Digital Devices and Cognitive Functions in Children

The other contributors confirmed the absence of a reportable conflict of interests The influence of dynamically changing habits associated with the use of digital devices (DD) on the child’s brain is one of the most topical issues of the last decade. Ambiguous or contradictory data on this issue indicate the need of systematizing all the results of scientific research. This analysis shows negative effect of large amount of screen time on the development of children at early age, their academic performance, and attention at older ages due to media absenteeism, as well as the correlation between the use of digital devices with delayed reward. It is necessary to update and to conduct qualitative research to understand the issue in more comprehensive way.

Novel Perspectives on the Development of the Amygdala in Rodents

The amygdala is a hyperspecialized brain region composed of strongly inter- and intraconnected nuclei involved in emotional learning and behavior. The cellular heterogeneity of the amygdalar nuclei has complicated straightforward conclusions on their developmental origin, and even resulted in contradictory data. Recently, the concentric ring theory of the pallium and the radial histogenetic model of the pallial amygdala have cleared up several uncertainties that plagued previous models of amygdalar development. Here, we provide an extensive overview on the developmental origin of the nuclei of the amygdaloid complex. Starting from older gene expression data, transplantation and lineage tracing studies, we systematically summarize and reinterpret previous findings in light of the novel perspectives on amygdalar development. In addition, migratory routes that these cells take on their way to the amygdala are explored, and known transcription factors and guidance cues that seemingly drive these cells toward the amygdala are emphasized. We propose some future directions for research on amygdalar development and highlight that a better understanding of its development could prove critical for the treatment of several neurodevelopmental and neuropsychiatric disorders.

Membrane lipids and maximum lifespan in clownfish

The longevity-homeoviscous adaptation (LHA) theory of ageing states that lipid composition of cell membranes is linked to metabolic rate and lifespan, which has been widely shown in mammals and birds but not sufficiently in fish. In this study, two species of the genus Amphiprion (Amphiprion percula and Amphiprion clarkii, with estimated maximum lifespan potentials [MLSP] of 30 and 9–16 years, respectively) and the damselfish Chromis viridis (estimated MLSP of 1–2 years) were chosen to test the LHA theory of ageing in a potential model of exceptional longevity. Brain, livers and samples of skeletal muscle were collected for lipid analyses and integral part in the computation of membrane peroxidation indexes (PIn) from phospholipid (PL) fractions and PL fatty acid composition. When only the two Amphiprion species were compared, results pointed to the existence of a negative correlation between membrane PIn value and maximum lifespan, well in line with the predictions from the LHA theory of ageing. Nevertheless, contradictory data were obtained when the two Amphiprion species were compared to the shorter-lived C. viridis. These results along with those obtained in previous studies on fish denote that the magnitude (and sometimes the direction) of the differences observed in membrane lipid composition and peroxidation index with MLSP cannot explain alone the diversity in longevity found among fishes.

Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells

Insulin is secreted in a pulsatile pattern, with important physiological ramifications. In pancreatic β-cells, which are the cells that synthesize insulin, insulin exocytosis is elicited by pulses of elevated intracellular Ca2+ initiated by bursts of electrical activity. In parallel with these electrical and Ca2+ oscillations are oscillations in metabolism, and the periods of all of these oscillatory processes are similar. A key question that remains unresolved is whether the electrical oscillations are responsible for the metabolic oscillations via the effects of Ca2+, or whether the metabolic oscillations are responsible for the electrical oscillations due to the effects of ATP on ATP-sensitive ion channels? Mathematical modeling is a useful tool for addressing this and related questions as modeling can aid in the design of well-focused experiments that can test the predictions of particular models and subsequently be used to improve the models in an iterative fashion. In this article, we discuss a recent mathematical model, the Integrated Oscillator Model (IOM), that was the product of many years of development. We use the model to demonstrate that the relationship between calcium and metabolism in beta cells is symbiotic: in some contexts, the electrical oscillations drive the metabolic oscillations, while in other contexts it is the opposite. We provide new insights regarding these results and illustrate that what might at first appear to be contradictory data are actually compatible when viewed holistically with the IOM.

Neoproterozoic Deposits of the Bashkir Mega-Anticlinorium (Southern Urals): State of the Art in Regional Stratigraphy

—This paper presents an alternative variant of stratigraphic subdivision of the upper Riphean–Vendian deposits (approximately corresponding to the Neoproterozoic Erathem of the International Chronostratigraphic Chart (ICC)) of the Bashkir Mega-Anticlinorium (BMA), based on the modern concepts of changes in the biosphere, atmosphere, and hydrosphere (and, accordingly, in the climate and the course of sedimentary processes) in the period ~1000–540 Ma, with regard to the results of recent studies and the proposals for improving the Russian General Stratigraphic Scale (GSS) of the Precambrian. The strict necessity of subdividing chronostratigraphic and lithostratigraphic units is shown. The presented data give grounds to regard the Zil’merdak Formation as a Group and assign three of its lower formations to the Middle Riphean (Yurmatinian). It is shown that the period of accumulation of the Karatau Group (comprising the Katav, Inzer, Min’yar, and Uk formations) was significantly shorter than the duration of the Late Riphean (Karatavian). Special attention is focused on the age of the Uk Formation (analysis of the existing data made it possible to refine its stratigraphic position): It formed, most likely, in the period 780–740 Ma. A high uncertainty of the stratigraphic position of the overlying geologic bodies is demonstrated. The Bakeevo, Tolparovo, Suirovo, and Kurgashla formations must be regarded as part of the Terminal Riphean (Arshinian). The Arsha Group, comprising the Bainas, Makhmutovo, Igonino, and Shum formations in the Tirlyan trough and represented by the Krivaya Luka Formation in the Krivaya Luka syncline, should not be totally assigned to the Terminal Riphean. It is proposed to exclude the Bakeevo Formation and the Tolparovo–Suirovo sequence from the Asha Group, because these deposits are, most likely, a modification of the Arsha Group located on the western flank of the BMA. The Uryuk Formation is probably of pre-Vendian age. The current contradictory data on the stratigraphy of the supra-Uryuk unit of the Asha Group are interpreted. The ages of the geologic bodies composing the Group and its stratigraphic interval still call for a thorough study.

Characterization and classification of numerical data patterns using Annotated Paraconsistent Logic and the effect of contradiction

This work describes the development of a computational mathematical model that uses Annotated Paraconsistent Logic - APL and a concept derived from it, the effect of contradiction, to identify patterns in numerical data for pattern classification purposes. The APL admits paraconsistent and paracomplete logical principles, which allow the manipulation of inconsistent and contradictory data, and its use allowed the identification and quantization of the attribute related to the contradiction. To validate the model, series of Raman spectroscopies obtained after exposure of proteins, lipids and nucleic acids, collected from cutaneous tissue cell samples previously examined for the detection of cancerous lesions, identified as basal carcinoma, melanoma and normal, were used. Initially, the attributes related to contradiction, derivative and median obtained from spectroscopies were identified and quantified. A machine learning process with approximately 31.6% of each type of samples detects a sequence of spectroscopies capable of characterizing and classifying the type of lesion through the chosen attributes. Approximately 68.4% of the samples are used for classification tests. The proposed model identified a segment of spectroscopies where the classification of test samples had a hit rate of 76.92%. As a differential and innovation of this work, the use of APL principles in a complete process of training, learning and classification of patterns for numerical data sets stands out, with flexibility to choose the attributes used for the characterization of patterns, and a quantity of samples of about one third of the total required for characterization.

COVID-19 Therapy: the Role of Antirheumatic Drugs

Currently, the close attention of the medical and international community is still riveted on the novel coronavirus infection, which caused the pandemic in 2020. Understanding the underlying mechanisms of coronavirus disease-2019 (COVID-19) made it possible to move from the empirical selection of therapy, which was observed at the beginning of the pandemic, to the pathogenetically justified prescription of drugs, including glucocorticoids, anticoagulants, as well as some antirheumatic drugs. However, despite the huge amount of scientific and clinical material accumulated over 1.5 years, the interest in this problem does not wane both due to the existence of a number of unresolved issues, and due to the constant emergence of new (often contradictory) data.

Successful percutaneous stenting of coarctation of the aorta in Turner syndrome – a case report and literature review

Turner syndrome (TS) is the most common chromosomal abnormality affecting females and cardiac abnormalities have been described in up to 50% of patients. Although coarctation represents one of the most frequent cardiac malformation, treatment options in these patients represent an area of debate, due to associated aortopathy and risk for aortic dissection. In addition to the contradictory data found in the literature, regarding the safety profile and utility of stenting of coarctation of the aorta in TS patients, we present the case of a patient of pediatric age, who successfully underwent the procedure, being free from periprocedural and short-term complications. Beside the presentation itself, we aimed to review and summarize the data available in the literature regarding this topic. As a conclusion, we emphasize the role of minimally invasive interventional therapy and wish to underline the need of further, larger scale studies and guidelines in this patient group. Given the related aortopathy, all preventive measures should be undertaken to avoid aortic dissection during stent implantation in this vulnerable population. Although the evolution of our patient was favorable, data found in the literature is somewhat contradictory and a close follow-up is indicated to help evaluate the risk of long-term complications.

Unusual Word Problems and the Development of Critical Thinking in Early School Students

Nowadays, it is increasingly difficult for people to make their way in a rapidly changing world. Critical thinkers are able to function well in such a changing environment and their education should begin in early childhood. This paper presents the results of an experimental study on the development of critical thinking of third grade elementary school students. Unusual word problems with missing or contradictory data, an ambiguous solution, or with unrealistic content (meaningless in real life) served as a tool for developing this type of thinking. These problems provoked the students to think, to critically analyze both the content and data of word problems. This, in turn, helped the students become more reflective, notice missing or contradictory data, ambiguity of a solution or lack of realism, fill in missing data, correct contradictory information and make unrealistic data realistic, as well as seek all possibilities for a solution. Thus, their critical thinking skills developed.

Serum secreted frizzled-related protein 5 in relation to insulin sensitivity and its regulation by insulin and free fatty acids

Purpose Secreted frizzled-related protein 5 (SFRP5) is an adipokine, which acts as an inhibitor of noncanonical WNT signaling pathway. It has been suggested to exert anti-inflammatory and insulin-sensitizing effects, however, contradictory data has also been reported. The aim of this study was to assess serum SFRP5 concentration in a young healthy population in relation to insulin sensitivity and its regulation by hyperinsulinemia and/or serum free fatty acids (FFA) elevation. Methods We examined 150 healthy subjects (83 normal-weight and 67 overweight/obese). Insulin sensitivity (M) was measured with hyperinsulinemic-euglycemic clamp. In 20 male subjects, clamp was prolonged to 6 h and after 1 week another clamp with the concurrent Intralipid/heparin infusion was performed. Independent group of 10 male subjects received infusions of Intralipid/heparin or saline in 1-week interval. Results Baseline SFRP5 was lower in the overweight/obese group (p = 0.01) and was positively associated with M (r = 0.23, p = 0.006) and serum adiponectin (r = 0.55, p < 0.001) and negatively with BMI (r = −0.18, p = 0.03). In multiple regression analysis, adiponectin was independently associated with SFRP5. Insulin infusion resulted in a decrease in serum SFRP5, both at 120′ (p = 0.02) and 360′ (p = 0.031). This effect was not observed during the clamp with Intralipid/heparin as well as during Intralipid/heparin alone or saline infusions. Conclusions The relation between SFRP5 and insulin sensitivity is mainly dependent on adiponectin. FFA abolish a decrease in circulating SFRP5 caused by insulin, but Intralipid/heparin infusion alone does not regulate SFRP5 concentration. Insulin seems to be more important factor in the regulation of circulating SFRP5 levels than FFA.