trials. The future use of genotype-specific and supportive approaches deserves serious investigation.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

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The relationship between plasma cytokine levels and antidepressant response in patients with first-episode major depressive disorder

Journal of Affective Disorders ◽

10.1016/j.jad.2021.03.036 ◽

2021 ◽

Author(s):

Xiaofeng Lan ◽

Yanling Zhou ◽

Fengchun Wu ◽

Kai Wu ◽

Yanni Zhan ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

First Episode ◽

Antidepressant Response ◽

Major Depressive ◽

Plasma Cytokine ◽

Cytokine Levels ◽

The Relationship

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The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine

The International Journal of Neuropsychopharmacology ◽

10.1017/s1461145705005195 ◽

2005 ◽

Vol 8 (04) ◽

pp. 523 ◽

Cited By ~ 60

Author(s):

George I. Papakostas ◽

Timothy Petersen ◽

Barry D. Lebowitz ◽

David Mischoulon ◽

Julie L. Ryan ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Vitamin B12 ◽

Serum Folate ◽

Major Depressive ◽

The Relationship

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Psychotic Features Abated with Vitamin D Treatment in a Patient with Major Depressive Disorder

Case Reports in Psychiatry ◽

10.1155/2020/2046403 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

David C. Fipps ◽

Elisabet Rainey

Keyword(s):

Vitamin D ◽

Major Depressive Disorder ◽

Case Report ◽

Depressive Disorder ◽

Serum Levels ◽

Psychotic Symptoms ◽

Major Depressive ◽

Vitamin D Levels ◽

Psychotic Features ◽

Low Serum

Introduction. Vitamin D deficiency is common in psychiatric populations, and vitamin D has been used as an add-on medication in major depressive disorder. Case Report. Here, we present the case of a 49-year-old man diagnosed with major depressive disorder, severe, with psychotic features, who was treated with antidepressants and underwent multiple antipsychotic trials. The patient was found to have low serum levels of vitamin D. During treatment with vitamin D, serum levels normalized and the patient’s psychotic symptoms abated. Conclusion. Ensuring adequate vitamin D levels could be a method of focus for the augmentation or treatment of psychotic features in major depressive disorder.

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