11 Role of KLK4 in Dental Enamel Formation

2012 ◽  
Author(s):  
James P. Simmer ◽  
Yuanyuan Hu ◽  
Amelia S. Richardson ◽  
Jan C.C. Hu
Keyword(s):  
Dental Enamel ◽  
Enamel Formation

scholarly journals The genetics of amelogenesis imperfecta: a review of the literature

2005 ◽  
Vol 13 (3) ◽  
pp. 212-217 ◽  
Author(s):  
Maria Cristina Leme Godoy dos Santos ◽  
Sergio Roberto Peres Line
Keyword(s):  
Autosomal Recessive ◽  
Autosomal Dominant ◽  
Dental Enamel ◽  
Matrix Proteins ◽  
Specific Gene ◽  
Enamel Formation ◽  
Complex Process ◽  
Different Types ◽  
Kallikrein 4

A melogenesis imperfecta (AI) is a group of inherited defects of dental enamel formation that show both clinical and genetic heterogeneity. Enamel findings in AI are highly variable, ranging from deficient enamel formation to defects in the mineral and protein content. Enamel formation requires the expression of multiple genes that transcribes matrix proteins and proteinases needed to control the complex process of crystal growth and mineralization. The AI phenotypes depend on the specific gene involved, the location and type of mutation, and the corresponding putative change at the protein level. Different inheritance patterns such as X-linked, autosomal dominant and autosomal recessive types have been reported. Mutations in the amelogenin, enamelin, and kallikrein-4 genes have been demonstrated to result in different types of AI and a number of other genes critical to enamel formation have been identified and proposed as candidates for AI. The aim of this article was to present an evaluation of the literature regarding role of proteins and proteinases important to enamel formation and mutation associated with AI.

Role of amelogenin self-assembly in protein-mediated dental enamel formation

2010 ◽  
pp. 369-374
Author(s):  
Henry C. Margolis ◽  
Felicitas B. Wiedemann-Bidlack ◽  
Barbara Aichmayer ◽  
Peter Fratzl ◽  
Seo-Young Kwak ◽  
...  
Keyword(s):  
Self Assembly ◽  
Dental Enamel ◽  
Enamel Formation

scholarly journals Functions of KLK4 and MMP-20 in dental enamel formation

2008 ◽  
Vol 389 (6) ◽  
Author(s):  
Yuhe Lu ◽  
Petros Papagerakis ◽  
Yasuo Yamakoshi ◽  
Jan C.-C. Hu ◽  
John D. Bartlett ◽  
...  
Keyword(s):  
Autosomal Recessive ◽  
Dental Enamel ◽  
Organic Matrix ◽  
Maturation Stage ◽  
Protein Cleavage ◽  
Enamel Formation ◽  
Residual Protein ◽  
Kallikrein 4 ◽  
Enamel Protein ◽  
Enamel Proteins

Abstract Two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-20). The late protease is kallikrein 4 (KLK4). Mutations in MMP20 and KLK4 both cause autosomal recessive amelogenesis imperfecta, a condition featuring soft, porous enamel containing residual protein. MMP-20 is secreted along with enamel proteins by secretory-stage ameloblasts. Enamel protein-cleavage products accumulate in the space between the crystal ribbons, helping to support them. MMP-20 steadily cleaves accumulated enamel proteins, so their concentration decreases with depth. KLK4 is secreted by transition- and maturation-stage ameloblasts. KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion. The principle functions of MMP-20 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins.

scholarly journals Fluoride Induces Endoplasmic Reticulum Stress in Ameloblasts Responsible for Dental Enamel Formation

2005 ◽  
Vol 280 (24) ◽  
pp. 23194-23202 ◽  
Author(s):  
Kaori Kubota ◽  
Daniel H. Lee ◽  
Masahiro Tsuchiya ◽  
Conan S. Young ◽  
Eric T. Everett ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Dental Enamel ◽  
Enamel Formation

Function and repair of dental enamel – Potential role of epithelial transport processes of ameloblasts

Pancreatology ◽  
2015 ◽  
Vol 15 (4) ◽  
pp. S55-S60 ◽  
Author(s):  
Gábor Varga ◽  
Beáta Kerémi ◽  
Erzsébet Bori ◽  
Anna Földes
Keyword(s):  
Potential Role ◽  
Epithelial Transport ◽  
Dental Enamel ◽  
Transport Processes

scholarly journals A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation

2017 ◽  
Vol 10 (465) ◽  
pp. eaah4598 ◽  
Author(s):  
Claudio Cantù ◽  
Pierfrancesco Pagella ◽  
Tania D. Shajiei ◽  
Dario Zimmerli ◽  
Tomas Valenta ◽  
...  
Keyword(s):  
Tooth Enamel ◽  
Enamel Formation ◽  
Transcriptional Cofactors

scholarly journals Oral Signs and HLA-DQB1*02 Haplotypes in the Celiac Paediatric Patient: A Preliminary Study

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
M. Erriu ◽  
G. M. Abbate ◽  
F. M. G. Pili ◽  
F. Novara ◽  
G. Orrù ◽  
...  
Keyword(s):  
Haplotype Analysis ◽  
Pediatric Patients ◽  
Dental Enamel ◽  
Decisive Role ◽  
Recurrent Aphthous Stomatitis ◽  
Enamel Defects ◽  
Allele Expression ◽  
Preliminary Study ◽  
Oral Examinations

Celiac disease (CD) diagnosis can be extremely challenging in the case of atypical patterns. In this context, oral signs seem to play a decisive role in arousing suspicion of these forms of the disease. At the same time, the different expressions of the HLA-DQB1*02 allele apparently seem to facilitate the interpretation of signs and highlighted symptoms. The aim of this work was to verify whether it is possible to identify a correlation between the development of oral signs and different DQ2 haplotypes in celiac pediatric patients. 44 celiac patients with a medium age of 9.9 were studied. Oral examinations were performed in order to identify recurrent aphthous stomatitis (RAS) and dental enamel defects (DED). The diagnosis of DED resulted as being related to allele expression ( value = 0.042) while it was impossible to find a similar correlation with RAS. When both oral signs were considered, there was an increase in correlation with HLA-DQB1*02 expression ( value = 0.018). The obtained results identified both the fundamental role that dentists can play in early diagnosis of CD, as well as the possible role of HLA haplotype analysis in arousing suspicion of atypical forms of the disease.

Type 1 diabetes mellitus effects on dental enamel formation revealed by microscopy and microanalysis

2017 ◽  
Vol 47 (3) ◽  
pp. 306-313 ◽  
Author(s):  
Bruna Larissa Lago Silva ◽  
Danila Lima Medeiros ◽  
Ana Prates Soares ◽  
Sérgio Roberto Peres Line ◽  
Maria das Graças Farias Pinto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Dental Enamel ◽  
Enamel Formation
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