scholarly journals C-reactive Protein Detection in Gingival Crevicular Fluid as an Acute Systemic Inflammation Biomarker in Patients with Severe Periodontitis

2013 ◽  
Keyword(s):  
Systemic Inflammation ◽  
Gingival Crevicular Fluid ◽  
Protein Detection ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Severe Periodontitis ◽  
Crevicular Fluid

C-reactive protein in gingival crevicular fluid may be indicative of systemic inflammation

2010 ◽  
Vol 37 (9) ◽  
pp. 797-804 ◽  
Author(s):  
Emma Megson ◽  
Tracy Fitzsimmons ◽  
Kencana Dharmapatni ◽  
P. Mark Bartold
Keyword(s):  
Systemic Inflammation ◽  
Gingival Crevicular Fluid ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Crevicular Fluid

scholarly journals A COMPARATIVE EVALUATION OF C-REACTIVE PROTEIN GCF LEVEL IN PERIODONTITIS PATIENTS AFTER SCALING AND ROOT PLANING WITH AND WITHOUT DIODE LASER

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Sangeeta Roy ◽  
C.S. Joshi ◽  
Pradeep Shukla ◽  
Gaurav Malhotra ◽  
Prerna Kataria ◽  
...  
Keyword(s):  
Diode Laser ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Type I ◽  
Scaling And Root Planing ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Root Planing ◽  
Crevicular Fluid

Background and Objectives: C?reactive protein (CRP) is a type I acute phase reactant. A number of studies have reported elevated gingival crevicular fluid (GCF) CRP levels in periodontitis subjects, which decrease following periodontal therapy. Effect of diode laser as an adjuct to Scaling & Root planing is also well stablished. The aim of the present study was to evaluate the effect of periodontal treatment SRP with diode laser, on CRP levels in GCF in patients with chronic periodontitis. Materials and Methods: A total of 40 subjects with moderate periodontitis based on community periodontal index scores, were included in the study. Periodontal therapy was performed dividing each side of jaw as a group (Split mouth); one side SRP alone & another Diode laser with SRP. GCF was collected from each subject at Baseline (prior to treatment) and 1 month after periodontal therapy. The collected sample was subjected to biochemical analysis to detect CRP levels by using a commercially available highly sensitive kit. Results: The present study demonstrated that the mean CRP values at baseline were found to be 0.11043mg/l in side-I (side treated with SRP alone); 0.11042mg/l in side-II (side treated with SRP & laser) of the patient, which reduced to 0.4148 mg/L in side I and 0.3985mg/L in side II after treatment, which are highly significant according to statistical analysis but the changes between two sides were non- significant statistically. Interpretation and Conclusion: Within the limitations of this study, it can be concluded that periodontal therapy is able to reduce the GCF C reactive protein level significantly, but there was no statistically significant result in CRP level, between sides treated with SRP & SRP with laser. Key words: Chronic periodontitis, C?reactive protein, gingival crevicular fluid, Scaling and root planing, Diode laser

Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers

2004 ◽  
Vol 83 (2) ◽  
pp. 156-160 ◽  
Author(s):  
F. D’Aiuto ◽  
M. Parkar ◽  
G. Andreou ◽  
J. Suvan ◽  
P.M. Brett ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Inflammatory Markers ◽  
Healthy Subjects ◽  
Periodontal Therapy ◽  
Serological Markers ◽  
Intervention Trial ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Severe Periodontitis ◽  
Inflammatory Burden

Severe periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. However, the nature of this association has not been determined. Our aim was to assess whether the degree of response to periodontal therapy was associated with changes in serological markers of systemic inflammation. Ninety-four systemically healthy subjects with severe generalized periodontitis participated in a prospective six-month blind intervention trial. Periodontal parameters and inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were evaluated prior to and 2 and 6 mos after delivery of standard non-surgical periodontal therapy. Six months after treatment, significant reductions in serum IL-6 (p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1–0.4 ng/L) and CRP (p < 0.0001, median decrease 0.5 mg/L, 95% CI 0.4–0.7) were observed. Decreases in inflammatory markers were significant in subjects with above average clinical response to periodontal therapy after correction for possible confounders. Periodontitis may add to the systemic inflammatory burden of affected individuals.

scholarly journals Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1238
Author(s):  
Claudia Da Venezia ◽  
Nayib Hussein ◽  
Marcela Hernández ◽  
Johanna Contreras ◽  
Alicia Morales ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Low Grade ◽  
Adult Women ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Luminex Technology ◽  
Hs Crp ◽  
Crevicular Fluid

Cardiovascular diseases (CVD) are highly prevalent non-communicable diseases worldwide. Periodontitis may act as a non-traditional cardiovascular risk (CVR) factor, linked by a low-grade systemic inflammation mediated by C-reactive protein (CRP). Patients with periodontitis reported higher serum CRP levels; however, a CRP systemic and periodontal correlation in gingival crevicular fluid (GCF) and its CVR impact have been barely studied. We aimed to assess the association between periodontal diseases and CVR in a group of adult women, based on serum high-sensitivity CRP (hs-CRP) levels; and secondly, to determine the association between serum and GCF CRP levels. Gingival crevicular fluid and blood samples were obtained from women with periodontitis, gingivitis, and healthy controls. Serum and GCF CRP were determined by turbidimetric method and Luminex technology, respectively. Data were analyzed and adjusted by CVR factors. All women presented moderate CVR, without an evident association between serum hs-CRP levels and periodontal diseases. While serum hs-CRP concentrations did not significantly differ between groups, patients with gingivitis and periodontitis showed higher CRP levels in GCF, which positively correlated to CRP detection in serum.

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