Dynamic cerebral perfusion parameters and magnetic nanoparticle accumulation assessed by AC biosusceptometry

2020 ◽  
Vol 65 (3) ◽  
pp. 343-351
Author(s):  
André Gonçalves Próspero ◽  
Guilherme Augusto Soares ◽  
Gustavo Morlin Moretto ◽  
Caio C. Quini ◽  
Andris Figueiroa Bakuzis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Magnetic Nanoparticle ◽  
Brain Perfusion ◽  
Circulation Time ◽  
New Approaches ◽  
Magnetic Particle Imaging ◽  
Approaches To Study ◽  
Magnetic Resonance Imaging Mri ◽  
Particle Imaging ◽  
The Brain

AbstractCerebral blood flow (CBF) assessment is mainly performed by scintigraphy, computed tomography (CT) and magnetic resonance imaging (MRI). New approaches to assess the CBF through the passage of magnetic nanoparticles (MNPs) to blood-brain barrier (BBB) are convenient to help decrease the use of ionizing radiation and unleash the required MRI schedule in clinics. The development of nanomedicine and new biomedical devices, such as the magnetic particle imaging (MPI), enabled new approaches to study dynamic brain blood flow. In this paper, we employed MNPs and the alternating current biosusceptometry (ACB) to study the brain perfusion. We utilized the mannitol, before the MNPs, injection to modulate the BBB permeability and study its effects on the circulation time of the MNPs in the brain of rats. Also, we characterized a new ACB sensor to increase the systems’ applicability to study the MNPs’ accumulation, especially in the animals’ brain. Our data showed that the injection of mannitol increased the circulation time of MNPs in the brain. Also, the mannitol increased the accumulation of MNPs in the brain. This paper suggests the use of the ACB as a tool to study brain perfusion and accumulation of MNPs in studies of new nano agents focused on the brain diagnostics and treatment.

Atlas of 99mTc-HMPAO SPECT brain perfusion in pediatric brain disorders

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Saleh A Othman ◽  
Keyword(s):  
Blood Flow ◽  
Neuronal Activity ◽  
Pediatric Patients ◽  
Brain Perfusion ◽  
Brain Disorders ◽  
Hmpao Spect ◽  
Perfusion Scan ◽  
Pediatric Brain ◽  
The Brain ◽  
99Mtc Hmpao

Background: Blood flow to the brain is in parallel with brain metabolism in almost all brain disorders except in brain tumors and therefore regional cerebral blood flow can be used as a marker of metabolic brain activity and hence it is closely linked to neuronal activity, the activity distribution is presumed to reflect neuronal activity levels in different areas of the brain. Purpose: The aim of this work is to demonstrate to pediatrician in general and pediatric neurologist in particular the variations in cerebral perfusion during normal development which should be taken into consideration at the time of interpreting SPECT brain perfusion scan in different pediatric brain disorders. Method: Brain SPECT was performed 10 minutes after an intravenous injection of 11.1 MBq/kg (0.3 mCi/kg), and the minimum dose is 185 MBq (5 mCi) of 99mTc-HMPAO (4). Results: This was a retrospective analysis of SPECT brain perfusion scan of pediatric patients performed between October 2015 and December 2019 at our institution. We selected normal and abnormal studies in pediatric population with age range (5 months - 14 years). Conclusion: Although anatomic cross sectional imaging give details of neurological structural changes, SPECT perfusion mirrors indirectly both metabolic and neuronal activity changes. Therefore, accurate interpretation of SPECT perfusion will consolidate its role as part of the diagnostic protocol and used when the findings of other imaging modalities do not explain the symptoms or fail partially or completely in determining the etiology of brain disorders in pediatric patients.

Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

2020 ◽  
Vol 56 (24) ◽  
pp. 3504-3507 ◽  
Author(s):  
Lucy Gloag ◽  
Milad Mehdipour ◽  
Marina Ulanova ◽  
Kevin Mariandry ◽  
Muhammad Azrhy Nichol ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticle ◽  
Magnetic Particle ◽  
Zero Valent Iron ◽  
Oxide Shell ◽  
Iron Core ◽  
Shell Nanoparticles ◽  
Magnetic Particle Imaging ◽  
Nanoparticle Imaging ◽  
Particle Imaging

Zero valent iron core–iron oxide shell nanoparticles coated with a multi-phosphonate brush co-polymer are shown to be small and effective magnetic nanoparticle imaging tracers.

scholarly journals Ferrohydrodynamic modeling of magnetic nanoparticle harmonic spectra for magnetic particle imaging

2015 ◽  
Vol 118 (17) ◽  
pp. 173906 ◽  
Author(s):  
Rohan Dhavalikar ◽  
Lorena Maldonado-Camargo ◽  
Nicolas Garraud ◽  
Carlos Rinaldi
Keyword(s):  
Magnetic Nanoparticle ◽  
Magnetic Particle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals Tracking Adoptive T Cell Therapy Using Magnetic Particle Imaging

2020 ◽  
Author(s):  
Angelie Rivera-Rodriguez ◽  
Lan B. Hoang-Minh ◽  
Andreina Chiu-Lam ◽  
Nicole Sarna ◽  
Leyda Marrero-Morales ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Solid Tumors ◽  
Magnetic Particle ◽  
Ex Vivo ◽  
Intraventricular Administration ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
The Brain

ABSTRACTAdoptive cellular therapy (ACT) is a potent strategy to boost the immune response against cancer. ACT is an effective treatment for blood cancers, such as leukemias and lymphomas, but faces challenges treating solid tumors and cancers in locations like the brain. A critical step for success of ACT immunotherapy is achieving efficient trafficking of T cells to solid tumors, and the non-invasive and quantitative tracking of adoptively transferred T cell biodistribution would accelerate its development. Here, we demonstrate the use of Magnetic Particle Imaging (MPI) to non-invasively track ACT T cells in vivo. Labeling T cells with the superparamagnetic iron oxide nanoparticle tracer ferucarbotran did not affect T cell viability, phenotype, or cytotoxic function in vitro. Following ACT, ferucarbotran-labeled T cells were detected and quantified using MPI ex vivo and in vivo, in a mouse model of invasive brain cancer. Proof-of-principle in vivo MPI demonstrated its capacity to detect labeled T cells in lungs and liver after intravenous administration and to monitor T cell localization in the brain after intraventricular administration. Ex vivo imaging using MPI and optical imaging suggests accumulation of systemically administered ferucarbotran-labeled T cells in the brain, where MPI signal from ferucarbotran tracers and fluorescently tagged T cells were observed. Ex vivo imaging also suggest differential accumulation of nanoparticles and viable T cells in other organs like the spleen and liver. These results support the use of MPI to track adoptively transferred T cells and accelerate the development of ACT treatments for brain tumors and other cancers.

scholarly journals Оптимизация уравнения для вычисления коэффициента заполнения при проектировании сборок Хальбаха

2021 ◽  
Vol 47 (4) ◽  
pp. 3
Author(s):  
F. Balci ◽  
A. Bingolbali ◽  
N. Dogan ◽  
M. Irfan
Keyword(s):  
Magnetic Flux ◽  
Flux Density ◽  
Fill Factor ◽  
Mathematical Expression ◽  
Magnetic Flux Density ◽  
Geometrical Parameters ◽  
Magnetic Particle Imaging ◽  
Proposed Model ◽  
Magnetic Resonance Imaging Mri ◽  
Particle Imaging

Selection (spatial in-homogenous) and excitation (spatially homogenous) fields are designed with Halbach magnets for magnetic particle imaging (MPI) and magnetic resonance imaging (MRI). Permanent magnet parameters (length and remanent flux density) and geometrical parameters (fill factor (FF), number of magnets, and system radius) are key factors for Halbach applications. The effect of fill factor ratio at magnetic flux density was investigated with 4 and 8 cylindrical magnets. A new mathematical expression was developed for accurate placement of the magnets even at 100% filling ratio (FF=1). Numerical simulations were conducted for the proposed model and magnetic flux density of 4 magnets system was 17% more accurate as compared to the model in the literature.

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