Genotyping and phenotyping of CYP2D6 and CYP3A isoenzymes in patients with alcohol use disorder: correlation with haloperidol plasma concentration

2017 ◽  
Vol 32 (3) ◽  
Author(s):  
Dmitry A. Sychev ◽  
Mikhail S. Zastrozhin ◽  
Igor I. Miroshnichenko ◽  
Natalia V. Baymeeva ◽  
Valery V. Smirnov ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Equilibrium Concentration ◽  
Primary Objective ◽  
Plasma Drug ◽  
Metabolism Rate ◽  
Genes Encoding ◽  
Allele Specific ◽  
Male Patients ◽  
Contradictory Data

AbstractBackground:Haloperidol is used for the treatment of alcohol use disorders in patients with signs of alcohol-related psychosis. Haloperidol therapy poses a high risk of adverse drug reactions (ADR). Contradictory data, which include the effects of genetic polymorphisms in genes encoding the elements of haloperidol biotransformation system on haloperidol metabolism rate and plasma drug concentration ratio, are described in patients with different genotypes. The primary objective of this study was to investigate the effects ofMethods:The study included 69 male patients with alcohol use disorder. Genotyping was performed using the allele-specific real-time PCR.Results:Results indicated that both C/D indexes and equilibrium concentration levels depend onConclusions:The study demonstrates that

scholarly journals Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chun Il Park ◽  
Hae Won Kim ◽  
Syung Shick Hwang ◽  
Jee In Kang ◽  
Se Joo Kim
Keyword(s):  
Dna Methylation ◽  
Alcohol Use ◽  
Childhood Trauma ◽  
Stress Responses ◽  
Alcohol Use Disorder ◽  
Risk Allele ◽  
Linear Regression Analysis ◽  
Allele Specific ◽  
Male Patients ◽  
Trait Resilience

AbstractThe FKBP5 gene is known to have an important role in alcohol use disorder (AUD) in response to stress and has been reported to affect stress responses by interacting with childhood trauma. This study investigated the effects of the FKBP5 polymorphism rs1360780 and childhood trauma on trait resilience in male patients with AUD. In addition, allele-specific associations between FKBP5 DNA methylation and resilience were examined. In total, 297 men with AUD were assessed for alcohol use severity, childhood trauma, resilience, and impulsivity. Genotyping for FKBP5 rs1360780 and DNA methylation were analyzed. The effects of the rs1360780 single nucleotide polymorphism (SNP) and clinical variables on resilience were tested using linear regression analysis. Possible associations between FKBP5 DNA methylation and resilience were tested with partial correlation analysis. The rs1360780 risk allele, a low education level, and high impulsivity were associated with diminished resilience, whereas no significant main or interaction effect of childhood trauma with the SNP rs1360780 genotype on resilience was shown. No significant association between FKBP5 DNA methylation and resilience was found. The present study demonstrated the involvement of the rs1360780 risk allele in trait resilience in men with AUD, suggesting that the genetic vulnerability of FKBP5 may influence resilience related to AUD.

scholarly journals Surface-Based Parameters of Brain Imaging in Male Patients with Alcohol Use Disorder

2016 ◽  
Vol 13 (5) ◽  
pp. 511
Author(s):  
Sungjin Im ◽  
Sang-Gu Lee ◽  
Jeonghwan Lee ◽  
Siekyeong Kim ◽  
Chul-Jin Shin ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Brain Imaging ◽  
Alcohol Use Disorder ◽  
Male Patients

scholarly journals Knowledge of Prevention Measures and Information About Coronavirus in Romanian Male Patients with Severe Mental Illness and Severe Alcohol Use Disorder

2020 ◽  
Vol Volume 16 ◽  
pp. 2857-2864
Author(s):  
Valentin Matei ◽  
Alexandru Pavel ◽  
Ana Giurgiuca ◽  
Alina Roșca ◽  
Arina Sofia ◽  
...  
Keyword(s):  
Mental Illness ◽  
Alcohol Use ◽  
Severe Mental Illness ◽  
Alcohol Use Disorder ◽  
Prevention Measures ◽  
Male Patients

CYP3A subfamily activity affects the equilibrium concentration of Phenazepam® in patients with anxiety disorders and comorbid alcohol use disorder

2020 ◽  
Vol 21 (7) ◽  
pp. 449-457
Author(s):  
Mikhail Sergeevich Zastrozhin ◽  
Valentin Yurievich Skryabin ◽  
Alexander Sergeevich Sorokin ◽  
Aleksey Evgenievich Petukhov ◽  
Valery Valerievich Smirnov ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Anxiety Disorders ◽  
Alcohol Use Disorder ◽  
Equilibrium Concentration ◽  
Inverse Correlation ◽  
Cyp3a Activity ◽  
Dose Ratio ◽  
Significant Inverse Correlation ◽  
Safety And Efficacy ◽  
Cortisol Ratio

Phenazepam® is prescribed to relieve anxiety and sleep disorders during alcohol withdrawal, although it is associated with undesirable side effects. Aim: To demonstrate changes in the safety and efficacy profiles of Phenazepam in patients with anxiety disorders and comorbid alcohol use disorder. Materials & methods: A total of 94 Russian patients with alcohol use disorder received 4.0 mg of Phenazepam per day in tablets. We used a urinary 6-beta-hydroxycortisol/cortisol ratio to evaluate CYP3A activity. Results: A statistically significant inverse correlation between Phenazepam plasma concentration and CYP3A activity was found (r = -0.340 and p = 0.017). Correlation between the concentration/dose ratio and phenotyping results was also statistically significant (r = 0.301 and p = 0.026). Conclusion: The safety and efficacy of Phenazepam depend on CYP3A genetic polymorphisms.

Sign in / Sign up

Export Citation Format

Share Document