scholarly journals Intracellular mechanisms modulating gamma band activity in the pedunculopontine nucleus (PPN)

2016 ◽  
Vol 4 (12) ◽  
pp. e12787 ◽  
Author(s):  
Brennon R. Luster ◽  
Francisco J. Urbano ◽  
Edgar Garcia-Rill
Keyword(s):  
Pedunculopontine Nucleus ◽  
Gamma Band ◽  
Gamma Band Activity ◽  
Band Activity ◽  
Intracellular Mechanisms

scholarly journals High-threshold Ca2+channels behind gamma band activity in the pedunculopontine nucleus (PPN)

2015 ◽  
Vol 3 (6) ◽  
pp. e12431 ◽  
Author(s):  
Brennon Luster ◽  
Stasia D'Onofrio ◽  
Francisco Urbano ◽  
Edgar Garcia-Rill
Keyword(s):  
Pedunculopontine Nucleus ◽  
Gamma Band ◽  
High Threshold ◽  
Gamma Band Activity ◽  
Ca2 Channels ◽  
Band Activity

scholarly journals Gamma band activity in the RAS-intracellular mechanisms

2013 ◽  
Vol 232 (5) ◽  
pp. 1509-1522 ◽  
Author(s):  
E. Garcia-Rill ◽  
N. Kezunovic ◽  
S. D’Onofrio ◽  
B. Luster ◽  
J. Hyde ◽  
...  
Keyword(s):  
Gamma Band ◽  
Gamma Band Activity ◽  
Band Activity ◽  
Intracellular Mechanisms

scholarly journals Implications of gamma band activity in the pedunculopontine nucleus

2015 ◽  
Vol 123 (7) ◽  
pp. 655-665 ◽  
Author(s):  
E. Garcia-Rill ◽  
B. Luster ◽  
S. D’Onofrio ◽  
S. Mahaffey ◽  
V. Bisagno ◽  
...  
Keyword(s):  
Pedunculopontine Nucleus ◽  
Gamma Band ◽  
Gamma Band Activity ◽  
Band Activity

scholarly journals Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep

2014 ◽  
Vol 5 ◽  
Author(s):  
Francisco J. Urbano ◽  
Stasia M. D’Onofrio ◽  
Brennon R. Luster ◽  
Paige B. Beck ◽  
James Robert Hyde ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Pedunculopontine Nucleus ◽  
Gamma Band ◽  
Gamma Band Activity ◽  
Band Activity

scholarly journals Erratum to: Gamma band activity in the RAS-intracellular mechanisms

2014 ◽  
Vol 232 (5) ◽  
pp. 1523-1523
Author(s):  
E. Garcia-Rill ◽  
N. Kezunovic ◽  
S. D’Onofrio ◽  
B. Luster ◽  
J. Hyde ◽  
...  
Keyword(s):  
Gamma Band ◽  
Gamma Band Activity ◽  
Band Activity ◽  
Intracellular Mechanisms

scholarly journals Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

2015 ◽  
Vol 113 (3) ◽  
pp. 709-719 ◽  
Author(s):  
Stasia D'Onofrio ◽  
Nebojsa Kezunovic ◽  
James R. Hyde ◽  
Brennon Luster ◽  
Erick Messias ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Calcium Channels ◽  
Pedunculopontine Nucleus ◽  
Gamma Band ◽  
Calcium Sensor ◽  
Sensor Protein ◽  
Neuronal Calcium Sensor Protein ◽  
Gamma Band Activity ◽  
Gamma Band Oscillations ◽  
Band Activity

Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1. We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gamma-band activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1. Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.

scholarly journals Gamma Band Unit Activity and Population Responses in the Pedunculopontine Nucleus

2010 ◽  
Vol 104 (1) ◽  
pp. 463-474 ◽  
Author(s):  
Christen Simon ◽  
Nebojsa Kezunovic ◽  
Meijun Ye ◽  
James Hyde ◽  
A. Hayar ◽  
...  
Keyword(s):  
Paradoxical Sleep ◽  
Pedunculopontine Nucleus ◽  
Cholinergic Receptor ◽  
Gamma Band ◽  
Membrane Properties ◽  
Type I ◽  
Band Frequency ◽  
Population Responses ◽  
Gamma Band Activity ◽  
Band Activity

The pedunculopontine nucleus (PPN) is involved in the activated states of waking and paradoxical sleep, forming part of the reticular activating system (RAS). The studies described tested the hypothesis that single unit and/or population responses of PPN neurons are capable of generating gamma band frequency activity. Whole cell patch clamp recordings (immersion chamber) and population responses (interface chamber) were conducted on 9- to 20-day-old rat brain stem slices. Regardless of cell type (I, II, or III) or type of response to the nonselective cholinergic receptor agonist carbachol (excitation, inhibition, biphasic), almost all PPN neurons fired at gamma band frequency, but no higher, when subjected to depolarizing steps (50 ± 2 Hz, mean ± SE). Nonaccommodating neurons fired at 18–100 Hz throughout depolarizing steps, while most accommodating neurons exhibited gamma band frequency of action potentials followed by gamma band membrane oscillations. These oscillations were blocked by the sodium channel blocker tetrodotoxin (TTX), suggesting that at least some are mediated by sodium currents. Population responses in the PPN showed that carbachol induced peaks of activation in the theta and gamma range, while glutamatergic receptor agonists induced overall increases in activity at theta and gamma frequencies, although in differing patterns. Gamma band activity appears to be a part of the intrinsic membrane properties of PPN neurons, and the population as a whole generates different patterns of gamma band activity under the influence of specific transmitters. Given sufficient excitation, the PPN may impart gamma band activation on its targets.

scholarly journals Mechanism behind gamma band activity in the pedunculopontine nucleus

2011 ◽  
Vol 34 (3) ◽  
pp. 404-415 ◽  
Author(s):  
Nebojsa Kezunovic ◽  
Francisco J. Urbano ◽  
Christen Simon ◽  
James Hyde ◽  
Kristen Smith ◽  
...  
Keyword(s):  
Pedunculopontine Nucleus ◽  
Gamma Band ◽  
Gamma Band Activity ◽  
Band Activity

Gamma band activity in an auditory oddball paradigm studied with the wavelet transform

2001 ◽  
Vol 112 (7) ◽  
pp. 1219-1228 ◽  
Author(s):  
I.G Gurtubay ◽  
M Alegre ◽  
A Labarga ◽  
A Malanda ◽  
J Iriarte ◽  
...  
Keyword(s):  
Wavelet Transform ◽  
Gamma Band ◽  
Oddball Paradigm ◽  
Auditory Oddball ◽  
Gamma Band Activity ◽  
Auditory Oddball Paradigm ◽  
Band Activity

scholarly journals Increased Thalamic Gamma Band Activity Correlates with Symptom Relief following Deep Brain Stimulation in Humans with Tourette’s Syndrome

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44215 ◽  
Author(s):  
Nicholas Maling ◽  
Rowshanak Hashemiyoon ◽  
Kelly D. Foote ◽  
Michael S. Okun ◽  
Justin C. Sanchez
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Symptom Relief ◽  
Gamma Band ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Gamma Band Activity ◽  
Band Activity ◽  
Deep Brain
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