scholarly journals Osmotic diuresis by SGLT2 inhibition stimulates vasopressin‐induced water reabsorption to maintain body fluid volume

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Takahiro Masuda ◽  
Shigeaki Muto ◽  
Keiko Fukuda ◽  
Minami Watanabe ◽  
Ken Ohara ◽  
...  
Keyword(s):  
Body Fluid ◽  
Fluid Volume ◽  
Water Reabsorption ◽  
Osmotic Diuresis ◽  
Body Fluid Volume ◽  
Sglt2 Inhibition

scholarly journals Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat

2018 ◽  
Vol 315 (3) ◽  
pp. F653-F664 ◽  
Author(s):  
Takahiro Masuda ◽  
Yuko Watanabe ◽  
Keiko Fukuda ◽  
Minami Watanabe ◽  
Akira Onishi ◽  
...  
Keyword(s):  
Fluid Balance ◽  
Body Fluid ◽  
Fluid Intake ◽  
Sglt2 Inhibitor ◽  
Fluid Volume ◽  
Sprague Dawley ◽  
Body Fluid Volume ◽  
Sglt2 Inhibition ◽  
The Impact ◽  
Food And Fluid Intake

The chronic intrinsic diuretic and natriuretic tone of sodium-glucose cotransporter 2 (SGLT2) inhibitors is incompletely understood because their effect on body fluid volume (BFV) has not been fully evaluated and because they often increase food and fluid intake at the same time. Here we first compared the effect of the SGLT2 inhibitor ipragliflozin (Ipra, 0.01% in diet for 8 wk) and vehicle (Veh) in Spontaneously Diabetic Torii rat, a nonobese type 2 diabetic model, and nondiabetic Sprague-Dawley rats. In nondiabetic rats, Ipra increased urinary excretion of Na+ (UNaV) and fluid (UV) associated with increased food and fluid intake. Diabetes increased these four parameters, but Ipra had no further effect, probably because of its antihyperglycemic effect, such that glucosuria and, as a consequence, food and fluid intake were unchanged. Fluid balance and BFV, determined by bioimpedance spectroscopy, were similar among the four groups. To study the impact of food and fluid intake, nondiabetic rats were treated for 7 days with Veh, Ipra, or Ipra+pair feeding+pair drinking (Pair-Ipra). Pair-Ipra maintained a small increase in UV and UNaV versus Veh despite similar food and fluid intake. Pair-Ipra induced a negative fluid balance and decreased BFV, whereas Ipra or Veh had no significant effect compared with basal values. In conclusion, SGLT2 inhibition induces a sustained diuretic and natriuretic tone. Homeostatic mechanisms are activated to stabilize BFV, including compensatory increases in fluid and food intake.

scholarly journals A Possible Physiological Role of Atrial Natriuretic Peptide in Body Fluid Volume Regulation

1988 ◽  
Vol 13 ◽  
pp. S62-S68
Author(s):  
Yasunobu Hirata ◽  
Masao Ishii ◽  
Kazushige Fukui ◽  
Hiroshi Hayakawa ◽  
Shin-ichiro Namba ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Volume Regulation ◽  
Body Fluid ◽  
Physiological Role ◽  
Fluid Volume ◽  
Body Fluid Volume ◽  
Fluid Volume Regulation ◽  
Atrial Natriuretic

scholarly journals Apparent paradox of neurohumoral axis inhibition after body fluid volume depletion in patients with chronic congestive heart failure and water retention.

Heart ◽  
1994 ◽  
Vol 72 (6) ◽  
pp. 534-539 ◽  
Author(s):  
M D Guazzi ◽  
P Agostoni ◽  
B Perego ◽  
G Lauri ◽  
A Salvioni ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Body Fluid ◽  
Water Retention ◽  
Fluid Volume ◽  
Chronic Congestive Heart Failure ◽  
Volume Depletion ◽  
Apparent Paradox ◽  
Body Fluid Volume

scholarly journals Dehydration increases the density of C receptors for ANF on rat glomerular membranes

1990 ◽  
Vol 258 (4) ◽  
pp. R1084-R1088 ◽  
Author(s):  
M. C. Kollenda ◽  
A. M. Vollmar ◽  
G. A. McEnroe ◽  
A. L. Gerbes
Keyword(s):  
Binding Sites ◽  
Atrial Natriuretic Factor ◽  
Body Fluid ◽  
Fluid Volume ◽  
Control Group ◽  
Receptor Density ◽  
Lower Plasma ◽  
Short Term ◽  
Salt Loading ◽  
Body Fluid Volume

The present study determined the presence of two types of binding sites for atrial natriuretic factor (ANF), the B and C receptor, on rat glomerular membranes. The effect of short-term salt loading and dehydration on these two receptor populations was investigated consecutively. Salt-loaded rats did not show significant changes in plasma ANF concentrations or in the number of ANF binding sites. Water-deprived rats presented significantly lower plasma ANF concentrations (22.0 +/- 1.9 vs. 34.4 +/- 3.8 fmol/ml, P less than 0.01) and an increase in total receptor density (1,860 +/- 398 vs. 987 +/- 143 fmol/mg protein) as compared with the control group. Differentiation of both receptor populations showed that it was the C receptors that accounted for this increase (1,772 +/- 369 vs. 901 +/- 151 fmol/mg protein, P less than 0.05), whereas B-receptor density was unchanged (89 +/- 31 vs. 87 +/- 44 fmol/mg protein). These data suggest that C receptors for ANF are affected by changes of body fluid volume.

scholarly journals On the question of body fluid volume or sodium status influencing renin release.

1977 ◽  
Vol 267 (2) ◽  
pp. 321-338 ◽  
Author(s):  
J R Blair-West ◽  
A H Brook ◽  
P A Simpson
Keyword(s):  
Body Fluid ◽  
Fluid Volume ◽  
Renin Release ◽  
Body Fluid Volume

Role of Leptin in the Regulation of Body Fluid Volume and Pressures

2003 ◽  
Vol 10 (3) ◽  
pp. 211-218 ◽  
Author(s):  
Prabal K. Guha ◽  
Daniel Villarreal ◽  
Garry P. Reams ◽  
Ronald H. Freeman
Keyword(s):  
Body Fluid ◽  
Fluid Volume ◽  
Body Fluid Volume

Angiotensin II and III upregulate body fluid volume of the clam worm Perinereis sp. via angiotensin II receptors in different manners

Peptides ◽  
2005 ◽  
Vol 26 (12) ◽  
pp. 2452-2457 ◽  
Author(s):  
Ryousuke Satou ◽  
Tsutomu Nakagawa ◽  
Hiroki Ido ◽  
Masayuki Tomomatsu ◽  
Fumiaki Suzuki ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Body Fluid ◽  
Fluid Volume ◽  
Angiotensin Ii Receptors ◽  
Body Fluid Volume

scholarly journals 948-52 Paradoxical Neurohumoral Axis Inhibition After Body Fluid Volume Depletion in Patients with Congestive Heart Failure and Water Retention

1995 ◽  
Vol 25 (2) ◽  
pp. 178A ◽  
Author(s):  
Maurizio D. Guazzi ◽  
Piergiuseppe Agostoni ◽  
G. Battista Perego ◽  
Gianfranco Lauri ◽  
Francesco Giraldi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Body Fluid ◽  
Water Retention ◽  
Fluid Volume ◽  
Volume Depletion ◽  
Body Fluid Volume

Control of body fluid volume regarded as a feedback system

1966 ◽  
Vol 4 (6) ◽  
pp. 567-574 ◽  
Author(s):  
M. Nagasaka ◽  
K. Shimizu ◽  
T. Maeda ◽  
Y. Yoshitoshi ◽  
S. Koshikawa ◽  
...  
Keyword(s):  
Body Fluid ◽  
Feedback System ◽  
Fluid Volume ◽  
Body Fluid Volume

The role of body fluid volume and osmolality in thermoregulation and cardiovascular adjustment

1994 ◽  
Vol 1 ◽  
pp. 28
Author(s):  
H. Nose ◽  
M. Chen ◽  
A. Takamata ◽  
T. Morimoto
Keyword(s):  
Body Fluid ◽  
Fluid Volume ◽  
Body Fluid Volume ◽  
Cardiovascular Adjustment
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