Interaction of Vitamin D Metabolites with Parathyroid Hormone and Vasopressin

1979 ◽  
pp. 315-324
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D Metabolites

Circulating levels of calciotropic hormones during treatment with nasal salmon calcitonin

1991 ◽  
Vol 125 (2) ◽  
pp. 127-131 ◽  
Author(s):  
Gorm Thamsborg ◽  
Tommy L. Storm ◽  
Henrik Daugaard ◽  
Søren Schifter ◽  
Ole H. Sørensen
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Nasal Spray ◽  
Salmon Calcitonin ◽  
Serum Levels ◽  
Treated Group ◽  
Human Calcitonin ◽  
Vitamin D Metabolites ◽  
Calciotropic Hormones ◽  
Circulating Levels

Abstract. Circulating levels of calciotropic hormones were measured during one year of treatment with either 200 IU of salmon calcitonin daily or placebo as a nasal spray in 20 postmenopausal women with a former Colles' fracture. A supplement of 0.5 gram elemental calcium was given to all participants. Serum levels of parathyroid hormone and human calcitonin were determined with radioimmunoassays, and serum levels of vitamin D metabolites were determined with protein binding assays. We did not find any significant differences between the two groups with respect to serum levels of calciotropic hormones. In the salmon calcitonin treated group there was a tendency towards a small decrease in serum levels of human calcitonin and an increase in serum levels of calcitriol. Our results suggest that treatment with 200 IU of salmon calcitonin daily as a nasal spray does not markedly affect fasting serum levels of parathyroid hormone, human calcitonin, and vitamin D metabolitis.

Effects of 1,25- and 24,25-dihydroxycholecalciferol on parathyroid hormone release from human parathyroid cells in vitro

1984 ◽  
Vol 105 (3) ◽  
pp. 354-359 ◽  
Author(s):  
Claes Rudberg ◽  
Göran Åkerström ◽  
Henry Johansson ◽  
Sverker Ljunghall ◽  
Jan Malmaeus ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Parathyroid Tissue ◽  
Vitamin D Metabolites ◽  
Hormone Release ◽  
High Doses ◽  
Parathyroid Hormone Release ◽  
Dispersed Cells

Abstract. The effects of 125-dihydroxycholecalciferol (1,25-(OH)2D3) and 24,25-dihydroxycholecalciferol (24,25-(OH)2D3) on parathyroid hormone (PTH) release from human parathyroid cells were investigated using an in vitro system of dispersed cells. The cells were obtained from 7 patients with primary hyperparathyroidism (HPT) and adenoma, 4 patients with primary HPT due to hyperplasia and 2 patients with parathyroid hyperplasia secondary to chronic renal failure. The dispersed cells were incubated in tissue culture medium at low, normal and high external calcium concentrations for 2–16 h. There was a gradual suppression of PTH release (5–55%) when the calcium concentration in the medium was increased from 0.5 to 3.0 mM, thus indicating retained regulation of hormone release. The addition of 1,25-(OH)2D3 in concentrations of 0.1 and 1 ng/ml and of 24,25-(OH)2D3 in concentrations of 1.0 and 10 ng/ml during the incubations did not further affect the amount of PTH released by the cells. The concentrations of the different vitamin D metabolites tested closely correspond to levels observed under normal physiological conditions and during treatment with high doses of vitamin D in vivo. Thus, the findings contradict the idea of any direct short-term regulatory effect of either 1,25-(OH)2D3 or 24,25-(OH)2D3 on the secretion of PTH from hyperfunctioning human parathyroid tissue.

scholarly journals Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat.

1986 ◽  
Vol 78 (5) ◽  
pp. 1296-1301 ◽  
Author(s):  
J Silver ◽  
T Naveh-Many ◽  
H Mayer ◽  
H J Schmelzer ◽  
M M Popovtzer
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Gene Transcription ◽  
Vitamin D Metabolites

Calcidiol, Calcitriol and Parathyroid Hormone Serum Concentrations in Institutionalized and Ambulatory Elderly in Switzerland

1999 ◽  
Vol 69 (2) ◽  
pp. 96-105 ◽  
Author(s):  
Theiler ◽  
Stähelin ◽  
Tyndall ◽  
Binder ◽  
Somorjai ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D Deficiency ◽  
Elderly People ◽  
Elderly Subjects ◽  
Bone Resorption Marker ◽  
Vitamin D Metabolites ◽  
Serum Concentrations ◽  
Institutionalized Elderly ◽  
Serum Ipth

Aim: The aim of the present study was to measure concentrations of vitamin D metabolites and intact parathyroid hormone (iPTH) serum concentrations and an urinary bone resorption marker in two groups of elderly subjects, who differed markedly in their sedentary status and seasonality. Design: 193 institutionalized elderly people of a long-stay geriatric ward (106 women: mean age 82; 87 men: mean age 78) were studied during wintertime. 312 ambulatory elderly people (109 women: mean age 74; 203 men: mean age 76) were studied during summertime. Concentrations of calcidiol (25(OH)D), calcitriol (1,25(OH)2D) and serum iPTH, as well as urinary N-telopeptides (NTX) were measured. Results: Vitamin D deficiency (defined as serum 25(OH)D < 12 ng/ml) was present in 86% of institutionalized at the expected nadir (wintertime), compared to 15% of the ambulatory elderly subjects at the expected maximum (summertime). Serum calcitriol concentrations were significantly lower in institutionalized subjects (p = .0001). However intact PTH concentrations did not differ significantly between institutionalized and ambulatory elderly. Institutionalized and female subjects showed higher urinary NTX excretion (female institutionalized: 131.9; female ambulatory: 66.8/male institutionalized: 76.3 male ambulatory: 45.8 nmol/mmol). Conclusion: This cross-sectional study documented very low serum calcidiol and calcitriol concentrations and high urinary N-telopeptide excretion in institutionalized elderly people. There was no difference in serum iPTH concentrations between institutionalized and ambulatory elderly. This finding could not be explained by the differences in calcidiol and calcitriol concentration, nor urinary NTX excretion. These results suggest that other factors than vitamin D deficiency, such as lower mobility status and sedentary life style, might have an important role in the regulation of iPTH and mechanisms of bone loss in the elderly.

Perinatal parathyroid hormone, vitamin D metabolites, and calcitonin in man

1980 ◽  
Vol 239 (5) ◽  
pp. E385-E390 ◽  
Author(s):  
P. Wieland ◽  
J. A. Fischer ◽  
U. Trechsel ◽  
H. R. Roth ◽  
K. Vetter ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Plasma Levels ◽  
Maternal Blood ◽  
Sign Test ◽  
Blood Levels ◽  
Vitamin D Metabolites ◽  
Dihydroxyvitamin D ◽  
Umbilical Blood ◽  
Arteriovenous Difference

Plasma levels of calcium and of parathyroid hormone (PTH) were comparable in the mothers at delivery and in nonpregnant controls; magnesium was decreased (P < 0.001) in maternal blood; and phosphate (P < 0.001), 1,25-dihydroxyvitamin D (1,25(OH)2D) (P < 0.001), and calcitonin (CT) (P < 0.01) were raised. Cord levels of calcium (P < 0.01), magnesium (P < 0.05), and CT (P < 0.01) were higher, and PTH (P < 0.01) was lower than in the maternal blood. Levels of 25(OH)D, 1,25(OH)2D, and 24,25(OH)2D lower in fetal than in maternal blood (P < 0.01) and significant linear correlations between the vitamin D metabolites examined in mothers and neonates (P < 0.001) are consistent with a diffusion barrier across the placenta and/or different affinities of binding proteins. Plasma levels of 25(OH)D and 24,25(OH)2D were significantly related (P < 0.01), suggesting precursor product type, relationships. Levels of 1,25(OH)2D higher in arterial than in venous umbilical blood (P = 0.06, sign test; P < 0.005, paired t test) suggest that the fetus participates in the synthesis of 1,25(OH)2D. Maternal PTH was significantly related to the arteriovenous difference of 1,25(OH)2D levels (P < 0.01) in cord blood, and it possibly enhances the synthesis of 1,25(OH)2D during the final stage of fetal development.

Vitamin D Metabolites and Parathyroid Hormone in Cushing’s Syndrome: Relationship to Calcium and Phosphorus Homeostasis*

1982 ◽  
Vol 54 (5) ◽  
pp. 1039-1044 ◽  
Author(s):  
JAMES W. FINDLING ◽  
NANCY D. ADAMS ◽  
JACOB LEMANN ◽  
RICHARD W. GRAY ◽  
CAROL J. THOMAS ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Vitamin D Metabolites ◽  
Calcium And Phosphorus
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