Pancreatic lipase assays: time for a change towards immunoassays?

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Joris R. Delanghe ◽  
Matthijs N. Oyaert ◽  
Veronique V. Stove
Keyword(s):  
Pancreatic Lipase

Do the Natural Chemical Compounds Interact with the Same Targets of Current Pharmacotherapy for Weight Management?-A Review

2019 ◽  
Vol 20 (4) ◽  
pp. 399-411 ◽  
Author(s):  
Shiqi Luo ◽  
George Binh Lenon ◽  
Harsharn Gill ◽  
Heidi Yuen ◽  
Angela Wei Hong Yang ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Management ◽  
Pancreatic Lipase ◽  
Weight Reduction ◽  
Chemical Compounds ◽  
Alpha Amylase ◽  
Melanocortin Receptor ◽  
Health Concern ◽  
European Medicines Agency ◽  
Ppar Γ

Background: Obesity has become a worldwide health concern. Pharmacotherapies are now being introduced because lifestyle modifications alone are insufficient for weight management. The treatment outcomes of current approved anti-obesity agents are not satisfying due to drug-related intolerances. And so natural therapies including herbal medicines are popular alternatives for weight reduction; however, there are limited studies about their mechanism of actions. Methods: Five databases (PubMed, Scopus, Google Scholar, Science Direct, Proquest) were searched to investigate the targets and safety profiles of the current and past anti-obesity drugs that have been approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA) as well as the commonly used off-label agents. The targets for weight-loss natural products and their principle bioactive components have also been searched. Only articles in English were included. Results: The targets for current anti-obesity single agents include pancreatic lipase, Glucagon Like Peptide-1(GLP-1) receptor, and serotonin 2C (5-HT2C) receptor. Potential targets such as amylin, pancreatic alpha amylase, leptin receptor, melanocortin receptor 4 receptor (MC4R), Peroxisome Proliferator- Activated Receptors gamma (PPAR γ), endocannabinoid 1 (CB1) receptor and Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) were discussed in various studies. Natural compounds have been found to interact with targets like pancreatic lipase, pancreatic alpha amylase, AMPK and PPAR γ to achieve weight reduction. Conclusion: Current pharmacotherapies and natural chemical compounds do act on same targets. Further investigations on the interactions between herbal compounds and the above targets are essential for the development of novel weight-loss therapies.

scholarly journals STUDIES ON PANCREATIC LIPASE

1938 ◽  
Vol 126 (1) ◽  
pp. 109-115
Author(s):  
L. Rabinowitch ◽  
A.M. Wynne
Keyword(s):  
Pancreatic Lipase
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