A case of statin-induced liver injury with positive rechallenge with a second statin. Is there a class effect?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Giovanna Onfiani ◽  
Fabio Nascimbeni ◽  
Francesca Carubbi
Keyword(s):  
Liver Injury ◽  
Clinical Symptoms ◽  
High Risk Population ◽  
Drug Induced ◽  
Case Presentation ◽  
Drug Induced Liver Injury ◽  
Aged Woman ◽  
Cardiovascular Morbidity And Mortality ◽  
Middle Aged Woman

Abstract Objectives Statins have proved to reduce cardiovascular morbidity and mortality in high-risk population and are generally well tolerated, although adverse events can occur. Up to 3% of patients develop aminotransferases elevation, which usually normalizes with continued treatment and hardly is associated with clinical symptoms. Serious statin-related liver injury is exceedingly rare. Furthermore, literature regarding rechallenge with a second statin is extremely poor. Some authors caution that re-exposure to these drugs is associated with a more serious liver injury but safe switching to a second statin after drug-induced liver injury (DILI) is also reported. Case presentation We describe a case of a middle-aged woman who developed hepatocellular liver injury after simvastatin dose escalation; a rechallenge with low dose rosuvastatin caused rapid recurrence of DILI. Conclusions In our opinion, clinicians should be very cautious upon rechallenge and closely follow-up patients who experienced statin-induced liver injury when trying re-exposure to another statin.

scholarly journals Long-term follow-up of patients with mild to moderate drug-induced liver injury

2007 ◽  
Vol 26 (1) ◽  
pp. 79-85 ◽  
Author(s):  
E. BJÖRNSSON ◽  
E. KALAITZAKIS ◽  
V. AV KLINTEBERG ◽  
N. ALEM ◽  
R. OLSSON
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Long Term Follow Up

scholarly journals Tuberculosis Arthritis Genu Sinistra with Drug-Induced Liver Injury, COVID 19 Confirmed

2022 ◽  
Vol 6 (3) ◽  
pp. 1460-1464
Author(s):  
Yonis Ismed ◽  
Radiyati Umi Partan ◽  
Ismail Bastomi
Keyword(s):  
Liver Injury ◽  
Extrapulmonary Tuberculosis ◽  
Left Knee ◽  
Drug Induced ◽  
Case Presentation ◽  
Drug Induced Liver Injury ◽  
Main Complaint ◽  
Laboratory Examinations ◽  
Hepatocyte Death ◽  
Significant Health

Background. Tuberculosis is still a significant health problem, especially in developing countries. Although pulmonary tuberculosis is the most common form of the disease, extrapulmonary tuberculosis also contributes significantly to morbidity and mortality. 10-15% of extrapulmonary cases are due to tuberculous arthritis. The following is a case report of a 36-year-old woman with a diagnosis of genu Sinistra tuberculosis arthritis and drug-induced hepatotoxic injury due to OAT. Case presentation. A woman, 36 years old, Muslim, addresses Banyuasin. The patient is a housewife, treated at Dr. Moh Hoesin General Hospital since October 11, 2021. The main complaint in the form of pain in the left knee has been getting worse since 1 week before being admitted to the hospital. 4 months before admission the hospital, the patient complained of left knee pain, the pain felt like being stabbed, coming and going, especially when walking. In this patient, there was a complaint of nausea that was felt in the pit of the stomach. The results of laboratory examinations showed an increase in the transaminase enzyme and hyperuricemia, so it was suspected that the patient had DILI due to OAT drugs. Hepatocyte death in DILI can occur through two processes, namely processes mediated by apoptosis or necrosis. In apoptosis, cell shrinkage and fragmentation occur into small pieces with the cell membrane intact. These fragments are cleared by phagocytosis and generally do not stimulate the host immune response. Conclusion. A patient diagnosed with arthritis tuberculosis genu Sinistra with Drug-Induced Liver Injury and Confirmed COVID 19.

scholarly journals Pegvisomant-induced cholestatic hepatitis with jaundice in a patient with Gilbert's syndrome

2009 ◽  
Vol 160 (5) ◽  
pp. 869-872 ◽  
Author(s):  
Ignacio Bernabeu ◽  
Jose Cameselle-Teijeiro ◽  
Felipe F Casanueva ◽  
Monica Marazuela
Keyword(s):  
Liver Injury ◽  
Somatostatin Analogs ◽  
Liver Steatosis ◽  
Drug Induced ◽  
Gilbert’S Syndrome ◽  
Drug Induced Liver Injury ◽  
Gilbert's Syndrome ◽  
Frequent Monitoring ◽  
Long Acting

We report on a patient with active acromegaly and Gilbert's syndrome who developed severe hepatic dysfunction during pegvisomant (PEGv) monotherapy. She was partially resistant to all previous therapies, including long-acting somatostatin analogs and cabergoline. Five months after starting PEGv therapy, with an already normalized IGF1, she developed cholestatic liver dysfunction with jaundice. Liver or biliary diseases including biliary sludge, cholelithiasis or liver steatosis were excluded. A liver biopsy was in keeping with drug-induced liver injury. The discontinuation of PEGv was followed by full clinical and biochemical recovery in 6 weeks. PEGv therapy was not resumed. Apart from a minimal increase of bilirubin levels, no liver function test abnormalities were found during the 4-year follow-up period after the PEGv was discontinued. Drug-induced liver injury is the most serious systemic adverse event resulting from PEGv therapy. Since patients with mild and asymptomatic liver disease could be at a higher risk of PEGv-induced hepatotoxicity, frequent monitoring of hepatic enzymes should be required in these cases.

1138 IDIOSYNCRATIC DRUG-INDUCED LIVER INJURY (DILI): FOLLOW-UP IN A COHORT OF PATIENTS IDENTIFIED IN 24 TERTIARY CARE CENTRES IN SPAIN

2010 ◽  
Vol 52 ◽  
pp. S440
Author(s):  
Y. Borraz ◽  
M.C. Fernández ◽  
G. Peláez ◽  
M. Romero-Gómez ◽  
J.A. Durán ◽  
...  
Keyword(s):  
Liver Injury ◽  
Tertiary Care ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Case Report and Cohort Analysis of Drug-Induced Liver Injury Associated with Daptomycin

2014 ◽  
Vol 58 (8) ◽  
pp. 4902-4903 ◽  
Author(s):  
Nicole Bohm ◽  
Charles Makowski ◽  
Mario Machado ◽  
Adam Davie ◽  
Nelson Seabrook ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Injury ◽  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Single Center ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Retrospective Cohort Analysis ◽  
Creatinine Kinase Level

ABSTRACTA patient receiving daptomycin developed asymptomatic transaminitis and hyperbilirubinemia without concurrent multiorgan dysfunction or elevation of his creatinine kinase level. After ruling out other etiologies, the liver injury was attributed to daptomycin and was subsequently resolved. A single-center retrospective cohort analysis of baseline and follow-up liver function panels (n= 614) from all admissions from 2008 to 2013 during which daptomycin was administered did not reveal any other cases of probable or definite drug-induced liver injury associated with daptomycin.

scholarly journals Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry

Hepatology ◽  
2006 ◽  
Vol 44 (6) ◽  
pp. 1581-1588 ◽  
Author(s):  
Raúl J. Andrade ◽  
M. Isabel Lucena ◽  
Neil Kaplowitz ◽  
Beatriz García-Muņoz ◽  
Yolanda Borraz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Long Term Follow Up

scholarly journals Drug-Induced Liver Injury: A Unique Presentation of Single-Dose Administration of Propylthiouracil

2020 ◽  
Vol 8 ◽  
pp. 232470962095132
Author(s):  
Simcha Weissman ◽  
Nishan G. Rajaratnam ◽  
Nabeel Qureshi ◽  
Faisal Inayat ◽  
Sameh Elias
Keyword(s):  
Single Dose ◽  
Liver Injury ◽  
Liver Enzymes ◽  
Antithyroid Drug ◽  
Thyroid Storm ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Elevated Liver Enzymes ◽  
Pharmacologic Agents

Antithyroid drug-induced severe liver injury is an uncommon but serious complication. We hereby delineate the case of a 38-year-old female who presented to the emergency department for an impending thyroid storm. After initiation of a single dose of propylthiouracil, her liver enzymes went into the thousands. She was subsequently admitted to the intensive care unit. Propylthiouracil was discontinued and corticosteroids were initiated with the resolution of her elevated liver enzymes. On follow-up, her liver function was at its baseline and thyroid hormone levels were under control. We hope this report will encourage clinicians to cast a broad differential diagnosis in patients presenting with liver injury in the acute setting. Furthermore, it is imperative to raise awareness regarding the ever-increasing list of pharmacologic agents that can perpetuate drug-induced hepatotoxicity.

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