Relationship of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene polymorphisms with metabolic syndrome and type 2 diabetes

Abstract Background The chronic complications of Type 2 Diabetes (T2D) such as macrovascular disease is amplified with the increase in the number of metabolic syndrome (MetS) risk factors. This research aims to study the relationship of MetS, diagnosed by the International Diabetes Federation (IDF) or revised National Cholesterol Education Programs Adult Treatment Panel III (NCEP ATP III) criteria, with glycemic control, Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), C-peptide, and insulin resistance in T2D patients.Methods The study is a cross-sectional observational study which, involved 485 T2D patients who are receiving treatment at the University Kebangsaan Malaysia Medical Center (UKMMC), Kuala Lumpur, Malaysia. The MetS among the T2D patients was diagnosed based on IDF and revised NCEP ATP III criteria. C-peptide and HbA1c levels were determined by an automated quantitative immunoassay analyzer and high-performance liquid chromatography, respectively. The MetS factors; FBG, triglyceride, and high-density lipoprotein cholesterol were measured by spectrophotometer. Results Application of the IDF and revised NCEP ATP III criteria respectively resulted in 73% and 85% of the T2D subjects being diagnosed with MetS. The concordance of these criteria in diagnosing MetS among T2D patients was low (κ =0.33, P<0.001). Both IDF and revised NCEP ATP III criteria indicated that T2D patients with 5 MetS factors had higher insulin resistance (P=2.1×10-13;1.4×10-11), C-peptide (P=1.21×10-13; 4.1×10-11), FBG (P=0.01; 0.021), and HbA1c (P=0.039; 0.018) than those T2D patients without MetS, respectively. Conclusion Although there is a low concordance between IDF and revised NCEP ATP III criteria in the diagnosis of MetS among T2D patients, both criteria showed that T2D patients with 5 MetS factors had higher insulin resistance, C-peptide, FBG, and HbA1c.

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Vitamin D Receptor Gene Polymorphisms, Metabolic Syndrome, and Type 2 Diabetes in Iranian Subjects: No Association with Observed SNPs

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000270 ◽

2016 ◽

Vol 86 (1-2) ◽

pp. 71-80 ◽

Cited By ~ 1

Author(s):

Sakineh Shab-Bidar ◽

Tirang R. Neyestani ◽

Abolghassem Djazayery

Keyword(s):

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Single Nucleotide ◽

Receptor Gene Polymorphisms

Abstract.Objective: This study aimed to investigate the associations between metabolic syndrome and type 2 diabetes and the presence of single nucleotide polymorphism of the vitamin D receptor gene in Iranian subjects with type 2 diabetes. Subjects and methods: Overall, 730 Iranian subjects (372 patients and 358 controls) were enrolled in this case-control study. Single nucleotide polymorphisms of the vitamin D receptor gene (FokI, BsmI, ApaI, and TaqI) were genotyped using the restriction fragment length polymorphism method. The statistical difference in genotype distribution among the groups was assessed by χ2 test. Logistic regression was performed to calculate odds ratios for the association of the genotype frequencies in different groups with the risk of metabolic syndrome and type 2 diabetes. Results: The most common genotypes for BsmI, ApaI, TaqI, and FokI were Bb, Aa, TT, and FF, respectively. Adjusted χ2 test revealed that there was no difference between the groups in the genotypes frequencies of 4 vitamin D receptor polymorphisms in type 2 diabetes subjects. On the other hand, type 2 diabetes subjects with Tt genotype presented a signifi cantly higher fasting blood glucose than those with TT and tt genotypes in TaqI polymorphisms (p = 0.009). Logistic regression showed no association between metabolic syndrome risk and vitamin D receptor genotypes. Conclusion: We found no evidence for the association between vitamin D receptor gene polymorphisms and the risk for type 2 diabetes and metabolic syndrome in Iranian subjects. Further examinations using genome-wide association in large prospective cohort studies are warranted.

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